[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100619092":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":23,"centralContacts":27,"locations":33,"responsibleParty":48,"collaborators":51,"id":54,"slug":18,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":18,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":18,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":79,"overallStatus":36,"whyStopped":18,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"University of South Carolina","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Pistachio","EXPERIMENTAL","Four days of pistachio snacking, to be consumed mid-morning (1oz; 9-11am), mid-afternoon (1oz; 2-4pm), and pre-sleep (0.5 oz; within 1hr of bedtime), while otherwise maintaining normal dietary habits. An addition snack will be consumed post-exercise (0.5oz).",[13],"Other: Pistachio",{"label":15,"type":16,"description":17,"interventionNames":18},"Control","NO_INTERVENTION","Maintain normal dietary habits for four days.",null,[20],{"type":6,"name":9,"description":21,"armGroupLabels":22,"otherNames":18},"Roasted, lightly salted, pistachio kernels (no shell)",[9],[24],{"name":25,"affiliation":5,"role":26},"Katie R Hirsch, PhD","PRINCIPAL_INVESTIGATOR",[28],{"name":29,"role":30,"phone":31,"phoneExt":18,"email":32},"Callie Unrein, MS","CONTACT","803-777-5478","sustainlab@mailbox.sc.edu",[34],{"facility":35,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":18},"Public Health Research Center: Clinical Exercise Research Center","RECRUITING","Columbia","South Carolina","29208","United States","US",{"type":43,"coordinates":44},"Point",[45,46],-81.03481,34.00071,{"lat":46,"lon":45},{"type":26,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Katie Hirsch","Assistant Professor",[52],{"name":53,"class":6},"American Pistachio Growers","100619092",false,"NCT07340125","Pistachio Snacking and Metabolic Flexibility","Effects of Pistachio Snacking on Metabolic Flexibility in Healthy Overweight and Obese Adults","Inclusion Criteria:\n\n* Males and Females\n* Age: 25-45 years\n* Overweight or obese (BMI=25.0-34.9 kg\u002Fm²)\n* Poor sleep quality (Pittsburgh Sleep Quality Index ≥ 5)\n* Healthy (no diagnosed metabolic, cardiovascular, sleep, or other health condition that may significantly alter metabolism, sleep, or ability to participate in the exercise test)\n* Not meeting weekly physical activity recommendations (\\\u003C150 min moderate-intensity exercise, \\\u003C75 minutes of vigorous-intensity exercise, and \\\u003C2 days of strength training)\n* Not following a diet that is restrictive or eliminates certain food group\u002Ftypes\n\nExclusion Criteria:\n\n* Allergies to nuts, especially tree nuts\n* Has a pacemaker\n* Following a diet that is restrictive or eliminates certain food group\u002Ftypes\n* Self-repoted health or disease state that may influence study outcomes, including known metabolic or endocrine disorder (e.g. prediabetes, type 1 or type 2 diabetes, or polycystic ovary syndrome), cardiovascular diseases, neuromuscular disorders, musculoskeletal disorders; current or recent history of cancer\u002Fcancer treatment (within the past year)\n* History of gastrointestinal surgery, hysterectomy\n* For women: pregnant or thinking of becoming pregnant during the time of participation, pregnant within the last year, currently breastfeeding, or known to be perimenopausal",true,"ALL","25 Years","45 Years",{"count":65,"type":66},60,"ESTIMATED","INTERVENTIONAL",[69],"NA","The purpose of this study is to evaluate the effects of pistachio snacking on metabolic flexibility (at rest, during exercise, and in post-exercise recovery) in healthy overweight and obese adults. Secondary goals include evaluating effects on changes in diet quality, sleep characteristics, physical activity, and hormonal health in women. In randomized order, participants will complete four days of pistachio snacking and four days of normal dietary habits (control). For both conditions, primary outcomes of resting substrate metabolism, metabolic flexibility during exercise, and post-exercise substrate metabolism will be measured pre-post intervention via indirect calorimetry. Secondary outcome of diet quality (kcal, carb, fat, protein) will be measured pre-post intervention via diet log. Exploratory outcomes of daily physical activity (steps, intensity), nightly sleep characteristics (quantity, quality, latency, efficiency), and daytime sleepiness and hunger.",[72,73,74,75,76,77,78],"Overweight (BMI > 25)","Obese But Otherwise Healthy Participants","Overweight or Obese","Obese Patients (BMI ≥ 30 kg\u002Fm²)","Poor Sleep Quality","Healthy Participants","Physically Inactive",[9,80,81,82,83,84],"Tree Nuts","metabolic flexibility","metabolism","diet quality","snacking","2026-01-05",{"date":87,"type":88},"2026-01-14","ACTUAL",{"date":90,"type":88},"2025-09-01",{"date":92,"type":66},"2026-12-31",{"name":5,"class":6},1]