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The 5-fraction regimen is preferred when feasible. After completing dose-escalated RT, patients who received less than 6 months of chemotherapy at study entry are encouraged to receive the remaining chemotherapy to total 6 months of chemotherapy. Patients may continue chemotherapy treatment beyond 6 months at physician's discretion. Additionally, patients undergo blood sample collection, CT, MRI and tumor tissue biopsy throughout the study. Patients may optionally undergo PET\u002FCT prior to treatment.",[13,14,15,16,34,17,22,26,27],"Radiation: Dose-escalated Radiation Therapy",[36,45,53,61,78,85,110,118,136,156,203,223,242,248,273,285,290],{"type":37,"name":38,"description":39,"armGroupLabels":40,"otherNames":41},"PROCEDURE","Biopsy Procedure","Undergo tumor tissue biopsy",[9,30],[42,43,44],"Biopsy","BIOPSY_TYPE","Bx",{"type":37,"name":46,"description":47,"armGroupLabels":48,"otherNames":49},"Biospecimen Collection","Undergo blood sample collection",[9,30],[50,51,52],"Biological Sample Collection","Biospecimen Collected","Specimen Collection",{"type":54,"name":55,"description":56,"armGroupLabels":57,"otherNames":58},"DRUG","Capecitabine","Given capecitabine",[9,30],[59,60],"Ro 09-1978\u002F000","Xeloda",{"type":37,"name":62,"description":63,"armGroupLabels":64,"otherNames":65},"Computed Tomography","Undergo CT or PET\u002FCT",[9,30],[66,67,68,69,70,71,72,73,74,75,76,77],"CAT","CAT Scan","Computed Axial 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Pentahydrate","Folinoral","Folinvit","Foliplus","Folix","Imo","Lederfolat","Lederfolin","Leucosar","leucovorin","Rescufolin","Rescuvolin","Tonofolin","Wellcovorin",{"type":37,"name":204,"description":205,"armGroupLabels":206,"otherNames":207},"Magnetic Resonance Imaging","Undergo MRI",[9,30],[208,209,210,211,212,213,214,215,216,217,218,219,220,221,222],"Magnetic Resonance","Magnetic Resonance Imaging (MRI)","Magnetic resonance imaging (procedure)","Magnetic Resonance Imaging Scan","Medical Imaging, Magnetic Resonance \u002F Nuclear Magnetic Resonance","MR","MR Imaging","MRI","MRI Scan","MRIs","NMR Imaging","NMRI","Nuclear Magnetic Resonance Imaging","sMRI","Structural MRI",{"type":54,"name":224,"description":225,"armGroupLabels":226,"otherNames":227},"Nab-paclitaxel","Given nab-paclitaxel",[9],[228,229,230,231,232,233,234,235,236,237,238,239,240,241],"ABI 007","ABI-007","ABI007","Abraxane","Albumin-bound Paclitaxel","Albumin-Stabilized Nanoparticle Paclitaxel","Nanoparticle Albumin-bound Paclitaxel","Nanoparticle Paclitaxel","Naveruclif","Paclitaxel Albumin","paclitaxel albumin-stabilized nanoparticle formulation","Paclitaxel Nanoparticle Albumin-bound","Paclitaxel Protein-Bound","Protein-bound Paclitaxel",{"type":6,"name":243,"description":244,"armGroupLabels":245,"otherNames":246},"Observation Activity","Undergo observation",[9],[247],"Observation",{"type":54,"name":249,"description":250,"armGroupLabels":251,"otherNames":252},"Oxaliplatin","Given oxaliplatin",[9],[253,254,255,256,257,258,259,260,261,262,263,264,265,266,267,268,269,270,271,272],"1-OHP","Ai Heng","Aiheng","Dacotin","Dacplat","Diaminocyclohexane Oxalatoplatinum","Eloxatin","Eloxatine","Elplat","JM 83","JM-83","JM83","Oxalatoplatin","Oxalatoplatinum","RP 54780","RP-54780","RP54780","SR 96669","SR-96669","SR96669",{"type":37,"name":274,"description":275,"armGroupLabels":276,"otherNames":277},"Positron Emission Tomography","Undergo PET\u002FCT",[9,30],[278,279,280,281,282,283,284],"Medical 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MD Anderson Cancer Center","RECRUITING","Gilbert","Arizona","85234","United States","US",{"type":321,"coordinates":322},"Point",[323,324],-111.78903,33.35283,{"lat":324,"lon":323},[327,331],{"name":328,"role":329,"phone":330,"phoneExt":289,"email":289},"Site