[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100578955":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":28,"locations":35,"responsibleParty":432,"collaborators":18,"id":434,"slug":18,"hasResults":435,"nctId":436,"briefTitle":437,"officialTitle":438,"acronym":439,"eligibilityCriteria":440,"healthyVolunteers":435,"sex":441,"minAge":442,"maxAge":18,"enrollmentInfo":443,"targetDuration":18,"studyType":446,"phases":447,"briefSummary":449,"conditions":450,"keywords":452,"overallStatus":457,"whyStopped":18,"lastUpdateSubmitDate":458,"lastUpdatePostDateStruct":459,"startDateStruct":462,"completionDateStruct":464,"leadSponsor":466,"locationsCount":467},{"fullName":5,"class":6},"University Hospital, Toulouse","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Stopping dupilumab","EXPERIMENTAL","The experimental strategy comprises stopping dupilumab with no dose-reducing or interval of time-increasing strategy from the day of inclusion\u002Frandomisation",[13],"Drug: Stopping dupilumab",{"label":15,"type":16,"description":17,"interventionNames":18},"Dupilumab continuation","NO_INTERVENTION","Dupilumab continuation at the same dose and same interval as baseline",null,[20],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":18},"DRUG","Stopping dupilumab with no dose-reducing or interval of time-increasing strategy",[9],[25],{"name":26,"affiliation":5,"role":27},"Laurent GUILLEMINAULT, MD, PhD","PRINCIPAL_INVESTIGATOR",[29],{"name":30,"role":31,"phone":32,"phoneExt":33,"email":34},"Laurent GUILLEMINAULT, Md, PhD","CONTACT","0567771850","+33","guilleminault.l@chu-toulouse.fr",[36,50,64,78,92,106,120,134,148,162,176,190,199,213,227,241,255,269,283,294,305,319,333,348,362,376,390,404,418],{"facility":37,"status":18,"city":38,"state":37,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"CHU de Toulouse","Toulouse","31059","France","FR",{"type":43,"coordinates":44},"Point",[45,46],1.44367,43.60426,{"lat":46,"lon":45},[49],{"name":26,"role":31,"phone":32,"phoneExt":33,"email":34},{"facility":51,"status":18,"city":52,"state":40,"zip":53,"country":40,"countryCode":41,"cosmosGeoPoint":54,"geoPoint":58,"contacts":59},"CHU Amiens-Picardie","Amiens","80480",{"type":43,"coordinates":55},[56,57],2.3,49.9,{"lat":57,"lon":56},[60],{"name":61,"role":31,"phone":62,"phoneExt":33,"email":63},"Claire ANDREJAK, MD, PhD","0322087893","andrejak.claire@chu-amiens.fr",{"facility":65,"status":18,"city":66,"state":40,"zip":67,"country":40,"countryCode":41,"cosmosGeoPoint":68,"geoPoint":72,"contacts":73},"CHR d'Angers","Angers","49100",{"type":43,"coordinates":69},[70,71],-0.55202,47.47156,{"lat":71,"lon":70},[74],{"name":75,"role":31,"phone":76,"phoneExt":33,"email":77},"Yasmina PASCAUD MANSOUR, MD","0245353461","yasmina.mansour@chu-angers.fr",{"facility":79,"status":18,"city":80,"state":40,"zip":81,"country":40,"countryCode":41,"cosmosGeoPoint":82,"geoPoint":86,"contacts":87},"CH de Bayonne","Bayonne","64100",{"type":43,"coordinates":83},[84,85],-1.473,43.49316,{"lat":85,"lon":84},[88],{"name":89,"role":31,"phone":90,"phoneExt":33,"email":91},"Cécilia NOCENT, MD","0559443852","cnocent@ch-cotebasque.fr",{"facility":93,"status":18,"city":94,"state":40,"zip":95,"country":40,"countryCode":41,"cosmosGeoPoint":96,"geoPoint":100,"contacts":101},"CHU de Besançon","Besançon","25000",{"type":43,"coordinates":97},[98,99],6.01815,47.24878,{"lat":99,"lon":98},[102],{"name":103,"role":31,"phone":104,"phoneExt":33,"email":105},"Cindy BARNIG, MD, PhD","0647737530","cbarnig@chu-besancon.fr",{"facility":107,"status":18,"city":108,"state":40,"zip":109,"country":40,"countryCode":41,"cosmosGeoPoint":110,"geoPoint":114,"contacts":115},"CHU de Brest","Brest","29200",{"type":43,"coordinates":111},[112,113],-4.48628,48.39029,{"lat":113,"lon":112},[116],{"name":117,"role":31,"phone":118,"phoneExt":33,"email":119},"Françis