Two Versus One Week Breast Radiotherapy (RT)
ConditionBreast Cancer
Trial statusRecruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexFemale
AgeNot listed
SponsorWeill Medical College of Cornell University
About this trial
This study is comparing two different radiation therapy approaches for early breast cancer to see which one is better for patients. One group will receive radiation over one week (based on the FAST-FORWARD trial), and the other group will receive radiation over two weeks with an extra focused dose (called a "concomitant boost"). The study will look at how the treatments affect side effects, breast appearance, and cancer control in the breast. It also aims to find out if the two-week treatment does a better job at preventing cancer from coming back in the breast over the long term.
Eligibility criteria
Qualifiers
Women status post segmental mastectomy.
If unilateral, pT1-2 breast cancer excised with negative margins.
If bilateral, pT1-2 breast cancer excised with negative margins AND/OR pTis excised with negative margins.
Clinically N0 (cN0 as determined by ultrasound/SOUND criteria) or pN0-1 or Nx or sentinel node negative.
Disqualifiers
Previous radiation therapy to the ipsilateral breast.
>90 days from last surgery, unless s/p adjuvant chemotherapy.
>60 days from last chemotherapy.
Male breast cancer.
Trial design
Treatments tested in this trial
- Radiation therapy - 1 week
- Radiation therapy - 2 weeks
Treatment groups
400 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov