[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100625591":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":38,"locations":45,"responsibleParty":61,"collaborators":43,"id":64,"slug":43,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":43,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":43,"enrollmentInfo":72,"targetDuration":43,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":84,"whyStopped":43,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Mayo Clinic","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Tris-hydroxymethyl aminomethane (THAM)","EXPERIMENTAL","Patients randomized to the THAM arm will be treated with tris-hydroxymethyl aminomethane.\n\nDosage: Base excess less than -5, administer 500 mL of THAM",[13],"Drug: Tris-hydroxymethyl Aminomethane",{"label":15,"type":16,"description":17,"interventionNames":18},"Sodium bicarbonate (Bicarb)","ACTIVE_COMPARATOR","Patients randomized to the Bicarb arm will be treated with sodium bicarbonate (Bicarb).\n\nDosage: Base excess less than -5, administer 100 mEq of sodium bicarbonate",[19],"Drug: Sodium bicarbonate",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Sodium bicarbonate","Patients in the ICU following cardiothoracic surgery with use of cardiopulmonary bypass and requiring treatment for metabolic acidosis (base excess less than -5), will receive sodium bicarbonate (Bicarb) if randomized to the Bicarb arm.",[15],[27],"Bicarb",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Tris-hydroxymethyl Aminomethane","Patients in the ICU following cardiothoracic surgery with use of cardiopulmonary bypass, requiring treatment for metabolic acidosis (base excess less than -5), will receive tris-hydroxymethyl aminomethane (THAM) if randomized to the THAM arm.",[9],[33],"THAM",[35],{"name":36,"affiliation":5,"role":37},"Misty A. Radosevich, MD","PRINCIPAL_INVESTIGATOR",[39],{"name":40,"role":41,"phone":42,"phoneExt":43,"email":44},"Nicole M. Lenort, RRT, LRT","CONTACT","866-265-9263",null,"Lenort.Nicole@mayo.edu",[46],{"facility":5,"status":43,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Rochester","Minnesota","55901","United States","US",{"type":53,"coordinates":54},"Point",[55,56],-92.4699,44.02163,{"lat":56,"lon":55},[59,60],{"name":40,"role":41,"phone":42,"phoneExt":43,"email":43},{"name":36,"role":37,"phone":43,"phoneExt":43,"email":43},{"type":37,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":43,"oldOrganization":43},"Misty Radosevich","Principal Investigator","100625591",false,"NCT07424625","A Study of Tris-Hydroxymethyl Aminomethane (THAM) Versus Sodium Bicarbonate in Cardiac Surgical Patients","THAM VErsus Sodium BiCarbOnate In CaRdiac SuRgical PatiEnts, A PragmatiC, Comparative-effectiveness Prospective Trial","* Inclusion criteria\n\n  * Cardiothoracic surgery with use of cardiopulmonary bypass\n  * Presence of metabolic acidosis (defined as a base excess of \\\u003C-5)\n  * Minnesota Research Authorization\n* Exclusion criteria\n\n  * Non-cardiac surgery patients or cardiac surgery without cardiopulmonary bypass\n  * Absence of metabolic acidosis (metabolic acidosis being defined as a base excess of \\\u003C-5)\n  * Pregnant patients\n  * Prisoners\n  * Opt out of Minnesota Research Authorization","ALL","21 Years",{"count":73,"type":74},250,"ESTIMATED","INTERVENTIONAL",[77],"PHASE4","The purpose of this research is to determine if two commonly used medications to treat metabolic acidosis in the setting of cardiac surgery, sodium bicarbonate and THAM, are equivalent.",[80],"Metabolic Acidosis",[33,23,82,83],"metabolic acidosis","cardiac surgery","NOT_YET_RECRUITING","2026-06-11",{"date":87,"type":88},"2026-06-15","ACTUAL",{"date":90,"type":74},"2026-07",{"date":92,"type":74},"2027-08",{"name":5,"class":6},1]