[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643727":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":56,"collaborators":26,"id":60,"slug":26,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":63,"acronym":26,"eligibilityCriteria":64,"healthyVolunteers":61,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":26,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":26,"overallStatus":77,"whyStopped":26,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Pakistan Institute of Medical Sciences","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Tapinarof 1% cream","EXPERIMENTAL","Participants will apply topical tapinarof 1% cream once daily to effected plaque psoriasis",[13],"Drug: Tapinarof Cream 1%",{"label":15,"type":16,"description":17,"interventionNames":18},"Betamethasone dipropionate 0.05%","ACTIVE_COMPARATOR","Participants will apply topical betamethasone dipropionate 0.05% cream\u002Fointment twice daily to effected plaque psoriasis lesions",[19],"Drug: Betamethasone Dipropionate 0.05% Cream",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Betamethasone Dipropionate 0.05% Cream","Topical betamethasone dipropionate 0.05% cream once daily applied to affected plaque psoriasis lesions twice daily for up to 4 weeks",[15],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Tapinarof Cream 1%","Topical tapinarof 1% cream applied once daily to affected skin areas for up to 12 weeks",[9],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Noor Ul Ain, PGT Dermatology","CONTACT","+923365788143","nooraftab146@gmail.com",[38],{"facility":39,"status":26,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Pakistan institute of medical sciences(PIMS)","Islamabad","Federal","44000","Pakistan","PK",{"type":46,"coordinates":47},"Point",[48,49],73.04329,33.72148,{"lat":49,"lon":48},[52],{"name":53,"role":34,"phone":54,"phoneExt":26,"email":55},"Clinical research coordinator","0519261170","Info@pims.gov.pk",{"type":57,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Noor Ul Ain","Dermatology resident","100643727",false,"NCT07635043","Efficacy of Topical Tapinarof Versus Betamethasone in the Treatment of Plaque Psoriasis","Inclusion Criteria:\n\n* Age 18 years-65 years\n* Clinically diagnosed plaque psoriasis involving body surface area ( BSA) of 2-20% (mild to moderate severity)\n* Disease duration of at least 6 months\n* Willing and able to provide written informed consent\n* Not currently using any other topical and systematic psoriasis therapy, or willing to undergo a washout period (2 weeks for topical therapies)\n\nExclusion Criteria:\n\n* Severe psoriasis (BSA \\>20% or requiring systemic therapy)\n* Pregnant and lactating mothers\n* Known hypersensitivity to Tapinarof or any of its excipients\n* Concurrent dermatological conditions that may interfere with assessment e.g fungal infections,atopic dermatitis\n* Use of systemic immunosuppressants (methotrexate, cyclosporine, biologics ) or phototherapy within 4 weeks before enrollment\n* History of malignancy or current active infection\n* Known hypersensitivity to betamethasone or Tapinarof\n* Use of powerful topical corticosteroids within two weeks previously","ALL","18 Years","65 Years",{"count":69,"type":70},120,"ESTIMATED","INTERVENTIONAL",[73],"PHASE4","To assess the effectiveness of topical tapinarof to topical betamethasone in patients with mild to moderate plaque psoriasis presenting to tertiary care hospital in Islamabad",[76],"Psoriasis (PsO)","NOT_YET_RECRUITING","2026-06-03",{"date":80,"type":81},"2026-06-09","ACTUAL",{"date":83,"type":70},"2026-08-01",{"date":85,"type":70},"2026-11-30",{"name":5,"class":6},1]