[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100424263":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":21,"locations":27,"responsibleParty":51,"collaborators":53,"id":57,"slug":10,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":10,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":64,"minAge":65,"maxAge":10,"enrollmentInfo":66,"targetDuration":10,"studyType":69,"phases":10,"briefSummary":70,"conditions":71,"keywords":74,"overallStatus":30,"whyStopped":10,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Guangzhou University of Traditional Chinese Medicine","OTHER",[8,12,15,18],{"label":9,"type":10,"description":11,"interventionNames":10},"Healthy control group",null,"aged ≥55 years old, no dementia, MCI or no family history of AD.",{"label":13,"type":10,"description":14,"interventionNames":10},"Alzheimer's disease high-risk group","aged ≥55 years old, immediate family members of AD patients",{"label":16,"type":10,"description":17,"interventionNames":10},"Alzheimer's disease group","aged ≥55 years old, diagnosed as AD patients",{"label":19,"type":10,"description":20,"interventionNames":10},"Mild cognitive impairment group","patients ≥55 years of age, diagnosed with MCI",[22],{"name":23,"role":24,"phone":25,"phoneExt":10,"email":26},"jianwen guo, Dr","CONTACT","13724899379","306247680@qq.com",[28],{"facility":29,"status":30,"city":31,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Guangdong Province Hospital of Tradtional Chinese Medicine","RECRUITING","Guangzhou","Guangdong","510120","China","CN",{"type":37,"coordinates":38},"Point",[39,40],113.25,23.11667,{"lat":40,"lon":39},[43,48],{"name":44,"role":24,"phone":45,"phoneExt":46,"email":47},"jianwen Guo, Dr","020-81887233","34530","jianwen_guo@msn.com",{"name":49,"role":50,"phone":10,"phoneExt":10,"email":10},"Jianwen Guo, MD","PRINCIPAL_INVESTIGATOR",{"type":52,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[54],{"name":55,"class":56},"Guangzhou Cadre Health Management Center","UNKNOWN","100424263",false,"NCT04804618","Proteomics Study of Mild Cognitive Impairment and Alzheimer's Disease","Exploring Research on Early Warning Indicators of Protein in Patients With Mild Cognitive Impairment and Alzheimer's Disease","Inclusion Criteria:\n\n1. Older than 55-year-old，male or female.\n2. patients meet the diagnosis of mild cognitive impairment (MCI) or Alzheimer's disease(AD) or whose family members were diagnoed with AD\n3. Complete self-rating scale for memory impairment (AD-8 scale)\n4. Those who agree to participate in clinical research and sign informed consent.\n\nExclusion Criteria:\n\n1. Patients with acute cardiovascular and cerebrovascular diseases, acute infections (pneumonia, urinary tract infection, oral infection, digestive tract infection), severe renal dysfunction, and uremia;\n2. Pregnant or lactating women;",true,"ALL","55 Years",{"count":67,"type":68},650,"ESTIMATED","OBSERVATIONAL","This study intends to adopt standardized and rigorous cross-sectional research, collect biological specimens (including blood, feces, urine, saliva and tongue coating) from eligible subjects, and use liquid chromatography\u002Fmass spectrometry (LC-MS\u002FMS) technology to explore early warning indicators of protein in patients with mild cognitive impairment and Alzheimer's disease",[72,73],"Alzheimer Disease, Early Onset","Protein; Disease",[75,76,77],"Alzheimer Disease","biomarker","protein","2022-11-14",{"date":80,"type":81},"2022-11-15","ACTUAL",{"date":83,"type":81},"2021-06-01",{"date":85,"type":68},"2026-06-30",{"name":5,"class":6},1]