Acute Aortic Syndrome (AAS)/Aortic Aneurysm is a common feature of aortic wall events, including aortic dissection, intramural hematoma, aortic ulceration and aortic trauma, and occurs in up to 35 cases per 100,000 cases per year between the ages of 65 and 75 years. Increased levels of the inflammatory biomarker high-sensitivity C-reactive protein predict cardiovascular events. Since statins lower levels of high-sensitivity C-reactive protein as well as cholesterol, the authors hypothesized that people with acute aortic syndrome but without hyperlipidemia might benefit from statin treatment.
(1) Patients with aortic dissection/ulceration/intermural hematoma/aortic aneurysm who underwent aortic arch replacement or endoluminal isolation or hybrid therapy;
(2) Paitents without clinically significant hyperlipidemia but with cardiovascular disease risk factors (such as male ≥45 years old, female ≥55 years old, hypertension, diabetes, chronic kidney disease, obesity, low HDL cholesterol, smoking, alcohol consumption, family history of early onset ischemic cardiovascular disease) and no previous use of statins;
(3) Patients are between 18 and 85 years old, male or female;
(4) Agree to participate in the study and sign the informed consent.
(1) Patients with allergy to statins;
(2) patients with active liver disease;
(3) patients with myopathy;
(4) Lactating women and pregnant women;
Nanjing Medical University
Lead sponsor
Beijing Anzhen Hospital
Collaborator
West China Hospital
Collaborator
The First Affiliated Hospital of Guangzhou Medical University
Collaborator
The Affiliated Hospital of Qingdao University Medical College
Collaborator