Prandial Metabolic Phenotype in Adults
ConditionProtein Metabolism
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age60-80
SponsorTexas A&M University
About this trial
Previous studies suggest that changes in metabolism due to the effects of aging might serve as a potential for therapeutic agents. The investigating lab developed a pulse method combining multiple stable isotopes to study multiple metabolic pathways in the same individual simultaneously. By measuring whole-body metabolism in a large group of older adults, the investigators may be able to unravel age-related deterioration in protein turnover (synthesis and breakdown) that contributes to impaired functional capacity. Metabolic profiles could explain differences in pathways in the aging process with special interest in metabolism of amino acids as they have been associated with aging-related disorders.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Age: 60-80, inclusive
Stable body-weight (± 5%) for the past 3 months
Subject is judged to be in satisfactory health based on medical history, physical examination, and laboratory screening evaluations.
Ability to walk, sit down and stand up independently or with walking mobility aids
Disqualifiers
Established diagnosis of current malignancy
History of untreated metabolic diseases including hepatic or renal disorder
Presence of acute illness or metabolically unstable chronic illness
Presence of fever within the last 3 days
Trial design
Design model
Crossover
Treatments tested in this trial
Total Amino Acids
Dietary supplementHistidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, Valine, Alanine, Arginine, Aspartate, Cystine, Glutamine, Glutamate, Glycine, Proline, Serine, Tyrosine. All supplements are commercially available.
Essential Amino Acids
Dietary supplementHistidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, Valine. All supplements are commercially available.
Essential Amino Acids + Hydroxy-methylbutyric acid (HMB)
Dietary supplementHistidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, Valine, HMB. All supplements are commercially available.
Essential Amino Acids + Leucine
Dietary supplementHistidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, Valine, Extra leucine. All supplements are commercially available.
Essential Amino Acids High
Dietary supplementHistidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, Valine. All supplements are commercially available.
Placebo Water
Dietary supplementWater
Treatment groups
50 Participants
are divided into 2 treatment groupsGroup A: Healthy male older adultsOther 6 interventions
Group B: Healthy female older adultsOther 6 interventions
Trial outcomes
Primary outcomes
1
Feeding related changes in whole-body protein and amino acid metabolism
Whole-body production rate measured after stable tracer administration
Time frame
up to 6 hoursSponsors and contacts
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Source ClinicalTrials.gov