Public Contact","CONTACT","602-747-9738",{"name":332,"role":310,"phone":289,"phoneExt":289,"email":289},"Gary V. Walker",{"facility":334,"status":314,"city":315,"state":316,"zip":335,"country":318,"countryCode":319,"cosmosGeoPoint":336,"geoPoint":338,"contacts":339},"Arizona Center for Cancer Care - Gilbert","85297",{"type":321,"coordinates":337},[323,324],{"lat":324,"lon":323},[340,343],{"name":328,"role":329,"phone":341,"phoneExt":289,"email":342},"480-278-8261","penny.labriola@arizonaccc.com",{"name":344,"role":310,"phone":289,"phoneExt":289,"email":289},"Steven E. Sckolnik",{"facility":346,"status":314,"city":347,"state":316,"zip":348,"country":318,"countryCode":319,"cosmosGeoPoint":349,"geoPoint":353,"contacts":354},"Arizona Center for Cancer Care-Peoria","Peoria","85381",{"type":321,"coordinates":350},[351,352],-112.23738,33.5806,{"lat":352,"lon":351},[355,357],{"name":328,"role":329,"phone":356,"phoneExt":289,"email":289},"623-773-2873",{"name":344,"role":310,"phone":289,"phoneExt":289,"email":289},{"facility":359,"status":314,"city":360,"state":316,"zip":361,"country":318,"countryCode":319,"cosmosGeoPoint":362,"geoPoint":366,"contacts":367},"Arizona Center for Cancer Care - Phoenix","Phoenix","85027",{"type":321,"coordinates":363},[364,365],-112.07404,33.44838,{"lat":365,"lon":364},[368,369],{"name":328,"role":329,"phone":341,"phoneExt":289,"email":342},{"name":344,"role":310,"phone":289,"phoneExt":289,"email":289},{"facility":371,"status":314,"city":372,"state":316,"zip":373,"country":318,"countryCode":319,"cosmosGeoPoint":374,"geoPoint":378,"contacts":379},"Arizona Center for Cancer Care - Scottsdale","Scottsdale","85258",{"type":321,"coordinates":375},[376,377],-111.89903,33.50921,{"lat":377,"lon":376},[380,381],{"name":328,"role":329,"phone":341,"phoneExt":289,"email":342},{"name":344,"role":310,"phone":289,"phoneExt":289,"email":289},{"facility":383,"status":314,"city":384,"state":316,"zip":385,"country":318,"countryCode":319,"cosmosGeoPoint":386,"geoPoint":390,"contacts":391},"Arizona Center for Cancer Care-Surprise","Surprise","85374",{"type":321,"coordinates":387},[388,389],-112.33322,33.63059,{"lat":389,"lon":388},[392,395],{"name":328,"role":329,"phone":393,"phoneExt":289,"email":394},"412-339-5294","Roster@nrgoncology.org",{"name":344,"role":310,"phone":289,"phoneExt":289,"email":289},{"facility":397,"status":314,"city":398,"state":316,"zip":399,"country":318,"countryCode":319,"cosmosGeoPoint":400,"geoPoint":404,"contacts":405},"Arizona Center for Cancer Care","Tempe","85284",{"type":321,"coordinates":401},[402,403],-111.90931,33.41477,{"lat":403,"lon":402},[406,407],{"name":328,"role":329,"phone":341,"phoneExt":289,"email":342},{"name":344,"role":310,"phone":289,"phoneExt":289,"email":289},{"facility":409,"status":314,"city":410,"state":411,"zip":412,"country":318,"countryCode":319,"cosmosGeoPoint":413,"geoPoint":417,"contacts":418},"NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro","Jonesboro","Arkansas","72401",{"type":321,"coordinates":414},[415,416],-90.70428,35.8423,{"lat":416,"lon":415},[419,422],{"name":328,"role":329,"phone":420,"phoneExt":289,"email":421},"870-936-7066","Emily.Carvell@bmhcc.org",{"name":423,"role":310,"phone":289,"phoneExt":289,"email":289},"Shelby Lane",{"facility":425,"status":314,"city":426,"state":427,"zip":428,"country":318,"countryCode":319,"cosmosGeoPoint":429,"geoPoint":433,"contacts":434},"Mission Hope Medical Oncology - Arroyo Grande","Arroyo Grande","California","93420",{"type":321,"coordinates":430},[431,432],-120.59073,35.11859,{"lat":432,"lon":431},[435,438],{"name":328,"role":329,"phone":436,"phoneExt":289,"email":437},"720-874-1881","ResearchInstituteInquiries@CommonSpirit.org",{"name":439,"role":310,"phone":289,"phoneExt":289,"email":289},"Shahzad