[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637435":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":24,"locations":30,"responsibleParty":214,"collaborators":10,"id":216,"slug":10,"hasResults":217,"nctId":218,"briefTitle":219,"officialTitle":220,"acronym":221,"eligibilityCriteria":222,"healthyVolunteers":217,"sex":223,"minAge":224,"maxAge":10,"enrollmentInfo":225,"targetDuration":10,"studyType":228,"phases":10,"briefSummary":229,"conditions":230,"keywords":233,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":249,"lastUpdatePostDateStruct":250,"startDateStruct":253,"completionDateStruct":255,"leadSponsor":257,"locationsCount":258},{"fullName":5,"class":6},"Swiss Cancer Institute","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients with BRAF V600E-mutated metastatic colorectal cancer",null,"Patients with unresectable or metastatic BRAF V600E-mutated colorectal cancer receiving standard-of-care treatment with combined BRAF and EGFR inhibition (e.g., encorafenib and cetuximab), with or without concomitant chemotherapy. Participants are enrolled prior to treatment initiation and followed longitudinally with collection of tumor tissue, blood, and stool samples to study mechanisms of treatment resistance.",[13],"Other: Longitudinal translational sampling",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"Longitudinal translational sampling","Longitudinal translational sampling (tumor tissue, plasma ctDNA, stool, PBMCs).",[9],[20],{"name":21,"affiliation":22,"role":23},"Ralph Fritsch, MD","University of Zurich","STUDY_CHAIR",[25],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Krista Zackel","CONTACT","+41313899191","trials@swisscancerinstitute.ch",[31,51,66,81,94,110,125,140,155,170,185,200],{"facility":32,"status":33,"city":34,"state":10,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Kantonsspital Aarau","RECRUITING","Aarau","CH-5000","Switzerland","CH",{"type":39,"coordinates":40},"Point",[41,42],8.04422,47.39254,{"lat":42,"lon":41},[45,49],{"name":46,"role":27,"phone":47,"phoneExt":10,"email":48},"Peter Moosmann, MD et phil.","+41 62 838 60 53","peter.moosmann@ksa.ch",{"name":46,"role":50,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"facility":52,"status":33,"city":53,"state":10,"zip":54,"country":36,"countryCode":37,"cosmosGeoPoint":55,"geoPoint":59,"contacts":60},"Kantonsspital Baden","Baden","5404",{"type":39,"coordinates":56},[57,58],8.30592,47.47333,{"lat":58,"lon":57},[61,65],{"name":62,"role":27,"phone":63,"phoneExt":10,"email":64},"Stefanie Pederiva, MD","+41 56 486 34 11","stefanie.pederiva@ksb.ch",{"name":62,"role":50,"phone":10,"phoneExt":10,"email":10},{"facility":67,"status":33,"city":68,"state":10,"zip":69,"country":36,"countryCode":37,"cosmosGeoPoint":70,"geoPoint":74,"contacts":75},"St. Claraspital","Basel","4058",{"type":39,"coordinates":71},[72,73],7.57327,47.55839,{"lat":73,"lon":72},[76,80],{"name":77,"role":27,"phone":78,"phoneExt":10,"email":79},"Melanie Löffler-Baumann, MD","+41 61 685 85 85","melanie.loeffler-baumann@claraspital.ch",{"name":77,"role":50,"phone":10,"phoneExt":10,"email":10},{"facility":82,"status":33,"city":68,"state":10,"zip":83,"country":36,"countryCode":37,"cosmosGeoPoint":84,"geoPoint":86,"contacts":87},"Universitaetsspital Basel","CH-4031",{"type":39,"coordinates":85},[72,73],{"lat":73,"lon":72},[88,92],{"name":89,"role":27,"phone":90,"phoneExt":10,"email":91},"Viviane Hess, MD","+41 61 265 50 59","viviane.hess@usb.ch",{"name":93,"role":50,"phone":10,"phoneExt":10,"email":10},"Viviane Prof Hess",{"facility":95,"status":33,"city":96,"state":10,"zip":97,"country":36,"countryCode":37,"cosmosGeoPoint":98,"geoPoint":102,"contacts":103},"Inselspital Bern","Bern","3010",{"type":39,"coordinates":99},[100,101],7.44744,46.94809,{"lat":101,"lon":100},[104,108],{"name":105,"role":27,"phone":106,"phoneExt":10,"email":107},"Martin D. Berger, Prof","+41 31 632 41 14","martin.berger@insel.ch",{"name":109,"role":50,"phone":10,"phoneExt":10,"email":10},"Martin Berger, Prof",{"facility":111,"status":33,"city":112,"state":10,"zip":113,"country":36,"countryCode":37,"cosmosGeoPoint":114,"geoPoint":118,"contacts":119},"Kantonsspital Graubünden","Chur","7000",{"type":39,"coordinates":115},[116,117],9.53287,46.84986,{"lat":117,"lon":116},[120,124],{"name":121,"role":27,"phone":122,"phoneExt":10,"email":123},"Sara Bastian, MD","+41 81 256 66 46","sara.bastian@ksgr.ch",{"name":121,"role":50,"phone":10,"phoneExt":10,"email":10},{"facility":126,"status":33,"city":127,"state":10,"zip":128,"country":36,"countryCode":37,"cosmosGeoPoint":129,"geoPoint":133,"contacts":134},"Luzerner Kantonsspital","Lucerne","6004",{"type":39,"coordinates":130},[131,132],8.30635,47.05048,{"lat":132,"lon":131},[135,139],{"name":136,"role":27,"phone":137,"phoneExt":10,"email":138},"Simon Häfliger, MD","+41 41 926 58 98","simon.haefliger.1@luks.ch",{"name":136,"role":50,"phone":10,"phoneExt":10,"email":10},{"facility":141,"status":33,"city":142,"state":10,"zip":143,"country":36,"countryCode":37,"cosmosGeoPoint":144,"geoPoint":148,"contacts":149},"HOCH