[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100413522":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":25,"centralContacts":29,"locations":37,"responsibleParty":54,"collaborators":56,"id":59,"slug":11,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":11,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":11,"overallStatus":40,"whyStopped":11,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Guy's and St Thomas' NHS Foundation Trust","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"AF catheter ablation","ACTIVE_COMPARATOR",null,[13],"Procedure: AF catheter ablation",{"label":15,"type":10,"description":11,"interventionNames":16},"AV node ablation",[17],"Procedure: AV node ablation",[19,23],{"type":20,"name":9,"description":21,"armGroupLabels":22,"otherNames":11},"PROCEDURE","Isolation of all four pulmonary veins and additional lesions, considered indicated by the operator",[9],{"type":20,"name":15,"description":15,"armGroupLabels":24,"otherNames":11},[15],[26],{"name":27,"affiliation":5,"role":28},"Christopher A Rinaldi","PRINCIPAL_INVESTIGATOR",[30,34],{"name":27,"role":31,"phone":32,"phoneExt":11,"email":33},"CONTACT","02071889257","aldo.rinaldi@kcl.ac.uk",{"name":35,"role":31,"phone":32,"phoneExt":11,"email":36},"Felicity de Vere","felicity.de_vere@kcl.ac.uk",[38],{"facility":39,"status":40,"city":41,"state":11,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Guys and St Thomas' NHS Foundation Trust","RECRUITING","London","SE1 7EH","United Kingdom","UK",{"type":46,"coordinates":47},"Point",[48,49],-0.12574,51.50853,{"lat":49,"lon":48},[52,53],{"name":27,"role":31,"phone":32,"phoneExt":11,"email":33},{"name":35,"role":31,"phone":32,"phoneExt":11,"email":36},{"type":55,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR",[57],{"name":58,"class":6},"King's College London","100413522",false,"NCT04664686","Rate or Rhythm Control in CRT: the RHYTHMIC Study","RHYTHMIC","Inclusion Criteria:\n\n* Ability to provide informed consent to participate and willing to comply with the clinical investigation plan and follow-up schedule.\n* QRS duration \\>120ms on surface ECG, severe left ventricular systolic impairment (EF≤35%) and clinical symptoms of heart failure despite optimum medical therapy (NYHA class II-IV) at time of CRT implant or upgrade\n* Successful CRT implant or upgrade including atrial lead\n* Biventricular pacing percentage \\\u003C95% secondary to atrial fibrillation at least 3 months post implant or upgrade\n* Clinically indicated for AV node ablation\n\nExclusion Criteria:\n\n* Life expectancy \\\u003C1 year\n* Presence of atrial or ventricular thrombus\n* Permanent atrial fibrillation\n* Mechanical aortic valve replacement\n* Severe peripheral vascular disease\n* Female participants who are pregnant, lactating or planning pregnancy during the course of the study.\n* Participation in other studies with active treatment \u002F investigational arm","ALL","18 Years","85 Years",{"count":69,"type":70},70,"ESTIMATED","INTERVENTIONAL",[73],"NA","70 patients with heart failure, AF and CRT with BiV\\\u003C95% will be randomised to either AF ablation or AV node ablation. Evaluation at 6 months with echocardiography and clinical assessment.",[76,77],"Atrial Fibrillation","Heart Failure","2026-01-23",{"date":80,"type":81},"2026-01-26","ACTUAL",{"date":83,"type":81},"2021-10-19",{"date":85,"type":70},"2027-09-30",{"name":5,"class":6},1]