[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100630580":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":32,"locations":40,"responsibleParty":66,"collaborators":69,"id":73,"slug":26,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":26,"eligibilityCriteria":78,"healthyVolunteers":79,"sex":80,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":26,"studyType":86,"phases":87,"briefSummary":89,"conditions":90,"keywords":94,"overallStatus":42,"whyStopped":26,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"Cappagh National Orthopaedic Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Arthrosamid","EXPERIMENTAL","Patient with knee osteoarthritis\n\nArthrosamid Injection. This is a non-biodegradable 2.5% iPAAG injectable implant. It is given once.",[13],"Device: Arthrosamid® 2.5% iPAAG injectable implant",{"label":15,"type":16,"description":17,"interventionNames":18},"Steroid","ACTIVE_COMPARATOR","Patient with knee osteoarthritis\n\nSteroid arm is as follow with one injection containing:\n\nDexamethasone 8mg and methylprednisolone 80mg and bupivacaine 0.25% 5 mls.",[19],"Drug: Steroid Drug",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Arthrosamid® 2.5% iPAAG injectable implant","Arthrosamid is a non-biodegradable, 2.5% polyacrylamide hydrogel (iPAAG) injection designed as a long-lasting, non-surgical treatment for knee osteoarthritis. It acts as a synovial implant that provides cushioning, reduces pain, and improves mobility for up to 3-4 years, often delaying the need for knee replacement surgery.",[9],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"DRUG","Steroid Drug","dexamethasone 8mg, methylprednisolone 80mg and bupivacaine 5ml 0.25%, intra articular injection",[15],[33,38],{"name":34,"role":35,"phone":36,"phoneExt":26,"email":37},"SEAN TEE LIM, M.D","CONTACT","(01) 814 0400","seantee.lim@nohc.ie",{"name":39,"role":35,"phone":36,"phoneExt":26,"email":26},"Shane Crilly, MD",[41],{"facility":5,"status":42,"city":43,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"RECRUITING","Dublin","D11 EV29","Ireland","IE",{"type":48,"coordinates":49},"Point",[50,51],-6.24889,53.33306,{"lat":51,"lon":50},[54,56,58,61,64],{"name":55,"role":35,"phone":36,"phoneExt":26,"email":37},"SEAN TEE LIM, MD",{"name":57,"role":35,"phone":36,"phoneExt":26,"email":26},"Stephen Eustace, MD",{"name":59,"role":60,"phone":26,"phoneExt":26,"email":26},"Stephen Eustace, M.D","PRINCIPAL_INVESTIGATOR",{"name":62,"role":63,"phone":26,"phoneExt":26,"email":26},"Shane Crilly, M.D","SUB_INVESTIGATOR",{"name":65,"role":63,"phone":26,"phoneExt":26,"email":26},"Ciara Doran, MSc",{"type":60,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Sean-Tee Lim","Radiology Registrar",[70],{"name":71,"class":72},"Contura","INDUSTRY","100630580",false,"NCT07489521","Arthrosamid vs. Steroid for the Management of Knee Osteoarthritis","A Randomised Control Trial of the Use of an Intraarticular Hydrogel Arthrosamid® vs. Steroid for the Non-operative Management of Knee Osteoarthritis","Inclusion Criteria:\n\n* Adults\n* Symptomatic single side knee pain.\n* Patients with diagnosis of knee osteoarthritis radiographic Kellgren and Lawrence system OA grade II-III-IV on x ray or MRI.\n\nExclusion Criteria:\n\n* Inflammatory conditions,\n* Cancer,\n* acute infection,\n* pregnancy and breastfeeding.\n* Uncontrolled diabetes mellitus,\n* Joint diseases in the knee, such as rheumatoid arthritis or gout, history of knee surgery with metallic implant.\n* If patient has undergone knee arthroscopy in past 6 months.\n* Intra-articular injection of corticosteroids during the previous 3 months, intra-articular injection of other drugs, such as hyaluronic acid over the previous 1 year.\n* Contraindications for intra-articular injection, such as thrombocytopenia, coagulopathy, articular infection of knee, impairment of immunity.",true,"ALL","18 Years","100 Years",{"count":84,"type":85},200,"ESTIMATED","INTERVENTIONAL",[88],"PHASE4","This study will be a randomised control trial of the use of intra-articular Arthrosamid® a novel intraarticular hydrogel vs. standard of care (steroid and local anaesthetic) for the non-operative management of knee osteoarthritis.",[91,92,93],"Osteo Arthritis Knee","Osteoarthritis","Intraarticular Injection",[92,95,96],"knee","steroid injection","2026-04-23",{"date":99,"type":100},"2026-04-28","ACTUAL",{"date":102,"type":100},"2026-01-29",{"date":104,"type":85},"2027-09",{"name":5,"class":6},1]