[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100634579":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":25,"locations":34,"responsibleParty":188,"collaborators":192,"id":206,"slug":10,"hasResults":207,"nctId":208,"briefTitle":209,"officialTitle":210,"acronym":211,"eligibilityCriteria":212,"healthyVolunteers":207,"sex":213,"minAge":10,"maxAge":10,"enrollmentInfo":214,"targetDuration":10,"studyType":217,"phases":10,"briefSummary":218,"conditions":219,"keywords":224,"overallStatus":37,"whyStopped":10,"lastUpdateSubmitDate":231,"lastUpdatePostDateStruct":232,"startDateStruct":235,"completionDateStruct":237,"leadSponsor":239,"locationsCount":240},{"fullName":5,"class":6},"Shanghai Chest Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"ⅡB-Ⅲ NSCLC following Neo-Chemo-IO & RATS sleeve lobectomy",null,"All patients in this cohort will receive neoadjuvant chemo-immunotherapy (Neo-Chemo-IO) first for clinical stage IIB-III non-small cell lung cancer ( NSCLC), followed by robot-assisted thoracoscopic surgery (RATS) sleeve lobectomy.",[13],"Procedure: Robot-assisted thoracoscopic surgery (RATS) sleeve lobectomy",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"PROCEDURE","Robot-assisted thoracoscopic surgery (RATS) sleeve lobectomy","After the neoadjuvant treatment reaches the expected effect (partial remission, complete remission, or stable disease), the patients will undergo RATS sleeve lobectomy.",[9],[21],{"name":22,"affiliation":23,"role":24},"Zhigang Li, MD, PhD","Shanghai Chest Hospital, Shanghai Jiao Tong University Medicine of School","STUDY_CHAIR",[26,30],{"name":22,"role":27,"phone":28,"phoneExt":10,"email":29},"CONTACT","0086-021-22200000","zhigang.li@shsmu.edu.cn",{"name":31,"role":27,"phone":32,"phoneExt":10,"email":33},"Lin Huang, MD, PhD","008618116061178","dr.huang.lin@shsmu.edu.cn",[35,54,69,83,98,113,127,139,155,169],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Fujian Medical University Union Hospital","RECRUITING","Fuzhou","Fujian","350001","China","CN",{"type":44,"coordinates":45},"Point",[46,47],119.30611,26.06139,{"lat":47,"lon":46},[50],{"name":51,"role":27,"phone":52,"phoneExt":10,"email":53},"Bin Zheng, MD, PhD","0086-0591-83357896","lacustrian@163.com",{"facility":55,"status":37,"city":56,"state":57,"zip":58,"country":41,"countryCode":42,"cosmosGeoPoint":59,"geoPoint":63,"contacts":64},"Guangdong Provincial People's Hospital","Guangzhou","Guangdong","510080",{"type":44,"coordinates":60},[61,62],113.25,23.11667,{"lat":62,"lon":61},[65],{"name":66,"role":27,"phone":67,"phoneExt":10,"email":68},"Wenzhao Zhong, MD, PhD","0086-020-83882222","13609777314@163.com",{"facility":70,"status":37,"city":71,"state":57,"zip":72,"country":41,"countryCode":42,"cosmosGeoPoint":73,"geoPoint":77,"contacts":78},"Shenzhen People's Hospital","Shenzhen","518020",{"type":44,"coordinates":74},[75,76],114.0683,22.54554,{"lat":76,"lon":75},[79],{"name":80,"role":27,"phone":81,"phoneExt":10,"email":82},"Guangsuo Wang, MD, PhD","0086-0755-25533018","908611104@qq.com",{"facility":84,"status":37,"city":85,"state":86,"zip":87,"country":41,"countryCode":42,"cosmosGeoPoint":88,"geoPoint":92,"contacts":93},"Jiangsu Cancer Institute & Hospital","Nanjing","Jiangsu","210009",{"type":44,"coordinates":89},[90,91],118.77778,32.06167,{"lat":91,"lon":90},[94],{"name":95,"role":27,"phone":96,"phoneExt":10,"email":97},"Ming