[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643705":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":17,"locations":26,"responsibleParty":47,"collaborators":50,"id":64,"slug":10,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":65,"sex":71,"minAge":72,"maxAge":10,"enrollmentInfo":73,"targetDuration":10,"studyType":76,"phases":10,"briefSummary":77,"conditions":78,"keywords":80,"overallStatus":28,"whyStopped":10,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Hospital del Mar Research Institute (IMIM)","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Adult Patients With Acute Hypoxemic Respiratory Failure Treated With HFNC",null,"Adult patients with acute hypoxemic respiratory failure receiving high-flow nasal cannula (HFNC) as part of routine clinical care. Clinical, physiological, and metabolomic data will be collected to evaluate predictors of HFNC failure and respiratory support escalation.",[13],{"name":14,"affiliation":15,"role":16},"Francisco José Parrilla-Gómez, MD, Phd","Hospital del Mar","PRINCIPAL_INVESTIGATOR",[18,22],{"name":14,"role":19,"phone":20,"phoneExt":10,"email":21},"CONTACT","+34 747424848","fparilla@hmar.cat",{"name":23,"role":19,"phone":24,"phoneExt":10,"email":25},"Joan Ramon Masclans Enviz, MD, PhD","+34 639383309","jrmasclans@hmar.cat",[27],{"facility":15,"status":28,"city":29,"state":30,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"RECRUITING","Barcelona","Catalonia","08003","Spain","ES",{"type":35,"coordinates":36},"Point",[37,38],2.15899,41.38879,{"lat":38,"lon":37},[41,43],{"name":23,"role":19,"phone":24,"phoneExt":10,"email":42},"jrmasclans@psmar.cat",{"name":44,"role":19,"phone":45,"phoneExt":10,"email":46},"Marta Gas Roca","+34 932483000","mgas@psmar.cat",{"type":16,"investigatorFullName":48,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Andrea Castellvi","MD",[51,54,56,58,60,62],{"name":52,"class":53},"Instituto de Salud Carlos III","OTHER_GOV",{"name":55,"class":6},"Fundació La Marató de TV3",{"name":57,"class":6},"Hospital Universitari de Bellvitge",{"name":59,"class":6},"Hospital Universitari Joan XXIII de Tarragona.",{"name":61,"class":6},"Parc Taulí Hospital Universitari",{"name":63,"class":6},"Institute for Bioengineering of Catalonia","100643705",false,"NCT07607080","Predicting High-Flow Nasal Cannula Failure in Acute Hypoxemic Respiratory Failure Using Metabolomics and Clinical Data","Metabolomics and Clinical Data to Predict High-Flow Nasal Cannula Failure and Optimize Respiratory Support in Acute Hypoxemic Respiratory Failure","META-RESPIRE","Inclusion Criteria:\n\n* Adult patients (≥18 years old).\n* Admission to the intensive care unit (ICU) with acute hypoxemic respiratory failure (AHRF).\n* Treatment with high-flow nasal cannula (HFNC) as the initial respiratory support strategy.\n* Inclusion within the first 24 hours after HFNC initiation.\n* Provision of informed consent by the patient or legally authorized representative.\n\nExclusion Criteria:\n\n* Age \\\u003C18 years.\n* Active do-not-resuscitate (DNR) orders or limitation of therapeutic effort.\n* Refusal or inability to provide informed consent.\n* Previous invasive mechanical ventilation before study inclusion.","ALL","18 Years",{"count":74,"type":75},300,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to determine whether metabolomic profiles combined with clinical data can predict high-flow nasal cannula (HFNC) failure and help optimize respiratory support in adult patients with acute hypoxemic respiratory failure (AHRF). The main questions it aims to answer are:\n\nCan metabolomic biomarkers identify patients at higher risk of HFNC failure? Does combining metabolomic and clinical data improve the prediction of respiratory support escalation and clinical outcomes?\n\nParticipants will:\n\nReceive standard HFNC treatment according to clinical practice. Undergo collection of clinical, physiological, and laboratory data. Provide blood samples for metabolomic analysis during respiratory support.",[79],"Acute Hypoxemic Respiratory Failure",[81,82,83,84,85],"Acute Hypoxemic Respiratory Failure (AHRF)","High-Flow Nasal Cannula (HFNC)","Metabolomics","Respiratory Failure Prediction","Noninvasive Respiratory Support","2026-06-04",{"date":88,"type":89},"2026-06-08","ACTUAL",{"date":86,"type":89},{"date":92,"type":75},"2029-05",{"name":5,"class":6},1]