A multi-center, prospective, randomized, double-blind, active-controlled, no-inferiority clinical trial conducted across 5 tertiary medical centers in China. The objective of this RCT is to evaluate the sedative efficacy and safety profile of remimazolam besylate compared with dexmedetomidine in patients requiring mechanical ventilation following non-cardiac surgery. The study hypothesized that remimazolam besylate is non-inferior to dexmedetomidine regarding the primary efficacy outcome.
Aged between 18 and 64 years
Scheduled to undergo elective non-cardiac surgery
Planned for general anesthesia
With or without combined regional nerve blockade
Undergoing intracranial surgery, or having a history of severe neurological or spinal cord diseases
Pre-existing history of schizophrenia, epilepsy, or Parkinson's disease
Inability to communicate preoperatively due to coma, severe dementia, or language barriers
Preoperative .cardiac insufficiency or severe cardiac arrhythmias