[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100545329":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":26,"centralContacts":31,"locations":41,"responsibleParty":54,"collaborators":57,"id":62,"slug":45,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":63,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":45,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":43,"whyStopped":45,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Usual care for nocturnal non-dipping Blood Pressurem in OSA","EXPERIMENTAL","1\\. Group of participants receives an intervention\u002Ftreatment considered to be usual care",[13],"Drug: Melatonin 3 MG Oral Tablet",{"label":15,"type":10,"description":16,"interventionNames":17},"Oral administration of 3 mg\u002Fday of melatonin for 30 days in non-dipping Blood Pressure in OSA","2\\. Group of participants receives oral Melatonin 3 mg\u002Fday during 30 days plus usual care",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DRUG","Melatonin 3 MG Oral Tablet","Participants with OSA and nocturnal non-dipping Blood Pressure will be randomly assigned to a treatment with melatonin 3mg\u002Fd or to receive only the usual care.",[15,9],[25],"Usual Care for participants with OSA and nocturnal non-dipping Blood Pressure",[27],{"name":28,"affiliation":29,"role":30},"Matilde Valencia-Flores, PhD","National Institute of Medical Sciences and Nutrition Salvador Zubirán (INCMNSZ)","PRINCIPAL_INVESTIGATOR",[32,37],{"name":28,"role":33,"phone":34,"phoneExt":35,"email":36},"CONTACT","(+52 55) 54870900","3056","matilde.valenciaf@incmnsz.mx",{"name":38,"role":33,"phone":34,"phoneExt":39,"email":40},"Maria V Santiago, MSc","3052","victoria.santiagoa@incmnsz.mx",[42],{"facility":29,"status":43,"city":44,"state":45,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":45},"RECRUITING","Mexico City",null,"Mexico","MX",{"type":49,"coordinates":50},"Point",[51,52],-99.12766,19.42847,{"lat":52,"lon":51},{"type":30,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":45,"oldOrganization":45},"Matilde Valencia-Flores","Coordinator\u002F Head of the Sleep Disorders Clinic",[58,60],{"name":59,"class":6},"Universidad Nacional Autonoma de Mexico",{"name":61,"class":6},"Emory University","100545329",false,"NCT06380491","Melatonin's Effect on Nighttime Blood Pressure and Sleep in OSA Patients (MEBP-OSA)","Impact of Melatonin Treatment on Blood Pressure Circadian Rhythm, Sleep and Metabolic Variables.","MEBP-OSA","Inclusion Criteria:\n\n* Polisomnographic diagnosis of Obstructive Sleep Apnea\n* Non-dipping blood pressure on Ambulatory blood pressure monitoring (ABPM):\n\nExclusion Criteria:\n\n* Use of sleep or psychiatric medication\n* Use of Positive Airway Pressure (CPAP or Bipap)\n* Neurologic or psychiatric disorder","ALL","18 Years","60 Years",{"count":73,"type":74},50,"ESTIMATED","INTERVENTIONAL",[77],"PHASE4","The goal of this clinical trial is to learn if melatonin works to treat comorbid insomnia in adults with OSA and nocturnal non-dipping blood pressure pattern.\n\nThe main question it aims to answer is:\n\nDoes melatonin maintain sleep during night and recover the dipping blood pressure pattern?",[80],"Obstructive Sleep Apnea of Adult",[82,83,84],"Circadian Blood Pressure Rhythm","Obstructive sleep apnea","Melatonin","2026-03-30",{"date":87,"type":88},"2026-04-01","ACTUAL",{"date":90,"type":88},"2023-06-22",{"date":92,"type":74},"2028-01-22",{"name":5,"class":6},1]