Health Trials

Postprandial Regulation of Bone Perfusion in Healthy Individuals

ConditionsHealthy Adult ParticipantsBone PhysiologyBone Blood Flow RegulationGLP-2GIPAmylinPeptide HormonesGut Hormones
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age25-50
SponsorUniversity of Copenhagen

About this trial

The goal of this clinical trial is to learn whether certain natural hormones - Glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-2, (GLP-2), and amylin - affect blood flow to the bones.

Eligibility criteria

Qualifiers

Age 25-50 years.

BMI between 18.5-30 kg/m2.

Normal gait.

Premenopausal (if female).

Disqualifiers

Bone disease incl. confirmed osteopenia.

Fracture within the last 6 months at the time of inclusion.

Amputation or congenital defect of extremities.

HbA1c>41.9 mmol/mol and/or diagnosed type 1 or type 2 diabetes.

Trial design

Treatments tested in this trial

  • isotonic saline infusion
  • Infusion of GIP(1-42)
  • Infusion of GLP-2(1-33)
  • Infusion of pramlintide

Treatment groups

15 Participants
are divided into 4 treatment groups

Sponsors and collaborators

University of Copenhagen

Lead sponsor

Rigshospitalet, Denmark

Collaborator

Source ClinicalTrials.gov