[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100624563":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":22,"centralContacts":35,"locations":41,"responsibleParty":126,"collaborators":128,"id":132,"slug":22,"hasResults":133,"nctId":134,"briefTitle":135,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":133,"sex":138,"minAge":22,"maxAge":139,"enrollmentInfo":140,"targetDuration":22,"studyType":143,"phases":144,"briefSummary":146,"conditions":147,"keywords":153,"overallStatus":165,"whyStopped":22,"lastUpdateSubmitDate":166,"lastUpdatePostDateStruct":167,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":174,"locationsCount":175},{"fullName":5,"class":6},"University Hospital, Caen","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Observational arm","This is a cohort of preterm infants, the interventions provided additionally to standard care are biological sampling (nasal swab, stool, blood and milk).",[12,13,14,15],"Biological: Nasal swab","Biological: blood sampling","Biological: Mother milk sampling","Biological: Stool sampling",[17,23,27,31],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":22},"BIOLOGICAL","Nasal swab","Nasal swab is performed by nurses at birth (within 72 hours), and each week during initial neonatal care unit stay. After discharge, nasal swabs will be performed by parents at home and sent by post to the investigational center.",[9],null,{"type":18,"name":24,"description":25,"armGroupLabels":26,"otherNames":22},"blood sampling","For 50-60 patients: 1 mL of blood sampling will be performed once during current care blood test (without additional blood draw), around 36 gestational weeks (+\u002F- 1 week).",[9],{"type":18,"name":28,"description":29,"armGroupLabels":30,"otherNames":22},"Mother milk sampling","For 50-60 patients: 1 mL of mother milk will be sampled once during hospital stay in case of breastfeeding.",[9],{"type":18,"name":32,"description":33,"armGroupLabels":34,"otherNames":22},"Stool sampling","Stool sampling will occure at birth (within 72 hours after birth), then once a week during neonatal unit stay.",[9],[36],{"name":37,"role":38,"phone":39,"phoneExt":22,"email":40},"Amélie Blanchetière","CONTACT","+33231272564","amelie.blanchetiere@unicaen.fr",[42,59,70,84,98,112],{"facility":43,"status":22,"city":44,"state":22,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Service de néonatalogie, CHU d'Amiens","Amiens","80000","France","FR",{"type":49,"coordinates":50},"Point",[51,52],2.3,49.9,{"lat":52,"lon":51},[55],{"name":56,"role":38,"phone":57,"phoneExt":22,"email":58},"Ghida Ghostine","+333 22 08 76 05","ghostine.ghida@chu-amiens.fr",{"facility":60,"status":22,"city":61,"state":22,"zip":62,"country":46,"countryCode":47,"cosmosGeoPoint":63,"geoPoint":67,"contacts":68},"Service de néonatalogie, CHU de Caen","Caen","14000",{"type":49,"coordinates":64},[65,66],-0.35912,49.18585,{"lat":66,"lon":65},[69],{"name":37,"role":38,"phone":39,"phoneExt":22,"email":40},{"facility":71,"status":22,"city":72,"state":22,"zip":73,"country":46,"countryCode":47,"cosmosGeoPoint":74,"geoPoint":78,"contacts":79},"Service de néonatalogie, CH Cherbourg-en-Cotentin","Cherbourg","50000",{"type":49,"coordinates":75},[76,77],-1.61636,49.63984,{"lat":77,"lon":76},[80],{"name":81,"role":38,"phone":82,"phoneExt":22,"email":83},"Anne-Sophie Pages","+332 33 20 76 66","annesophie.pages@ch-cotentin.fr",{"facility":85,"status":22,"city":86,"state":22,"zip":87,"country":46,"countryCode":47,"cosmosGeoPoint":88,"geoPoint":92,"contacts":93},"Service de néonatalogie, GHT du Havre","Le Havre","76600",{"type":49,"coordinates":89},[90,91],0.10785,49.49346,{"lat":91,"lon":90},[94],{"name":95,"role":38,"phone":96,"phoneExt":22,"email":97},"Julien Mourdie","02 32 73 41 52","julien.mourdie@ch-havre.fr",{"facility":99,"status":22,"city":100,"state":22,"zip":101,"country":46,"countryCode":47,"cosmosGeoPoint":102,"geoPoint":106,"contacts":107},"Service de néonatalogie, CHRU de Lille","Lille","59000",{"type":49,"coordinates":103},[104,105],3.05512,50.63391,{"lat":105,"lon":104},[108],{"name":109,"role":38,"phone":110,"phoneExt":22,"email":111},"Kevin Le Duc","+33320445962","kevin.leduc@chu-lille.fr",{"facility":113,"status":22,"city":114,"state":22,"zip":115,"country":46,"countryCode":47,"cosmosGeoPoint":116,"geoPoint":120,"contacts":121},"Service de néonatalogie, CHU de Rouen","Rouen","76000",{"type":49,"coordinates":117},[118,119],1.09932,49.44313,{"lat":119,"lon":118},[122],{"name":123,"role":38,"phone":124,"phoneExt":22,"email":125},"Lucile Tzaroukian","+332 32 88 82 58","lucile.tzaroukian@chu-rouen.fr",{"type":127,"investigatorFullName":22,"investigatorTitle":22,"investigatorAffiliation":22,"oldNameTitle":22,"oldOrganization":22},"SPONSOR",[129],{"name":130,"class":131},"INSERM UMR1311 DYNAMICURE","UNKNOWN","100624563",false,"NCT07411261","PremaBiom: Metatranscriptomics of the Respiratory Microbiome to Predict the Occurrence of Bronchopulmonary Dysplasia in Preterm Infants","PremaBiom","Inclusion Criteria:\n\n* Preterm infants with gestational age at birth lower than 32 gestational weeks and 6 days.\n* Hospital stay in one of the participant neonatal care units\n* Infants covered by the social security system of at least one of their parents\n* Whose parents have been informed about the study and agree to sign the informed consent form\n\nExclusion Criteria:\n\n* Palliative care only\n* Lack of parental consent\n* Parents who are minors or under legal protection (guardianship, conservatorship, judicial protection)\n* Parents who do not speak French","ALL","72 Hours",{"count":141,"type":142},270,"ESTIMATED","INTERVENTIONAL",[145],"NA","The goal of this clinical trial is to understand the impact of respiratory microbiome maturation in respiratory health of preterm infants under 32 gestational weeks. The main questions it aims to answer are:\n\n* What is the role of microbiome maturation in respiratory health (development of bronchopulmonary dysplasia, childhood asthma and viral respiratory infections) of preterm infants ?\n* Which environmental or health factors are involved in the maturation of the respiratory microbiome ?\n\nParticipants will undergo follow-up from birth until 3 years of corrected age including nasal swabs, stool samples, and for some of them blood and milk sample.",[148,149,150,151,152],"Bronchopulmonary Dysplasia","Preterm Infant Development","Asthma Childhood","Bronchiolitis","Viral Respiratory Tract Infections",[154,155,156,157,158,159,160,161,162,163,164],"respiratory microbiome","bronchopulmonary dysplasia","Prematurity","asthma","bronchiolitis","inflammation","inate immunity","respiratory tract infections","dysbiosis","personalized medicine","metatranscriptomics","NOT_YET_RECRUITING","2026-02-11",{"date":168,"type":169},"2026-02-13","ACTUAL",{"date":171,"type":142},"2026-03",{"date":173,"type":142},"2031-03",{"name":5,"class":6},6]