[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100514357":3},{"organization":4,"armGroups":7,"interventions":31,"overallOfficials":55,"centralContacts":59,"locations":67,"responsibleParty":88,"collaborators":90,"id":100,"slug":37,"hasResults":101,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":37,"eligibilityCriteria":105,"healthyVolunteers":106,"sex":107,"minAge":108,"maxAge":109,"enrollmentInfo":110,"targetDuration":37,"studyType":113,"phases":114,"briefSummary":116,"conditions":117,"keywords":121,"overallStatus":70,"whyStopped":37,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":138},{"fullName":5,"class":6},"Medical University of South Carolina","OTHER",[8,14,21,27],{"label":9,"type":6,"description":10,"interventionNames":11},"Healthy Participants (Study 1)","Healthy adult participants with no history of psychiatric or neurological illness who undergo mechanistic and modeling procedures, including multimodal neuroimaging, behavioral cognitive tasks, and non-therapeutic neurostimulation, to characterize brain networks underlying cognitive flexibility and emotion regulation.",[12,13],"Device: Single-Pulse Transcranial Magnetic Stimulation","Behavioral: Cognitive Flexibility and Emotion Regulation Tasks",{"label":15,"type":16,"description":17,"interventionNames":18},"Depressed Participants - EEG-Synchronized rTMS (Studies 2 and 3)","EXPERIMENTAL","Participants with major depressive disorder who receive individualized, EEG-synchronized repetitive transcranial magnetic stimulation (rTMS), delivered alone or in combination with cognitive tasks and\u002For brief cognitive behavioral therapy (CBT), to modulate neural networks underlying cognitive flexibility and emotion regulation.",[12,19,20,13],"Device: EEG-Synchronized Repetitive Transcranial Magnetic Stimulation (rTMS)","Behavioral: Cognitive Behavioral Therapy (CBT)",{"label":22,"type":23,"description":24,"interventionNames":25},"Depressed Participants - Non-Synchronized rTMS Comparator","ACTIVE_COMPARATOR","Participants with major depressive disorder who receive repetitive transcranial magnetic stimulation delivered using standard stimulation parameters without EEG phase synchronization, serving as a comparator condition.",[12,13,26],"Device: Non-Synchronized Repetitive Transcranial Magnetic Stimulation",{"label":28,"type":16,"description":29,"interventionNames":30},"Depressed Participants - Cognitive Behavioral Therapy Only (Study 4)","Participants with major depressive disorder who receive a course of cognitive behavioral therapy (CBT) along with MRI and behavioral assessments, without transcranial magnetic stimulation or EEG-based neurostimulation. This group allows evaluation of behavioral intervention effects independent of neurostimulation.",[20,13],[32,38,42,47,51],{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":37},"DEVICE","Single-Pulse Transcranial Magnetic Stimulation","Single-pulse transcranial magnetic stimulation delivered during EEG or neuroimaging sessions for non-therapeutic mapping of cortical excitability and functional connectivity.",[15,22,9],null,{"type":33,"name":39,"description":40,"armGroupLabels":41,"otherNames":37},"EEG-Synchronized Repetitive Transcranial Magnetic Stimulation (rTMS)","Repetitive transcranial magnetic stimulation delivered using individualized, EEG-derived stimulation parameters designed to synchronize stimulation timing with participants' alpha oscillatory phase. This closed-loop approach is intended to modulate neural networks underlying cognitive flexibility and emotion regulation. Stimulation may be delivered in accelerated sessions across multiple days.",[15],{"type":43,"name":44,"description":45,"armGroupLabels":46,"otherNames":37},"BEHAVIORAL","Cognitive Behavioral Therapy (CBT)","A structured, brief cognitive behavioral therapy program targeting depression and related symptoms, including cognitive restructuring, emotion regulation, and coping skill development, delivered in an accelerated format during the study period.",[28,15],{"type":43,"name":48,"description":49,"armGroupLabels":50,"otherNames":37},"Cognitive Flexibility and Emotion Regulation Tasks","Behavioral tasks designed to engage and assess cognitive flexibility and emotion regulation processes, performed during or adjacent to neurostimulation sessions or as part of study assessments.",[28,15,22,9],{"type":33,"name":52,"description":53,"armGroupLabels":54,"otherNames":37},"Non-Synchronized Repetitive Transcranial Magnetic Stimulation","Repetitive transcranial magnetic stimulation delivered using standard stimulation parameters without EEG phase synchronization, serving as a comparator condition.",[22],[56],{"name":57,"affiliation":5,"role":58},"Lisa