About this trial
Investigators established the efficacy evaluation criteria for tumor markers (RecistTM) in the preliminary research. Among patients with advanced non-small cell lung cancer, patients with positive driving genes are more likely to exhibit abnormalities in tumor markers, which suggests that this criteria may be more suitable for evaluating the efficacy of targeted therapy in driving gene positive patients. Moreover, The judgment rules of the prelimary criteria still need further improvement. Therefore, in order to broaden the application scope of the RecistTM criteria, further improve the evaluation rules of RecistTM criteria, and multi-dimensionally confirm the reliability of RecistTM criteria on efficacy evaluation, investigators plan to conduct research on the application of RecistTM criteria in evaluating the efficacy of targeted therapy for advanced non-small cell lung cancer with positive driving genes.
Eligibility criteria
Qualifiers
NSCLC patients with stage IIIB-IV
Driver gene positive (EGFR,ALK,C-MET, ROS,RET, HER2);
First line targeted therapy.
Performance status of 0-2 on the ECOG criteria.
Disqualifiers
Patients with dysphagia;
Unable to taking medication on time;
Patients with a history of abuse of psychotropic substances who are unable to quit or have mental disorders
Trial design
Treatments tested in this trial
- RecistTM criteria
Treatment groups
Sponsors and collaborators
Xueqin Yang
Lead sponsor
Third Military Medical University
Sponsor institution