[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100608344":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":40,"centralContacts":44,"locations":53,"responsibleParty":295,"collaborators":30,"id":298,"slug":30,"hasResults":299,"nctId":300,"briefTitle":301,"officialTitle":302,"acronym":30,"eligibilityCriteria":303,"healthyVolunteers":299,"sex":304,"minAge":305,"maxAge":306,"enrollmentInfo":307,"targetDuration":30,"studyType":310,"phases":311,"briefSummary":313,"conditions":314,"keywords":316,"overallStatus":323,"whyStopped":30,"lastUpdateSubmitDate":324,"lastUpdatePostDateStruct":325,"startDateStruct":328,"completionDateStruct":330,"leadSponsor":332,"locationsCount":333},{"fullName":5,"class":6},"Eye & ENT Hospital of Fudan University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Anti-IL-5 Monotherapy","EXPERIMENTAL","Mepolizumab 100mg subcutaneously every 4 weeks for 24 weeks",[13],"Drug: Mepolizumab",{"label":15,"type":10,"description":16,"interventionNames":17},"Anti-IL-5 + Simple Polypectomy","Combined therapy: A 100 mg dose of mepolizumab is initiated subcutaneously 2 weeks after simple polypectomy. Mepolizumab will be administered subcutaneously every 4 weeks for 24 weeks.",[13,18],"Procedure: Simple Polypectomy",{"label":20,"type":10,"description":21,"interventionNames":22},"Anti-IL-5 + Extended Endoscopic Sinus Surgery","Combined therapy: A 100 mg dose of mepolizumab is initiated subcutaneously 2 weeks after Extended Endoscopic Sinus Surgery. Mepolizumab will be administered subcutaneously every 4 weeks for 24 weeks.",[13,23],"Procedure: Extended Endoscopic Sinus Surgery",[25,31,36],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DRUG","Mepolizumab","Subcutaneous injection of mepolizumab is administered every 4 weeks for a total treatment duration of 24 weeks.",[20,15,9],null,{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":30},"PROCEDURE","Simple Polypectomy","Removal of nasal polyps in the middle meatus and superior turbinate region via the middle meatus and olfactory cleft, without opening the involved sinuses and without resection of diseased bone.",[15],{"type":32,"name":37,"description":38,"armGroupLabels":39,"otherNames":30},"Extended Endoscopic Sinus Surgery","1. Complete opening of all sinuses\n2. Resection of diseased mucosa and hyperplastic bone\n3. Ethmoid skeletonization with middle turbinectomy\n4. Draf IIb\u002FIII frontal dissection when indicated by CT severity.",[20],[41],{"name":42,"affiliation":5,"role":43},"Huabin Li, PhD","PRINCIPAL_INVESTIGATOR",[45,49],{"name":42,"role":46,"phone":47,"phoneExt":30,"email":48},"CONTACT","86-18816993402","allergyli@163.com",{"name":50,"role":46,"phone":51,"phoneExt":30,"email":52},"Hongfei Lou, PhD","86-15210295496","allerylhf@163.com",[54,72,87,102,116,131,142,157,172,187,202,217,228,239,250,265,280],{"facility":55,"status":30,"city":56,"state":57,"zip":58,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":67},"The First Affiliated Hospital of Chongqing Medical University","Chongqing","Chongqing Municipality","400016","China","CN",{"type":62,"coordinates":63},"Point",[64,65],106.55771,29.56026,{"lat":65,"lon":64},[68],{"name":69,"role":46,"phone":70,"phoneExt":30,"email":71},"Yucheng Yang, MD","86-13452018123","yychxh@163.com",{"facility":73,"status":30,"city":74,"state":75,"zip":76,"country":59,"countryCode":60,"cosmosGeoPoint":77,"geoPoint":81,"contacts":82},"The First Affiliated Hospital of Fujian Medical University","Fuzhou","Fujian","350005",{"type":62,"coordinates":78},[79,80],119.30611,26.06139,{"lat":80,"lon":79},[83],{"name":84,"role":46,"phone":85,"phoneExt":30,"email":86},"Qinghua Liu, MD","86-15280096007","15280096007@163.com",{"facility":88,"status":30,"city":89,"state":90,"zip":91,"country":59,"countryCode":60,"cosmosGeoPoint":92,"geoPoint":96,"contacts":97},"The Second Affiliated Hospital of Guangzhou Medical University","Guangzhou","Guangdong","510000",{"type":62,"coordinates":93},[94,95],113.25,23.11667,{"lat":95,"lon":94},[98],{"name":99,"role":46,"phone":100,"phoneExt":30,"email":101},"Fenghong Chen, MD","86-13560170816","chen_fenghong@163.com",{"facility":103,"status":30,"city":104,"state":90,"zip":105,"country":59,"countryCode":60,"cosmosGeoPoint":106,"geoPoint":110,"contacts":111},"Longgang