Li, MD, PhD","0086-025-83283364","liming750523@163.com",{"facility":99,"status":37,"city":100,"state":101,"zip":102,"country":41,"countryCode":42,"cosmosGeoPoint":103,"geoPoint":107,"contacts":108},"The Affiliated Hospital of Qingdao University","Qingdao","Shandong","266000",{"type":44,"coordinates":104},[105,106],120.38042,36.06488,{"lat":106,"lon":105},[109],{"name":110,"role":27,"phone":111,"phoneExt":10,"email":112},"Wenjie Jiao, MD, PhD","0086-0532-96166","jiaowenjie@163.com",{"facility":114,"status":37,"city":115,"state":115,"zip":116,"country":41,"countryCode":42,"cosmosGeoPoint":117,"geoPoint":121,"contacts":122},"Tianjin Medical University Cancer Institute & Hospital","Tianjing","300060",{"type":44,"coordinates":118},[119,120],120.77196,31.46583,{"lat":120,"lon":119},[123],{"name":124,"role":27,"phone":125,"phoneExt":10,"email":126},"Jian You, MD, PhD","0086-022-23340123","youjiancn@126.com",{"facility":23,"status":37,"city":128,"state":10,"zip":129,"country":41,"countryCode":42,"cosmosGeoPoint":130,"geoPoint":134,"contacts":135},"Shanghai","200030",{"type":44,"coordinates":131},[132,133],121.45806,31.22222,{"lat":133,"lon":132},[136,137],{"name":22,"role":27,"phone":28,"phoneExt":10,"email":29},{"name":31,"role":27,"phone":138,"phoneExt":10,"email":10},"0086-18116061178",{"facility":140,"status":37,"city":141,"state":10,"zip":142,"country":143,"countryCode":144,"cosmosGeoPoint":145,"geoPoint":149,"contacts":150},"Hôpital Saint Joseph Marseille","Marseille","13001","France","FR",{"type":44,"coordinates":146},[147,148],5.38107,43.29695,{"lat":148,"lon":147},[151],{"name":152,"role":27,"phone":153,"phoneExt":10,"email":154},"Ilies Bouabdallah, MD, PhD","+33 (0)4 91 80 65 00","ibouabdallah@hopital-saint-joseph.fr",{"facility":156,"status":37,"city":157,"state":10,"zip":158,"country":143,"countryCode":144,"cosmosGeoPoint":159,"geoPoint":163,"contacts":164},"University Hospital, Rouen","Rouen","76000",{"type":44,"coordinates":160},[161,162],1.09932,49.44313,{"lat":162,"lon":161},[165],{"name":166,"role":27,"phone":167,"phoneExt":10,"email":168},"Jean-Marc Baste, MD, PhD","+33 (0)2 32 88 89 90","jean-marc.baste@chu-rouen.fr",{"facility":170,"status":37,"city":171,"state":10,"zip":172,"country":173,"countryCode":174,"cosmosGeoPoint":175,"geoPoint":179,"contacts":180},"Azienda Ospedaliera di Cosenza","Cosenza","87100","Italy","IT",{"type":44,"coordinates":176},[177,178],16.25307,39.2989,{"lat":178,"lon":177},[181,185],{"name":182,"role":27,"phone":183,"phoneExt":10,"email":184},"Ralph Schmid, MD, PhD","+39 0984 6811","ralph_a_schmid@hotmail.com",{"name":186,"role":27,"phone":183,"phoneExt":10,"email":187},"Franca Melfi, MD, PhD","franca.melfi@unical.it",{"type":189,"investigatorFullName":190,"investigatorTitle":191,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Zhigang Li","Professor, MD, PhD",[193,194,195,196,198,199,200,201,204],{"name":99,"class":6},{"name":36,"class":6},{"name":55,"class":6},{"name":197,"class":6},"Tianjin Medical University Cancer Institute and Hospital",{"name":84,"class":6},{"name":70,"class":6},{"name":156,"class":6},{"name":202,"class":203},"Hopital Saint Joseph Marseille","UNKNOWN",{"name":205,"class":6},"Azienda Ospedaliera Cosenza","100634579",false,"NCT07541521","RATS Sleeve Lobectomy After Neo-Chemo-IO for NSCLC","Robotic-Assisted Sleeve Lobectomy for Non-Small Cell Lung Cancer After Neoadjuvant Chemoimmunotherapy","RIDDLE-NSCLC","Inclusion