COUTURAUD, MD, PhD","0298347347","francis.couturaud@chu-brest.fr",{"facility":121,"status":18,"city":122,"state":40,"zip":123,"country":40,"countryCode":41,"cosmosGeoPoint":124,"geoPoint":128,"contacts":129},"CHU de Caen","Caen","14000",{"type":43,"coordinates":125},[126,127],-0.35912,49.18585,{"lat":127,"lon":126},[130],{"name":131,"role":31,"phone":132,"phoneExt":33,"email":133},"Helen FOUQUET, MD","0231064677","fouquet-h@chu-caen.fr",{"facility":135,"status":18,"city":136,"state":40,"zip":137,"country":40,"countryCode":41,"cosmosGeoPoint":138,"geoPoint":142,"contacts":143},"CH de Cannes","Cannes","06400",{"type":43,"coordinates":139},[140,141],7.01275,43.55135,{"lat":141,"lon":140},[144],{"name":145,"role":31,"phone":146,"phoneExt":33,"email":147},"Fabien ROLLAND, MD","0493697860","f.rolland@ch-cannes.fr",{"facility":149,"status":18,"city":150,"state":40,"zip":151,"country":40,"countryCode":41,"cosmosGeoPoint":152,"geoPoint":156,"contacts":157},"CHU de Clermont-Ferrand","Clermont-Ferrand","63000",{"type":43,"coordinates":153},[154,155],3.08682,45.77969,{"lat":155,"lon":154},[158],{"name":159,"role":31,"phone":160,"phoneExt":33,"email":161},"Camille ROLLAND-DEBORD, MD","0473751653","crollanddebord@chu-clermontferrand.fr",{"facility":163,"status":18,"city":164,"state":40,"zip":165,"country":40,"countryCode":41,"cosmosGeoPoint":166,"geoPoint":170,"contacts":171},"CHI de Créteil","Créteil","94000",{"type":43,"coordinates":167},[168,169],2.46569,48.79266,{"lat":169,"lon":168},[172],{"name":173,"role":31,"phone":174,"phoneExt":33,"email":175},"Amel BOUDJEMAA, MD","0157022080","amel.boudjemaa@chicreteil.fr",{"facility":177,"status":18,"city":178,"state":40,"zip":179,"country":40,"countryCode":41,"cosmosGeoPoint":180,"geoPoint":184,"contacts":185},"CHU de Dijon","Dijon","21000",{"type":43,"coordinates":181},[182,183],5.01391,47.31344,{"lat":183,"lon":182},[186],{"name":187,"role":31,"phone":188,"phoneExt":33,"email":189},"Philippe BONNIAUD, MD, PhD","0380293772","philippe.bonniaud@chu-dijon.fr",{"facility":191,"status":18,"city":192,"state":40,"zip":193,"country":40,"countryCode":41,"cosmosGeoPoint":18,"geoPoint":18,"contacts":194},"CH Annecy Genevois","Epagny-Metz-Annecy","74370",[195],{"name":196,"role":31,"phone":197,"phoneExt":33,"email":198},"Toufik DIDI, MD","0450636603","tdidi@ch-annecygenevois.fr",{"facility":200,"status":18,"city":201,"state":40,"zip":202,"country":40,"countryCode":41,"cosmosGeoPoint":203,"geoPoint":207,"contacts":208},"CHU Grenoble-Alpes","La Tronche","38700",{"type":43,"coordinates":204},[205,206],5.74629,45.20507,{"lat":206,"lon":205},[209],{"name":210,"role":31,"phone":211,"phoneExt":33,"email":212},"Christel SAINT-RAYMOND, MD","0476765522","csaint-raymond@chu-grenoble.fr",{"facility":214,"status":18,"city":215,"state":40,"zip":216,"country":40,"countryCode":41,"cosmosGeoPoint":217,"geoPoint":221,"contacts":222},"Hôpital Kremlin Bicêtre","Le Kremlin-Bicêtre","94270",{"type":43,"coordinates":218},[219,220],2.36073,48.81471,{"lat":220,"lon":219},[223],{"name":224,"role":31,"phone":225,"phoneExt":33,"email":226},"Antoine BEURNIER, MD","0145217896","antoine.beurnier@aphp.fr",{"facility":228,"status":18,"city":229,"state":40,"zip":230,"country":40,"countryCode":41,"cosmosGeoPoint":231,"geoPoint":235,"contacts":236},"CH Le Mans","Le Mans","72037",{"type":43,"coordinates":232},[233,234],0.20251,48.0021,{"lat":234,"lon":233},[237],{"name":238,"role":31,"phone":239,"phoneExt":33,"email":240},"François GOUPIL, MD","0243434345","fgoupil@ch-lemans.fr",{"facility":242,"status":18,"city":243,"state":40,"zip":244,"country":40,"countryCode":41,"cosmosGeoPoint":245,"geoPoint":249,"contacts":250},"Institut Coeur Poumon, CHU