District Central Hospital of Shenzhen","Shenzhen","518000",{"type":62,"coordinates":107},[108,109],114.0683,22.54554,{"lat":109,"lon":108},[112],{"name":113,"role":46,"phone":114,"phoneExt":30,"email":115},"Gui Yang, PhD","86-13510646616","303630898@qq.com",{"facility":117,"status":30,"city":118,"state":119,"zip":120,"country":59,"countryCode":60,"cosmosGeoPoint":121,"geoPoint":125,"contacts":126},"The First Affiliated Hospital of Harbin Medical University","Harbin","Heilongjiang","150001",{"type":62,"coordinates":122},[123,124],126.65,45.75,{"lat":124,"lon":123},[127],{"name":128,"role":46,"phone":129,"phoneExt":30,"email":130},"Tianhong Zhang, MD","86-13945073856","zth3856@126.com",{"facility":132,"status":30,"city":118,"state":119,"zip":133,"country":59,"countryCode":60,"cosmosGeoPoint":134,"geoPoint":136,"contacts":137},"The Second Hospital of Harbin Medical University","150086",{"type":62,"coordinates":135},[123,124],{"lat":124,"lon":123},[138],{"name":139,"role":46,"phone":140,"phoneExt":30,"email":141},"Yanan Sun, MD","86-13633631706","76202920@qq.com",{"facility":143,"status":30,"city":144,"state":145,"zip":146,"country":59,"countryCode":60,"cosmosGeoPoint":147,"geoPoint":151,"contacts":152},"The First Affiliated Hospital of Zhengzhou University","Zhengzhou","Henan","450052",{"type":62,"coordinates":148},[149,150],113.64861,34.75778,{"lat":150,"lon":149},[153],{"name":154,"role":46,"phone":155,"phoneExt":30,"email":156},"Ying Wang, MD","86-13526477216","bike2202@163.com",{"facility":158,"status":30,"city":159,"state":160,"zip":161,"country":59,"countryCode":60,"cosmosGeoPoint":162,"geoPoint":166,"contacts":167},"Renmin hospital of Wuhan University","Wuhan","Hubei","430060",{"type":62,"coordinates":163},[164,165],114.26667,30.58333,{"lat":165,"lon":164},[168],{"name":169,"role":46,"phone":170,"phoneExt":30,"email":171},"Yu Xu, MD","86-15927088198","xy37138@163.com",{"facility":173,"status":30,"city":174,"state":175,"zip":176,"country":59,"countryCode":60,"cosmosGeoPoint":177,"geoPoint":181,"contacts":182},"The First Affiliated Hospital with Nanjing Medical University","Nanjing","Jiangsu","210029",{"type":62,"coordinates":178},[179,180],118.77778,32.06167,{"lat":180,"lon":179},[183],{"name":184,"role":46,"phone":185,"phoneExt":30,"email":186},"Meiping Lu, PhD","86-13776683366","lumeiping@jsph.org.cn",{"facility":188,"status":30,"city":189,"state":190,"zip":191,"country":59,"countryCode":60,"cosmosGeoPoint":192,"geoPoint":196,"contacts":197},"China-Japan Union Hospital of Jilin University","Changchun","Jilin","130033",{"type":62,"coordinates":193},[194,195],125.32278,43.88,{"lat":195,"lon":194},[198],{"name":199,"role":46,"phone":200,"phoneExt":30,"email":201},"Cuida Meng, MD","86-13596096000","mengcd@jlu.edu.cn",{"facility":203,"status":30,"city":204,"state":205,"zip":206,"country":59,"countryCode":60,"cosmosGeoPoint":207,"geoPoint":211,"contacts":212},"The Affiliated Hospital of Qingdao University","Qingdao","Shandong","266000",{"type":62,"coordinates":208},[209,210],120.38042,36.06488,{"lat":210,"lon":209},[213],{"name":214,"role":46,"phone":215,"phoneExt":30,"email":216},"Yan Jiang, MD","86-13256875886","jiangyanoto@163.com",{"facility":5,"status":30,"city":218,"state":219,"zip":220,"country":59,"countryCode":60,"cosmosGeoPoint":221,"geoPoint":225,"contacts":226},"Shanghai","Shanghai Municipality","200031",{"type":62,"coordinates":222},[223,224],121.45806,31.22222,{"lat":224,"lon":223},[227],{"name":42,"role":46,"phone":47,"phoneExt":30,"email":48},{"facility":229,"status":30,"city":218,"state":219,"zip":230,"country":59,"countryCode":60,"cosmosGeoPoint":231,"geoPoint":233,"contacts":234},"Guanghua Hospital of Integrated Traditional Chinese and Western Medicine","200052",{"type":62,"coordinates":232},[223,224],{"lat":224,"lon":223},[235],{"name":236,"role":46,"phone":237,"phoneExt":30,"email":238},"Na Sun, MD","86-13917998216","sunnsh-2007@163.com",{"facility":240,"status":30,"city":218,"state":219,"zip":241,"country":59,"countryCode":60,"cosmosGeoPoint":242,"geoPoint":244,"contacts":245},"Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine","200233",{"type":62,"coordinates":243},[223,224],{"lat":224,"lon":223},[246],{"name":247,"role":46,"phone":248,"phoneExt":30,"email":249},"Weitian