Health Ostschweiz - Kantonsspital St. Gallen","Sankt Gallen","9007",{"type":39,"coordinates":145},[146,147],9.37477,47.42391,{"lat":147,"lon":146},[150,154],{"name":151,"role":27,"phone":152,"phoneExt":10,"email":153},"Barbara Denecke, MD","+41 71 494 11 11","barbara.denecke@h-och.ch",{"name":151,"role":50,"phone":10,"phoneExt":10,"email":10},{"facility":156,"status":33,"city":157,"state":10,"zip":158,"country":36,"countryCode":37,"cosmosGeoPoint":159,"geoPoint":163,"contacts":164},"Bürgerspital Solothurn","Solothurn","4500",{"type":39,"coordinates":160},[161,162],7.53714,47.20791,{"lat":162,"lon":161},[165,169],{"name":166,"role":27,"phone":167,"phoneExt":10,"email":168},"Julian Schardt, MD et phil.","+41 32 627 47 26","julian.schardt@spital.so.ch",{"name":166,"role":50,"phone":10,"phoneExt":10,"email":10},{"facility":171,"status":33,"city":172,"state":10,"zip":173,"country":36,"countryCode":37,"cosmosGeoPoint":174,"geoPoint":178,"contacts":179},"HFR Freiburg - Kantonsspital","Villars-sur-Glâne","1752",{"type":39,"coordinates":175},[176,177],7.11717,46.79054,{"lat":177,"lon":176},[180,184],{"name":181,"role":27,"phone":182,"phoneExt":10,"email":183},"Rahel Odermatt, MD","+41 26 306 22 60","rahel.odermatt@h-fr.ch",{"name":181,"role":50,"phone":10,"phoneExt":10,"email":10},{"facility":186,"status":33,"city":187,"state":10,"zip":188,"country":36,"countryCode":37,"cosmosGeoPoint":189,"geoPoint":193,"contacts":194},"Kantonsspital Winterthur","Winterthur","8004",{"type":39,"coordinates":190},[191,192],8.72413,47.50564,{"lat":192,"lon":191},[195,199],{"name":196,"role":27,"phone":197,"phoneExt":10,"email":198},"Guacimara Ortega Sanchez, MD","+41 52 266 25 43","guacimara.ortegasanchez@ksw.ch",{"name":196,"role":50,"phone":10,"phoneExt":10,"email":10},{"facility":201,"status":33,"city":202,"state":10,"zip":203,"country":36,"countryCode":37,"cosmosGeoPoint":204,"geoPoint":208,"contacts":209},"Universitätsspital Zürich USZ","Zurich","8091",{"type":39,"coordinates":205},[206,207],8.55,47.36667,{"lat":207,"lon":206},[210,213],{"name":21,"role":27,"phone":211,"phoneExt":10,"email":212},"+41 44 255 48 74","ralph.fritsch@usz.ch",{"name":21,"role":50,"phone":10,"phoneExt":10,"email":10},{"type":215,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100637435",false,"NCT07617610","Primary and Acquired Resistance to Targeted Treatment in BRAF V600E-mutated Metastatic Colorectal Cancer","Primary and Acquired Resistance to Targeted Treatment in BRAF V600E-mutated Metastatic Colorectal Cancer (PARTACER-Suisse)","PARTACER","Inclusion Criteria:\n\n* Diagnosis of unresectable or metastatic BRAF V600E-mutated colorectal cancer\n* Planned initiation of treatment with combined anti-EGFR antibody and BRAF inhibitor\n* Patients receiving treatment in any line, with or without chemotherapy\n* At least one tumor lesion accessible for biopsy\n* ECOG performance status 0-2\n* Life expectancy of at least 3 months\n* Age ≥18 years\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Medical or surgical contraindication for tumor biopsy\n* Active second malignancy (except non-melanoma skin cancer)\n* Inability to comply with study procedures (e.g., due to language barriers or cognitive impairment)\n* Pregnancy or breastfeeding\n* Previous treatment with a BRAF inhibitor","ALL","18 Years",{"count":226,"type":227},30,"ESTIMATED","OBSERVATIONAL","This study prospectively investigates the molecular mechanisms of primary and acquired resistance to standard-of-care BRAF V600E-directed therapy in patients with metastatic colorectal cancer and aims to pre-clinically develop novel strategies to reverse therapy resistance. Clinically approved combination treatment with cetuximab, encorafenib and chemotherapy improves patient outcomes, yet patients eventually experience disease progression. In this prospective multicenter study, tumor tissue, blood, and stool samples will be collected before treatment and at progression, to identify genetic and non-genetic mechanisms of resistance. Additionally, tumor tissue-based in vitro models (patient-derived organoids, PDOs) will be generated and exploited for functional in vitro testing, including genomic and pharmacologic perturbation studies. The overarching goal is to generate knowledge that can help develop new and more effective treatment strategies for future patients.",[231,232],"Metastatic Colorectal Cancer","BRAF V600E Mutation",[231,234,235,236,237,238,239,240,241,242,243,244,245,246,247,248],"mCRC","BRAF V600E","Targeted therapy resistance","Encorafenib","Cetuximab","EGFR inhibition","BRAF inhibition","Liquid biopsy","Precision oncology","Patient-derived organoids","Circulating tumor DNA","ctDNA","Microbiome","Comprehensive genomic profiling","SCI\u002FSAKK","2026-05-22",{"date":251,"type":252},"2026-06-01","ACTUAL",{"date":254,"type":252},"2025-05-25",{"date":256,"type":227},"2030-09",{"name":5,"class":6},12]