[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637854":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":33,"centralContacts":41,"locations":48,"responsibleParty":49,"collaborators":48,"id":52,"slug":48,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":48,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":72,"overallStatus":83,"whyStopped":48,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":48},{"fullName":5,"class":6},"Future University in Egypt","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Calcium Hydroxide Group","EXPERIMENTAL","Meta Paste (Meta Biomed)",[13],"Drug: Calcium Hydroxide (Ca(OH)2)",{"label":15,"type":10,"description":16,"interventionNames":17},"Bioceramic Group","Bio-C Temp Angelus",[18],"Drug: Bioceramic Intracanal Medicament",[20,27],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Calcium Hydroxide (Ca(OH)2)","Calcium hydroxide will be used as an intracanal medicament during root canal treatment in Permanent Mandibular molars with Symptomatic Apical Periodontitis",[9],[26],"Meta paste - Meta Biomed",{"type":21,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Bioceramic Intracanal Medicament","Bioceramic material will be used as an intracanal medicament during root canal treatment in Permanent Mandibular molars with Symptomatic Apical Periodontitis",[15],[32],"Bio- C temp - Angelus",[34,38],{"name":35,"affiliation":36,"role":37},"Adel Abdelwahed, Prof. Ass. of endodontic","Prof. Ass. of endodontic, faculty of Oral and Dental Medicine Future University in Egypt","PRINCIPAL_INVESTIGATOR",{"name":39,"affiliation":40,"role":37},"Marwa Moataz abo shadi, Lecturer of Endodontics","Lecturer of Endodontics, Faculty of Oral and Dental Medicine, Future university in Egypt",[42],{"name":43,"role":44,"phone":45,"phoneExt":46,"email":47},"Salma Tarek Abdullah, Bachelors degree","CONTACT","+201060044225","+201007510555","salma1319142066@gmail.com",null,{"type":37,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":48,"oldOrganization":48},"salma tarek abdullah","Medical student , future university","100637854",false,"NCT07585721","Postoperative Pain and Substance P Levels After Bioceramic vs Calcium Hydroxide Intracanal Medicaments in Symptomatic Apical Periodontitis","Clinical Evaluation of the Postoperative Pain and Substance P Levels Following the Use of Bioceramic Verses Calcium Hydroxide Intracanal Medicaments in Permanent Mandibular Molars With Symptomatic Apical Periodontitis","(BCvsCaOH)","Inclusion Criteria:\n\n* \\- Patients aged 18-45 years with no sex predilection\n* Medically free Patients with no systemic conditions that can affect post operative pain response.\n* Patients should not be taking any pain medications 24 hours before intervention\n* Positive patients' acceptance for participating in the study\n* Patient able to sign informed consent\n* Permanent mandibular molars diagnosis with Symptomatic Apical Periodontitis\n* Permanent molars without any anatomical variations or severe curvatures\n\nExclusion Criteria:\n\n* \\- Medically compromised patients\n* Patients who have received antibiotic therapy within the last 2 weeks.\n* Pregnant or lactating women.\n* Patients with known allergy to any of the irrigants used.\n* Patients with swelling or acute peri-apical abscess or fistulous tract.\n* Teeth that have:\n* Wide or open apex .\n* Vital pulp tissue .\n* Periodontally affected with grade 2or 3 mobility.\n* Non restorable teeth .\n* Abnormal anatomy and calcified canals .\n* Pervious root canal treatment.\n* severe curved canal\n* Buccolingual and mesiodistal radiographs were taken to evaluate the root canal anatomy",true,"ALL","18 Years","45 Years",{"count":64,"type":65},28,"ESTIMATED","INTERVENTIONAL",[68],"NA","Clinical Evaluation of the Postoperative Pain and Substance P levels Following the use of Bioceramic verses Calcium Hydroxide Intracanal Medicaments in Permanent Mandibular molars with Symptomatic Apical Periodontitis",[71],"Symptomatic Apical Periodontitis",[73,74,75,76,77,78,79,80,81,82,71],"Postoperative Pain","Substance P","Calcium Hydroxide","Bioceramic intra-canal medication","BIO-C TEMP","Mandibular Molars","Intra canal medication","Endodontics","Root Canal Treatment","inflammatory mediators","NOT_YET_RECRUITING","2026-05-10",{"date":86,"type":87},"2026-05-14","ACTUAL",{"date":89,"type":65},"2026-06-01",{"date":91,"type":65},"2027-02-01",{"name":5,"class":6}]