About this trial
This prospective observational cohort study aims to investigate the impact of the maternal and early-life exposome on neonatal and early childhood health outcomes in twin pregnancies followed at University Hospital of Montpellier (France). Grounded in the Developmental Origins of Health and Disease (DOHaD) framework, the study focuses on how environmental, biological, and lifestyle exposures during pregnancy and the first year of life influence fetal growth, neonatal health, and early development.
A total of 120 women with monochorionic or dichorionic twin pregnancies and their 240 children will be included. Maternal exposome assessment includes air pollution exposure, lifestyle, diet, medical history, and biological measurements. Neonatal outcomes, including abnormal birth weight, will be evaluated at birth, and children will be followed until one year of age to assess growth, health events, and developmental outcomes. Biological samples collected at different times during the study will allow the assessment of chemical exposures and epigenetic markers. This study aims to generate original French twin pregnancy data and to improve understanding of environmental determinants of early-life health.
Eligibility criteria
Qualifiers
Patient of legal age (≥ 18 years)
Patient pregnant with a twin pregnancy ≥ 25 weeks of gestation
Pregnancy initially twin, triplet, or quadruplet, progressing to a twin pregnancy after spontaneous or medical embryo reduction, or after selective termination of pregnancy
Delivery planned at Montpellier University Hospital
Disqualifiers
Pregnant woman with at least one fetus presenting with a chromosomal or genetic abnormality or a polymalformative syndrome, and for whom early postnatal death is anticipated.
Planned travel preventing the study from being completed
Failure to obtain informed and written consent from the patient for participation in the study and the collection of biological samples
Patient unable to read and/or write French
Trial design
Treatments tested in this trial
- Biological samples from the mother
- Biological samples from the twins
Treatment groups
Locations
Sponsors and collaborators
University Hospital, Montpellier
Lead sponsor
Institut National de la Santé Et de la Recherche Médicale, France
Collaborator