McTeague, PhD","PRINCIPAL_INVESTIGATOR",[60,64],{"name":57,"role":61,"phone":62,"phoneExt":37,"email":63},"CONTACT","843-792-8274","MCTEAGUE@MUSC.EDU",{"name":65,"role":61,"phone":37,"phoneExt":37,"email":66},"Christina Marsicano","recovers@musc.edu",[68],{"facility":69,"status":70,"city":71,"state":72,"zip":73,"country":74,"countryCode":75,"cosmosGeoPoint":76,"geoPoint":81,"contacts":82},"Medical Univeristy of South Carolina","RECRUITING","Charleston","South Carolina","29425","United States","US",{"type":77,"coordinates":78},"Point",[79,80],-79.93275,32.77632,{"lat":80,"lon":79},[83,86],{"name":84,"role":61,"phone":62,"phoneExt":37,"email":85},"Lisa M McTeague, PhD","mcteague@musc.edu",{"name":65,"role":61,"phone":37,"phoneExt":37,"email":87},"chm275@musc.edu",{"type":89,"investigatorFullName":37,"investigatorTitle":37,"investigatorAffiliation":37,"oldNameTitle":37,"oldOrganization":37},"SPONSOR",[91,93,95,98],{"name":92,"class":6},"Columbia University",{"name":94,"class":6},"University of Oklahoma",{"name":96,"class":97},"Defense Advanced Research Projects Agency","FED",{"name":99,"class":6},"University of Wisconsin, Madison","100514357",false,"NCT05977439","RECOVERS - Realigning Emotion and COgnition Via prEcision Regulation networkS","A Multiphase Program of Multimodal Computational Modeling and Hybrid Interventions Including EEG-Synchronized Transcranial Magnetic Stimulation and Cognitive Behavioral Therapy","Study 1 (Healthy Participants)\n\nInclusion Criteria:\n\n* Age 18-65 years\n* Medically and psychiatrically healthy with no history of psychiatric or neurological disorders\n* English-speaking\n* Capacity to provide informed consent\n* Willingness and ability to complete study procedures\n* Negative pregnancy test for participants of childbearing potential\n\nExclusion Criteria:\n\n* Any current or past psychiatric diagnosis\n* Neurological disorders or history of central nervous system disease\n* History of seizure or epilepsy or use of medications that lower seizure threshold\n* Significant head injury or loss of consciousness\n* Implanted metal or contraindications to MRI or TMS\n* Substance use disorder (excluding nicotine or caffeine)\n* Pregnancy or plans to become pregnant during study participation\n* Inability to complete study procedures\n\nStudies 2, 3, and 4 (Participants with Depression)\n\nInclusion Criteria:\n\n* Age 18-65 years\n* Current diagnosis of Major Depressive Disorder (MDD)\n* Depression severity consistent with study criteria (e.g., HAM-D ≥ 17)\n* No history of psychotic or bipolar disorders\n* English-speaking\n* Capacity to provide informed consent\n* Willingness and ability to complete study procedures\n* Negative pregnancy test for participants of childbearing potential\n\nExclusion Criteria:\n\n* Neurological disorders or history of central nervous system disease\n* History of seizure or epilepsy or use of medications that lower seizure threshold\n* Significant head injury or loss of consciousness\n* Implanted metal or contraindications to MRI or TMS\n* Substance use disorder (excluding nicotine or caffeine)\n* Current participation in another interventional clinical trial\n* Pregnancy or plans to become pregnant during study participation\n* Any condition that would interfere with safe participation or completion of study procedures",true,"ALL","18 Years","65 Years",{"count":111,"type":112},120,"ESTIMATED","INTERVENTIONAL",[115],"NA","In this research study, investigators examine how brain activity changes during tests of emotional processing, attention, and memory using multimodal neuroimaging methods including electroencephalography (EEG), functional magnetic resonance imaging (fMRI), and functional near-infrared spectroscopy (fNIRS). Transcranial magnetic stimulation (TMS) is used to probe and modulate brain networks related to cognitive flexibility and emotion regulation.\n\nThe study includes multiple related sub-studies involving healthy participants and participants with depression. Some study components focus on mechanistic modeling using non-therapeutic neurostimulation in healthy participants, while other components include interventional approaches such as individualized EEG-synchronized repetitive TMS (rTMS), cognitive tasks, and brief cognitive behavioral therapy (CBT) in participants with depression. Certain study components also evaluate CBT alone without TMS to assess behavioral intervention effects.",[118,119,120],"Depression","Major Depressive Disorder","Suicidal Ideation",[122,123,124,125,126,127,128],"transcranial magnetic stimulation","EEG-synchronized rTMS","closed-loop neurostimulation","depression","suicide prevention","cognitive behavioral therapy (CBT)","neuroplasticity","2026-06-12",{"date":131,"type":132},"2026-06-16","ACTUAL",{"date":134,"type":132},"2024-02-01",{"date":136,"type":112},"2028-10-01",{"name":5,"class":6},1]