This study is a prospective, randomized, controlled (randomized, parallel group, concealed allocation), double-blinded trial. All depression patients undergoing breast cancer operation will be randomized 1:1 to the treatment intervention with general anesthesia as an adjunct to esketamine or saline. The objective of the trial is to evaluate the postoperative depression、gut microbiota、bispectral index data of patients undergoing breast cancer operation with esketamine or saline.
At least18 years and pre-menopausal;
scheduled to undergo elective breast cancer operation;
American Society of Anaesthesiologists (ASA) risk classification I-II.
Montgomery-asberg Depression Rating Scale (MADRS) score ≥22
Cognitive difficulties
Partial or complete gastrectomy
Previous esophageal surgery
Inability to conform to the study's requirements