Siddique",{"facility":441,"status":314,"city":442,"state":427,"zip":443,"country":318,"countryCode":319,"cosmosGeoPoint":444,"geoPoint":448,"contacts":449},"AIS Cancer Center at San Joaquin Community Hospital","Bakersfield","93301",{"type":321,"coordinates":445},[446,447],-119.01871,35.37329,{"lat":447,"lon":446},[450,452],{"name":328,"role":329,"phone":451,"phoneExt":289,"email":289},"661-323-4673",{"name":453,"role":310,"phone":289,"phoneExt":289,"email":289},"Luis Mariscal",{"facility":455,"status":314,"city":456,"state":427,"zip":457,"country":318,"countryCode":319,"cosmosGeoPoint":458,"geoPoint":462,"contacts":463},"Alta Bates Summit Medical Center-Herrick Campus","Berkeley","94704",{"type":321,"coordinates":459},[460,461],-122.27275,37.87159,{"lat":461,"lon":460},[464,466],{"name":328,"role":329,"phone":289,"phoneExt":289,"email":465},"clinicalresearch@sutterhealth.org",{"name":467,"role":310,"phone":289,"phoneExt":289,"email":289},"Christopher U. 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Weston","Weston","54476",{"type":321,"coordinates":4216},[4217,4218],-89.54762,44.8908,{"lat":4218,"lon":4217},[4221,4222],{"name":328,"role":329,"phone":3918,"phoneExt":289,"email":3919},{"name":3921,"role":310,"phone":289,"phoneExt":289,"email":289},{"facility":4224,"status":314,"city":4225,"state":3880,"zip":4226,"country":318,"countryCode":319,"cosmosGeoPoint":4227,"geoPoint":4231,"contacts":4232},"Aspirus Cancer Care - Wisconsin Rapids","Wisconsin Rapids","54494",{"type":321,"coordinates":4228},[4229,4230],-89.81735,44.38358,{"lat":4230,"lon":4229},[4233,4235],{"name":328,"role":329,"phone":4234,"phoneExt":289,"email":289},"715-422-7718",{"name":3892,"role":310,"phone":289,"phoneExt":289,"email":289},{"facility":4237,"status":314,"city":4238,"state":4239,"zip":4240,"country":4241,"countryCode":4242,"cosmosGeoPoint":4243,"geoPoint":4247,"contacts":4248},"Cross Cancer Institute","Edmonton","Alberta","T6G 1Z2","Canada","CA",{"type":321,"coordinates":4244},[4245,4246],-113.46871,53.55014,{"lat":4246,"lon":4245},[4249,4251],{"name":328,"role":329,"phone":4250,"phoneExt":289,"email":289},"780-432-8500",{"name":4252,"role":310,"phone":289,"phoneExt":289,"email":289},"Kurian Joseph",{"type":4254,"investigatorFullName":289,"investigatorTitle":289,"investigatorAffiliation":289,"oldNameTitle":289,"oldOrganization":289},"SPONSOR","100589739",false,"NCT06958328","Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer","A Phase III Randomized Trial of Dose Escalated Radiation in Locally Advanced Pancreas Cancer (LAPC) Patients (LAP100)","LAP100","Inclusion Criteria:\n\n* At time of enrollment, the patient must have received 4-6 months of active chemotherapy with FOLFIRINOX or NALIRIFOX or gemcitabine\u002Fnab-paclitaxel. Patients are permitted to receive more than 1 type of chemotherapy for toxicity reasons, but not for disease progression. \"Active chemotherapy\" refers to time on chemotherapy not counting treatment breaks (i.e. if a patient had 1 month of chemotherapy followed by 1 month break, this would count as 1 month chemotherapy). Study registration must occur within 45 days of last day of chemotherapy cycle\n* BASELINE PRE-ENTRY CHEMOTHERAPY REQUIREMENTS:\n* Pathologically (histologically or cytologically) proven diagnosis of pancreatic ductal adenocarcinoma\n* Locally advanced unresectable disease (as defined per the National Comprehensive Cancer Network \\[NCCN\\] guidelines and institutional tumor board review)\n* Patients must have baseline pre-chemotherapy scans for staging. Options include: CT chest\u002Fabdomen\u002Fpelvis, CT chest\u002FMRI abdomen\u002Fpelvis, CT chest\u002FCT pelvis\u002FMRI abdomen, or PET\u002FCT performed prior to enrollment\n* Age ≥ 18 years\n* Performance