Zhang, MD","86-18930177043","drzhangwt@163.com",{"facility":251,"status":30,"city":252,"state":253,"zip":254,"country":59,"countryCode":60,"cosmosGeoPoint":255,"geoPoint":259,"contacts":260},"The Second Hospital of Shanxi Medical University","Taiyuan","Shanxi","030001",{"type":62,"coordinates":256},[257,258],112.56028,37.86944,{"lat":258,"lon":257},[261],{"name":262,"role":46,"phone":263,"phoneExt":30,"email":264},"Yunfang An, PhD","86-13834236996","ayfent@126.com",{"facility":266,"status":30,"city":267,"state":268,"zip":269,"country":59,"countryCode":60,"cosmosGeoPoint":270,"geoPoint":274,"contacts":275},"The Affiliated Hospital of Yunnan University","Kunming","Yunnan","650000",{"type":62,"coordinates":271},[272,273],102.71833,25.03889,{"lat":273,"lon":272},[276],{"name":277,"role":46,"phone":278,"phoneExt":30,"email":279},"Yanli Yang, PhD","86-18651602696","xyang895@126.com",{"facility":281,"status":30,"city":282,"state":283,"zip":284,"country":59,"countryCode":60,"cosmosGeoPoint":285,"geoPoint":289,"contacts":290},"Affiliated Hangzhou First People's Hospital,School of Medicine, Westlake University","Hangzhou","Zhejiang","310006",{"type":62,"coordinates":286},[287,288],120.16142,30.29365,{"lat":288,"lon":287},[291],{"name":292,"role":46,"phone":293,"phoneExt":30,"email":294},"Yong Li, MD","86-13858084222","leeyung828@hotmail.com",{"type":43,"investigatorFullName":296,"investigatorTitle":297,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"Huabin Li","Professor and Director of the Department of Allergy Center","100608344",false,"NCT07200336","Anti-IL-5 Therapy With Simple Polypectomy Versus Extended Endoscopic Sinus Surgery for CRSwNP","Efficacy of Anti-IL-5 Therapy Combined With Simple Polypectomy Versus Extended Endoscopic Sinus Surgery in Patients With CRSwNP: A Multicenter Randomized Controlled Trial","Inclusion Criteria:\n\n1. Endoscopy shows bilateral nasal polyps, with bilateral NPS ≥4 (≥2 per side)\n2. Nasal obstruction symptoms \\>3 months, nasal obstruction score ≥2 (total 3 points) and\u002For hyposmia ≥2 (maximum 3 points)\n3. Evidence of type 2 inflammation: Nasal polyp tissue Eos \\>55\u002FHPF or \\>27% of inflammatory cells; or Peripheral blood Eos ≥6.9% (without asthma) or ≥3.7% (with asthma) Note: Meet any 2 of the above 3 criteria\n4. Failure after 4 weeks of standard medical therapy including: Intranasal corticosteroids \\>4 weeks; Other agents (oral steroids, macrolides, antihistamines, leukotriene receptor antagonists, decongestants, antibiotics) permitted as needed\n\nExclusion Criteria:\n\n1. Cystic fibrosis, Young's syndrome, Kartagener syndrome, antrochoanal polyp, or rhinitis medicamentosa\n2. Acute upper respiratory infection within 2 weeks\n3. Asthma exacerbation within 1 month\n4. HIV infection\n5. Parasitic infection within 6 months\n6. History of hypersensitivity to investigational drugs (except aspirin intolerance)\n7. Hypersensitivity to monoclonal antibodies or anti-IL-5 agents\n8. Oral steroid therapy within 1 month\n9. Pregnancy planning, current pregnancy, or lactation\n10. Uncontrolled systemic diseases\n11. Have a history of previous sinus surgery for CRSwNP\n12. Significant septal deviation affecting unilateral ventilation (mild deviation allowed)\n13. Investigator judgment of unsuitability for cohort study","ALL","18 Years","75 Years",{"count":308,"type":309},360,"ESTIMATED","INTERVENTIONAL",[312],"PHASE4","This study compares two surgical approaches combined with anti-IL-5 therapy in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Patients will be randomly assigned to one of the three groups: (1) anti-IL-5 alone, (2) anti-IL-5 with simple polyp removal, or (3) anti-IL-5 with extended sinus surgery. The aim of this study is to see if a less invasive surgery (simple polyp removal) with anti-IL-5 works as well as more extensive surgery with anti-IL-5. Participants will be followed for 1 to 3 years.",[315],"Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)",[317,318,319,320,321,322],"Anti-IL-5","Biologic-Surgical Combination","Extended Sinus Surgery","SNOT-22","Type 2 Inflammation","Recurrence","NOT_YET_RECRUITING","2025-09-29",{"date":326,"type":327},"2025-10-01","ACTUAL",{"date":329,"type":309},"2025-10-08",{"date":331,"type":309},"2031-10-10",{"name":5,"class":6},17]