[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100621192":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":12,"centralContacts":25,"locations":31,"responsibleParty":43,"collaborators":12,"id":47,"slug":12,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":12,"eligibilityCriteria":51,"healthyVolunteers":48,"sex":52,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":12,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":69,"overallStatus":77,"whyStopped":12,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Hopital La Rabta","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Outside Ramadan fasting","NO_INTERVENTION","Patients with PAI treated with prednisolone 5mg\u002Fday, outside Ramadan fasting",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Ramadan fasting","EXPERIMENTAL","Patients with PAI treated with prednisolone 5mg\u002Fday during Ramadan fasting.",[18],"Other: Ramadan fasting",[20],{"type":6,"name":14,"description":21,"armGroupLabels":22,"otherNames":23},"Ramadan fasting is a religious dry intermittent fasting",[14],[24],"dry intermittent fasting",[26],{"name":27,"role":28,"phone":29,"phoneExt":12,"email":30},"Melika Chihaoui, Professor","CONTACT","+216 98647327","melika.chihaoui@fmt.utm.tn",[32],{"facility":33,"status":12,"city":34,"state":12,"zip":12,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":12},"University Hospital La Rabta","Tunis","Tunisia","TN",{"type":38,"coordinates":39},"Point",[40,41],10.16579,36.81897,{"lat":41,"lon":40},{"type":44,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"PRINCIPAL_INVESTIGATOR","Melika Chihaoui","Professor of Endocrinology, Faculty of Medicine of Tunis, University Tunis El Manar. Head of the Department of Endocrinology, University hospital La rabta, Tunis, Tunisia.","100621192",false,"NCT07367425","Risks of Ramadan Fasting in Patients With Primary Adrenal Insufficiency Treated With Prednisolone.","Inclusion Criteria:\n\n* subjects with primary adrenal insufficiency known for at least one year, treated with a glucocorticoid and a mineralocorticoid, who wish to fast during Ramadan 2026.\n\nExclusion Criteria:\n\n* presence of diabetes, renal, hepatic, cardiac, or respiratory insufficiency; use of hypoglycemic agents (sulfonylureas), diuretics, use of any glucocorticoid other than the prescribed replacement therapy; poor disease control (asthenia, malaise, hyperpigmentation, discontinuation of treatment, etc.); pregnancy; breastfeeding; menstruation.","ALL","20 Years","70 Years",{"count":56,"type":57},35,"ESTIMATED","INTERVENTIONAL",[60],"NA","In primary adrenal insufficiency (PAI), there is a risk of hypoglycemia and dehydration. These risks seem to be increased during intermittent fasting. A previous study in patients with PAI treated with hydrocortisone at a dose of 20 mg\u002Fday showed that the prevalence of hypoglycemia was as high outside (63%) as during Ramadan fasting (71%), and that there was no risk of dehydration. We propose to evaluate the risk of complications during and outside of Ramadan fasting through a prospective study with subjects taken as their own controls, in 35 patients with PAI treated with prednisolone at a dose of 5 mg\u002Fday. Patients will undergo an interview, physical examination, blood sampling, and continuous glucose monitoring (CGM) during two weeks of fasting and two weeks of non-fasting.",[63,64,65,66,67,68],"Primary Adrenal Insufficiency","Ramadan Fasting","Prednisolone","Continuous Glucose Monitoring","Hypoglycemia Non-Diabetic","Dehydration",[70,14,71,72,73,74,75,76],"primary adrenal insufficiency","continuous glucose monitoring","hypoglycemia","dehydration","glucocorticoid replacement therapy","prednisolone","hypotension","NOT_YET_RECRUITING","2026-01-16",{"date":80,"type":81},"2026-01-26","ACTUAL",{"date":83,"type":57},"2026-01-22",{"date":85,"type":57},"2026-03-30",{"name":5,"class":6},1]