status Eastern Cooperative Oncology Group (ECOG) 0-2\n* Required initial laboratory values:\n\nAll laboratory values must be obtained any time prior to initiation of chemotherapy up to 30 days post initiation of chemotherapy\n\n* Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 3 x upper limit of normal (ULN)\n* BASELINE CA19-9 AND BILIRUBIN REQUIREMENTS: The purpose is to obtain a baseline CA19-9 in the setting of a normal (or close to normal) bilirubin, since serologic response by serial CA19-9 measurements is part of post-chemotherapy eligibility criteria\n\n  * If baseline CA19-9 \\> 37 U\u002FmL the concurrent bilirubin must be ≤ 1.5 x ULN. (Note: if the bilirubin is not ≤ 1.5 x ULN both the CA19-9 and concurrent bilirubin can be repeated until bilirubin is ≤ 1.5 x ULN, as long as done within specified timeframe \\[up to 30 days post chemotherapy initiation\\])\n  * If baseline CA19-9 U\u002FmL ≤ 37, there are no restrictions on the required concurrent bilirubin level, and this can be the accepted baseline value\n\n    * Prior radiation treatment\n* Has the patient had prior radiotherapy to the region of the study cancer that would result in overlap of radiation therapy fields\n* Prior non-overlapping radiation (e.g., breast, head and neck, extremity) is permitted\n* If uncertain about prior overlap, please contact the study principal investigator, Dr. Nina Sanford\n\n  * POST PRE-ENTRY CHEMOTHERAPY REQUIREMENTS:\n  * If baseline CA19-9 is elevated (defined as \\> 37 u\u002FmL) the post-pre-entry chemotherapy CA19-9 must be less than 37 u\u002FmL or a 50% decline from pre-chemotherapy level with absolute value less than 100u\u002FmL\n  * If baseline CA19-9 is not elevated (defined as ≤ 37 u\u002FmL) the post-pre-entry chemotherapy CA19-9 must remain ≤ 37 u\u002FmL\n  * No active duodenal or gastric ulcers\n  * No direct tumor invasion of the bowel or stomach\n  * Restaging scans showing at least stable disease (no progression). Options for scans include: CT chest\u002Fabdomen\u002Fpelvis, CT chest\u002FMRI abdomen\u002Fpelvis, or CT chest\u002FCT pelvis\u002FMRI abdomen, or PET\u002FCT performed prior to enrollment, with restaging CT showing at least stable disease\n  * Not pregnant and not nursing\n  * No cardiac condition that was the primary reason for hospitalization in the last 6 months\n  * New York Heart Association Functional Classification II or better (NYHA Functional Classification III\u002FIV are not eligible) (Note: Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification.)\n  * HIV-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial","ALL","18 Years",{"count":4265,"type":4266},356,"ESTIMATED","INTERVENTIONAL",[4269],"PHASE3","This phase III trial compares the effect of dose-escalated radiation therapy to usual care in patients with locally advanced unresectable pancreatic ductal adenocarcinoma who have received an initial 4-6 months of chemotherapy. Usual care options include additional chemotherapy, observation, or standard lower-dose radiation therapy. These treatments may delay tumor growth but have not been shown to improve survival. Radiation therapy uses high energy X-rays to kill cancer cells and shrink tumors. Dose-escalated radiation therapy involves the precise delivery of higher doses to the tumor, often over a shorter period of time. This trial assesses whether using dose-escalated radiation therapy can prolong survival.",[4272,4273,4274,4275],"Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma","Stage II Pancreatic Cancer AJCC v8","Stage III Pancreatic Cancer AJCC v8","Stage IV Pancreatic Cancer AJCC v8","2026-06-22",{"date":4278,"type":4279},"2026-06-25","ACTUAL",{"date":4281,"type":4279},"2025-08-21",{"date":4283,"type":4266},"2030-10-21",{"name":5,"class":6},322]