Effect of Combined Intravenous-Inhalational Anesthesia (CIVIA) on Postoperative Recovery Patterns.

ConditionsPostoperative Recovery Inhalation Anesthesia Total Intravenous Anesthesia

Trial statusRecruiting

Trial phasePhase 4

Trial typeInterventional

Biological sexAll

Age18+

SponsorKocaeli City Hospital

About this trial

This study was planned as a single-center, prospective, randomized trial. Adult patients undergoing elective spinal surgery lasting longer than three hours, performed in a neurosurgery operating room, will be evaluated. Patients managed with three different anesthesia methods currently used will be examined for recovery patterns:

1. Total intravenous anesthesia (TIVA), 2. TIVA Combined anesthesia with sevoflurane and intravenous agents (sevoflurane-CIVIA), 3. TIVA Combined anesthesia with desflurane and intravenous agents (desflurane-CIVIA).

Recovery patterns include; extubation time, eye opening time, emergence agitation, postoperative nausia and vomiting and postoperative recovery unit discharge time.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Scheduled for spine surgery

Expected surgery duration longer than 3 hours

Use of intraoperative neuromonitoring

BIS-guided anesthesia administered

Disqualifiers

Emergency surgeries

Patients receiving sole inhaled anesthesia (no TIVA)

Perioperative dural injury

Intraoperative severe hypotension requiring inotropic support

Trial design

Design model

Parallel

Treatments tested in this trial

Sevofluorane
Drug
In this group of patients, \<0.5 MAC sevoflurane will be used in combination with TIVA. (TIVA method described above)
Desflurane
Drug
In this group of patients, \<0.5 MAC Desflurane will be used in combination with TIVA.
Total Intravenous Anesthesia(TIVA)
Drug
In this group, TIVA will be applied with the combination of BIS-guided propofol + remifentanil.

Treatment groups

210 Participants

are divided into 3 treatment groups

Group A: Sevoflurane combined with TIVAExperimental treatment 1 intervention

Group B: Desflurane combined with TIVAExperimental treatment 1 intervention

Group C: TIVAExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

Extubation time

Extubation time in patients after all anesthetic drugs have been discontinued

Time frame

First postoperative hour

Secondary outcomes

Eye opening

time brtween anesthesia terminated and aye opening after surgery

Time frame

First postoperative hour

Other outcomes

Richmond Agitation-Sedation Scale (RASS)

Richmond Agitation-Sedation Scale (RASS) A 10-point scale ranging from +4 (combative) to -5 (unarousable). Measures agitation, sedation level, and responsiveness. Helps guide sedation management and assess recovery from anesthesia.

Time frame

first 2 hours postoperatively

Postoperative Nausia and Vomiting

Postoperative Nausia and Vomitting incidance

Time frame

First 2 postoperative hours

PACU discharge time

The time between the termination of anesthesia and the patient being discharged from the postoperative recovery room (PACU) with an Aldrete score of \>9. It is calculated in minutes.

Time frame

First 2 postoperative hours

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Kocaeli City Hospital

Lead sponsor

Source ClinicalTrials.gov

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