[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100458204":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":21,"centralContacts":25,"locations":31,"responsibleParty":48,"collaborators":10,"id":51,"slug":10,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":10,"studyType":65,"phases":10,"briefSummary":66,"conditions":67,"keywords":70,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"University of Kentucky","OTHER",[8,12,15,18],{"label":9,"type":10,"description":11,"interventionNames":10},"Patients with short cervix",null,"Patients with a short cervix identified on transvaginal ultrasound \\\u003C30 mm",{"label":13,"type":10,"description":14,"interventionNames":10},"Patients with a history of spontaneous preterm birth","Patients with a history of spontaneous preterm birth (\\\u003C34 weeks)",{"label":16,"type":10,"description":17,"interventionNames":10},"Patients with symptoms of preterm birth","Patients with preterm premature rupture of membranes or \\\u003C\u002F=2 cm dilated before 34 weeks gestation.",{"label":19,"type":10,"description":20,"interventionNames":10},"Control\u002FNulliparous","Nulliparous patients",[22],{"name":23,"affiliation":5,"role":24},"John O'Brien, MD","PRINCIPAL_INVESTIGATOR",[26],{"name":27,"role":28,"phone":29,"phoneExt":10,"email":30},"Cynthia Cockerham","CONTACT","859-629-2015","cynthia.cockerham@uky.edu",[32],{"facility":5,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"RECRUITING","Lexington","Kentucky","40506","United States","US",{"type":40,"coordinates":41},"Point",[42,43],-84.47772,37.98869,{"lat":43,"lon":42},[46],{"name":27,"role":28,"phone":10,"phoneExt":10,"email":47},"ctcock2@uky.edu",{"type":49,"investigatorFullName":23,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Professor","100458204",false,"NCT05246579","Prospective Evaluation of Pathways for Preterm Birth","Prospective Evaluation of Pathways for Preterm Birth: The PEPP Study","PEPP","Inclusion Criteria:\n\n* Maternal age from 18 to 45 years of age.\n* Singleton gestation.\n\nExclusion Criteria:\n\n* Treatment with vaginal progesterone or intramuscular progestogen within the previous 4 weeks.\n* History of congestive heart failure, chronic renal failure, or uncontrolled diabetes mellitus, or diabetes mellitus with evidence of end organ dysfunction secondary to vascular disease.\n* Current pregnancy with a major fetal anomaly or known chromosomal abnormality.\n* The subject has a marked uterine anatomic malformation that may alter pregnancy duration such as a septated uterus, unicornuate uterus, or uterine didelphys.\n* The subject is considered not capable or unwilling to undergo study procedures and requirements.\n* The subject is symptomatic with vaginal bleeding at enrollment visit.",true,"FEMALE","18 Years","45 Years",{"count":63,"type":64},240,"ESTIMATED","OBSERVATIONAL","This is a single center, prospective cohort study of pregnant patients at high risk for spontaneous preterm birth: patient's with history of spontaneous preterm birth, patient's with a short cervix and patient's symptomatic for preterm birth will be included. A control cohort of nulliparous patients without a short cervix will be recruited to provide baseline data. Plan to enroll 240 patients identified through our ultrasound unit with goal of 60 patients in each group.",[68,69],"Preterm Birth","Cervix; Pregnancy",[71,68,72],"Cervical Length","Inflammation","2025-06-27",{"date":75,"type":76},"2025-07-02","ACTUAL",{"date":78,"type":76},"2022-02-04",{"date":80,"type":64},"2026-06-01",{"name":23,"class":6},1]