[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100604220":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":26,"centralContacts":31,"locations":39,"responsibleParty":55,"collaborators":25,"id":58,"slug":25,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":25,"enrollmentInfo":66,"targetDuration":25,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":77,"overallStatus":82,"whyStopped":25,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"University of Virginia","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Concentrated","ACTIVE_COMPARATOR","Standard management of higher percent local anesthetic: 0.5% Bupivacaine",[13],"Drug: Bupivacaine",{"label":15,"type":16,"description":17,"interventionNames":18},"Dilute","EXPERIMENTAL","More dilute local : 0.25% Bupivacaine",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Bupivacaine","We are comparing two concentrations of the same drug: 10 ml of 0.5% and 20 ml of 0.25%; We will use the same milligram dose (50 mg).",[9,15],null,[27],{"name":28,"affiliation":29,"role":30},"Leon N Grinman, DO","UVA","PRINCIPAL_INVESTIGATOR",[32,36],{"name":28,"role":33,"phone":34,"phoneExt":25,"email":35},"CONTACT","434-924-3627","Lngrinman@gmail.com",{"name":37,"role":33,"phone":34,"phoneExt":25,"email":38},"Brett Elmore, MD","elmorbr@gmail.com",[40],{"facility":41,"status":25,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"UVA Health","Charlottesville","Virginia","22903","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-78.47668,38.02931,{"lat":51,"lon":50},[54],{"name":28,"role":33,"phone":34,"phoneExt":25,"email":35},{"type":30,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Leon Grinman","Assistant Professor","100604220",false,"NCT07146685","Effect of Local Anesthetic Concentration on Rebound Pain: A Randomized Control Study","RPRCT","Inclusion Criteria:\n\n* Total shoulder replacement patients (anatomic and reverse)\n* Adult patients (greater than or equal to 18 years)\n* Any gender\n* Any race\n\nExclusion Criteria:\n\n* \\- Chronic Pain diagnoses including:\n* substance\u002Fopioid use disorder\n* complex regional pain syndromes\n* fibromyalgia\n* Daily persistent opioid use spanning 3 months prior to surgery date\n* Allergy to local anesthetics or NSAIDS\n* Respiratory pathologies including:\n* CPAP- non-compliant \u002F untreated obstructive sleep apnea\n* COPD\n* Restrictive lung disease (pulmonary fibrosis, interstitial pneumonia, etc)\n* Contralateral diaphragm dysfunction\n* BMI \\> 40\n* Ipsilateral extremity pre-existing nerve injury\n* GFR \\\u003C 60\n* NSAID contraindications\n* Inability to follow up\n* Revision surgery\n* Patients requesting block as primary (avoidance of general anesthesia)\n* Need or request for brachial plexus catheter or liposomal bupivacaine\n* Vulnerable populations (pregnancy, incarceration, etc)\n* non-English speaking","ALL","18 Years",{"count":67,"type":68},168,"ESTIMATED","INTERVENTIONAL",[71],"PHASE4","Randomized control study that compares different concentrations of local anesthetic to investigate whether a lower concentration of local anesthetic would contribute to lower rebound pain scores at 24 hours post op in patients undergoing anatomic or reverse total shoulder arthroplasty.",[74,75,76],"Rebound Pain","Shoulder Arthroplasty","Interscalene Block",[78,79,80,81],"local anesthetics","rebound pain","brachial plexus","shoulder arthroscopy","NOT_YET_RECRUITING","2025-08-20",{"date":85,"type":86},"2025-08-28","ACTUAL",{"date":88,"type":68},"2026-01-01",{"date":90,"type":68},"2029-01-01",{"name":5,"class":6},1]