de Lille","Lille","59000",{"type":43,"coordinates":246},[247,248],3.05512,50.63391,{"lat":248,"lon":247},[251],{"name":252,"role":31,"phone":253,"phoneExt":33,"email":254},"Stéphanie FRY, MD","0320445948","stephanie.fry@chu-lille.fr",{"facility":256,"status":18,"city":257,"state":40,"zip":258,"country":40,"countryCode":41,"cosmosGeoPoint":259,"geoPoint":263,"contacts":264},"Hôpital Croix Rousse","Lyon","69004",{"type":43,"coordinates":260},[261,262],4.84789,45.74906,{"lat":262,"lon":261},[265],{"name":266,"role":31,"phone":267,"phoneExt":33,"email":268},"Gille DEVOUASSOUX, MD, PhD","0426732947","gilles.devouassoux@chu-lyon.fr",{"facility":270,"status":18,"city":271,"state":40,"zip":272,"country":40,"countryCode":41,"cosmosGeoPoint":273,"geoPoint":277,"contacts":278},"Hôpital Avicenne","Paris","75012",{"type":43,"coordinates":274},[275,276],2.3488,48.85341,{"lat":276,"lon":275},[279],{"name":280,"role":31,"phone":281,"phoneExt":33,"email":282},"Lucile SESE, MD","06677289103","Lucile.sese@aphp.fr",{"facility":284,"status":18,"city":271,"state":40,"zip":285,"country":40,"countryCode":41,"cosmosGeoPoint":286,"geoPoint":288,"contacts":289},"Hôpital Européen Georges Pompidou","75015",{"type":43,"coordinates":287},[275,276],{"lat":276,"lon":275},[290],{"name":291,"role":31,"phone":292,"phoneExt":33,"email":293},"Thibaud SOUMAGNE, MD","0156093462","thibaud.soumagne@live.fr",{"facility":295,"status":18,"city":271,"state":40,"zip":296,"country":40,"countryCode":41,"cosmosGeoPoint":297,"geoPoint":299,"contacts":300},"Hôpital Bichât","75018",{"type":43,"coordinates":298},[275,276],{"lat":276,"lon":275},[301],{"name":302,"role":31,"phone":303,"phoneExt":33,"email":304},"Camille TAILLE, MD, PhD","0140256802","camille.taille@aphp.fr",{"facility":306,"status":18,"city":307,"state":40,"zip":308,"country":40,"countryCode":41,"cosmosGeoPoint":309,"geoPoint":313,"contacts":314},"CHU de Bordeaux","Pessac","33600",{"type":43,"coordinates":310},[311,312],-0.6324,44.80565,{"lat":312,"lon":311},[315],{"name":316,"role":31,"phone":317,"phoneExt":33,"email":318},"Pierre-Olivier GIRODET, MD, PhD","0557623194","pierre-olivier.girodet@chu-bordeaux.fr",{"facility":320,"status":18,"city":321,"state":40,"zip":322,"country":40,"countryCode":41,"cosmosGeoPoint":323,"geoPoint":327,"contacts":328},"Hôpital Lyon Sud","Pierre-Bénite","69495",{"type":43,"coordinates":324},[325,326],4.82424,45.70359,{"lat":326,"lon":325},[329],{"name":330,"role":31,"phone":331,"phoneExt":33,"email":332},"Nathalie FREYMOND, MD","0478864401","nathalie.freymond@chu-lyon.fr",{"facility":334,"status":18,"city":335,"state":40,"zip":336,"country":40,"countryCode":41,"cosmosGeoPoint":337,"geoPoint":341,"contacts":342},"CHU de Guadeloupe","Pointe à Pitre","97159",{"type":43,"coordinates":338},[339,340],1.98937,44.07984,{"lat":340,"lon":339},[343],{"name":344,"role":31,"phone":345,"phoneExt":346,"email":347},"Chantal RAHERISON SEMJEN, MD, PhD","891360","+590","chantal.raherison@chu-guadeloupe.fr",{"facility":349,"status":18,"city":350,"state":40,"zip":351,"country":40,"countryCode":41,"cosmosGeoPoint":352,"geoPoint":356,"contacts":357},"CHU de Reims","Reims","51092",{"type":43,"coordinates":353},[354,355],4.02853,49.26526,{"lat":355,"lon":354},[358],{"name":359,"role":31,"phone":360,"phoneExt":33,"email":361},"Jeanne-Marie PEROTIN-COLLARD, MD, PhD","0326787614","jmperotin-collard@chu-reims.fr",{"facility":363,"status":18,"city":364,"state":40,"zip":365,"country":40,"countryCode":41,"cosmosGeoPoint":366,"geoPoint":370,"contacts":371},"CH de Roubaix","Roubaix","59100",{"type":43,"coordinates":367},[368,369],3.17456,50.69421,{"lat":369,"lon":368},[372],{"name":373,"role":31,"phone":374,"phoneExt":33,"email":375},"Nicolas