Criteria:\n\n* Age ≥18 years\n* ECOG performance status 0-2\n* Histologically confirmed NSCLC\n* AJCC 9th clinical stage IIB-III, M0, deemed resectable or potentially resectable by the multidisciplinary tumour discussion (MDT)\n* Planned neoadjuvant chemo-immunotherapy (PD-1\u002FPD-L1 inhibitor + platinum doublet；additional neoadjuvant thoracic radiotherapy is allowed)\n* Planned curative-intent RATS sleeve lobectomy with systematic nodal dissection\n* Baseline and restaging imaging per protocol (CT ± PET-CT)\n* Complete 30-day postoperative follow-up\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Metastatic disease (M1) at baseline or on restaging.\n* No immunotherapy component in neoadjuvant regimen (pure chemotherapy) .\n* Prior systemic therapy or thoracic radiotherapy for the current cancer before starting chemo-IO.\n* Palliative intent or planned non-anatomic resection only (e.g., wedge) when sleeve\u002Flobectomy is indicated oncologically.\n* Clear unresectability at restaging (e.g., multistation bulky N2\u002FN3 not responding; unreconstructable T4 invasion) or MDT consensus against surgery.\n* Contraindication to general anesthesia or prohibitive cardiopulmonary risk precluding sleeve\u002Flobectomy.\n* Active autoimmune disease requiring systemic immunosuppression within 2 years, prior organ transplant, or history of grade ≥2 pneumonitis\u002FILD\n* Uncontrolled infection, pregnancy or breastfeeding, or any intercurrent illness that would compromise participation.","ALL",{"count":215,"type":216},100,"ESTIMATED","OBSERVATIONAL","The goal of this multicenter prospective observational study is to learn about the surgical difficulty and outcomes of robotic-assisted sleeve lobectomy in patients with non-small cell lung cancer (NSCLC) after neoadjuvant chemoimmunotherapy. The main questions it aims to answer are:\n\nWhat is the rate of unsuccessful robotic-assisted sleeve lobectomy after neoadjuvant chemoimmunotherapy?\n\nWhat factors are associated with unsuccessful surgery?\n\nHow do surgeons subjectively assess intraoperative difficulty across multiple dimensions during these procedures?\n\nIn this study, unsuccessful surgery is defined as any of the following: conversion to thoracotomy, incomplete (non-R0) resection, or major postoperative complications. Participants who are scheduled to undergo curative-intent robotic-assisted sleeve lobectomy as part of their routine clinical care after neoadjuvant chemoimmunotherapy will be enrolled from multiple centers. Clinical, intraoperative, pathological, and short-term postoperative data will be collected prospectively. In addition, surgeons will be asked to provide a multidimensional subjective assessment of intraoperative difficulty, including factors such as pleural adhesions, hilar fibrosis, nodal matting, fissure completeness, and vascular inflammation or edema, to better characterize the technical challenges of surgery and their association with perioperative outcomes.",[220,221,222,223],"Stage IIB-III NSCLC","Sleeve Lobectomy","Robotic Surgery","Neoadjuvant Chemoimmunotherapy",[225,226,227,228,229,230],"stage IIB-III NSCLC","sleeve lobectomy","robotic surgery","neoadjuvant chemoimmunotherapy","perioperative outcomes","difficulty of surgery","2026-04-16",{"date":233,"type":234},"2026-04-21","ACTUAL",{"date":236,"type":216},"2026-04-13",{"date":238,"type":216},"2027-05-30",{"name":5,"class":6},10]