JUST, MD","0320993048","nicolas.just@ch-roubaix.fr",{"facility":377,"status":18,"city":378,"state":40,"zip":379,"country":40,"countryCode":41,"cosmosGeoPoint":380,"geoPoint":384,"contacts":385},"CHU de Nantes","Saint-Herblain","44800",{"type":43,"coordinates":381},[382,383],-1.651,47.21154,{"lat":383,"lon":382},[386],{"name":387,"role":31,"phone":388,"phoneExt":33,"email":389},"François-Xavier BLANC, MD, PhD","0240165710","xavier.blanc@chu-nantes.fr",{"facility":391,"status":18,"city":392,"state":40,"zip":393,"country":40,"countryCode":41,"cosmosGeoPoint":394,"geoPoint":398,"contacts":399},"Nouvel Hôpital Civil","Strasbourg","67000",{"type":43,"coordinates":395},[396,397],7.74553,48.58392,{"lat":397,"lon":396},[400],{"name":401,"role":31,"phone":402,"phoneExt":33,"email":403},"Naji KHAYATH, MD","0369550898","naji.khayath@chru-strasbourg.fr",{"facility":405,"status":18,"city":406,"state":40,"zip":407,"country":40,"countryCode":41,"cosmosGeoPoint":408,"geoPoint":412,"contacts":413},"Hôpital Foch","Suresnes","92150",{"type":43,"coordinates":409},[410,411],2.22929,48.87143,{"lat":411,"lon":410},[414],{"name":415,"role":31,"phone":416,"phoneExt":33,"email":417},"Colas TCHERAKIAN, MD, PhD","0146252315","c.tcherakian@hopital-foch.com",{"facility":419,"status":18,"city":420,"state":40,"zip":421,"country":40,"countryCode":41,"cosmosGeoPoint":422,"geoPoint":426,"contacts":427},"Hôpital Tarbes Lourdes","Tarbes","65000",{"type":43,"coordinates":423},[424,425],0.07139,43.23407,{"lat":425,"lon":424},[428],{"name":429,"role":31,"phone":430,"phoneExt":33,"email":431},"Joëlle COURDEAU, MD","0562546060","jcourdeau-labourie@ch-tarbes.vic.fr",{"type":433,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100578955",false,"NCT06818019","Withdrawal of Dupilumab in Severe Asthma","WIthdrawal of DUpilumab in Severe Asthma: a Randomized Non-inferiority-controlled Trial","WIDUSA","Inclusion Criteria:\n\n* Adult patients ≥ 18 years old\n* Treated with dupilumab for at least 36 months for severe asthma\n* Well controlled asthma defined by an Asthma Control Questionnaire score ≥ 18 and 0 or 1 exacerbation within the year prior to the inclusion visit\n\nExclusion Criteria:\n\n* Patients who refuse to discontinue dupilumab, for any reason\n* Patients with Forced expiratory volume in one second ≤ 30% of predicted values\n* Patients treated by an oral corticosteroid dose ≥ 10 mg\u002Fday (in prednisone equivalent)\n* Patients who have to discontinue dupilumab for a reason other than controlled asthma, such as an adverse drug reaction, a planned or current pregnancy, or a planned switch to another biologic indicated in severe asthma\n* Patients who have to continue dupilumab for the treatment of comorbidities apart from nasal polyposis\n* Active smoking\n* Pregnancy or breastfeeding","ALL","18 Years",{"count":444,"type":445},205,"ESTIMATED","INTERVENTIONAL",[448],"PHASE4","Asthma management has been revolutionised by the development of biological therapies. Dupilumab is an anti-interleukin4 receptor marketed in 2020 for severe asthmatic patients with 2 exacerbations or more within the last 12 months. Although data showed that safety and efficacy of dupilumab are sustained when treatment is extended up to 3 years, no study has emerged regarding dupilumab discontinuation. This study aims to demonstrate the non-inferiority regarding strategy failure at 24 months of stopping dupilumab (intervention group) compared with its continuation (control group) in controlled asthma patients receiving this drug for at least 3 years.",[451],"Severe Asthma",[453,454,455,456],"severe asthma","dupilumab","exacerbation","discontinuation","NOT_YET_RECRUITING","2025-02-07",{"date":460,"type":461},"2025-02-10","ACTUAL",{"date":463,"type":445},"2025-04-02",{"date":465,"type":445},"2029-12-31",{"name":5,"class":6},29]