[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100635731":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":18,"centralContacts":10,"locations":23,"responsibleParty":42,"collaborators":44,"id":47,"slug":10,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":10,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":53,"minAge":54,"maxAge":10,"enrollmentInfo":55,"targetDuration":58,"studyType":59,"phases":10,"briefSummary":60,"conditions":61,"keywords":10,"overallStatus":26,"whyStopped":10,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":73},{"fullName":5,"class":6},"Weill Cornell Medical College in Qatar","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Groupe 1: T2D and no established cardiovascular complications",null,"* HbA1C level ≥ 6.5% and a fasting glucose level ≥126 mg\u002Fdl (7.0 mmol\u002Fl)\n* No concomitant cardiovascular complications (coronary artery disease, stroke, nephropathy, retinopathy, peripheral arterial disease) per the history, medical records and biochemistry.",{"label":13,"type":10,"description":14,"interventionNames":10},"Groupe 2: T2D and established coronary artery disease","* The presence of coronary artery disease (CAD) confirmed by coronary angiogram prior to the inclusion.\n* Patients with concomitant microvascular complications of diabetes will be excluded (nephropathy, retinopathy).",{"label":16,"type":10,"description":17,"interventionNames":10},"Groupe 3: Control, no T2D","* Fasting glycemia \\\u003C100 mg\u002Fdl and HbA1C \\\u003C5.7%\n* Absence of a concomitant cardiovascular disease (CAD, stroke, PAD, neuropathy)",[19],{"name":20,"affiliation":21,"role":22},"Charbel Abi Khalil, MD,PhD","Weill Cornell Medicine-Qatar","PRINCIPAL_INVESTIGATOR",[24],{"facility":25,"status":26,"city":27,"state":10,"zip":10,"country":28,"countryCode":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":36},"Hamad Medical Corporation","RECRUITING","Doha","Qatar","QA",{"type":31,"coordinates":32},"Point",[33,34],51.53096,25.28545,{"lat":34,"lon":33},[37],{"name":38,"role":39,"phone":40,"phoneExt":10,"email":41},"Jassim Al Suwaidi, MD","CONTACT","+974 4439 5354","jalsuwaidi@hamad.qa",{"type":43,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[45],{"name":25,"class":46},"INDUSTRY","100635731",false,"NCT07556497","Role of Endothelial Progenitor Cells Dysregulation and Inflammation in the Pathophysiology of Cardiovascular Complications of Type 2 Diabetes","Inclusion Criteria:\n\n* T2D\n* Males and females\n* Older than 18 years of age\n* Willingness to participate in the study and provide written consent form\n* Consent to having peripheral blood withdrawals and urine collection for the study requirement.\n\nExclusion Criteria:\n\n* Unable to meet the inclusion criteria\n* Type I diabetes, MODY diabetes or other form of diabetes\n* Active infection, inflammation, cancer or acute illness of any kind (other than a cardiovascular complication of diabetes if applicable in the group they are assigned to).\n* Chronic inflammation (eg. auto-immune diseases) or infections (eg. HIV, chronic hepatitis).\n* Evidence of malignancy within the past 5 years",true,"ALL","18 Years",{"count":56,"type":57},90,"ESTIMATED","6 Months","OBSERVATIONAL","This study aims to isolate endothelial progenitor cells (EPCs) from participants with type 2 diabetes (T2D) and cardiovascular complications and to comprehensively characterize EPC dysfunction. Specifically, the study will evaluate maladaptive angiocrine signaling, calcium signaling pathways, and the role of inflammation in EPC function and the progression of atherosclerosis during T2D development. A sub-study will assess EPC functionality by examining endothelial nitric oxide synthase (eNOS) expression and activity, as well as the effectiveness of in vitro eNOS gene enhancement.",[62,63],"Diabete Type 2","Cardio Vascular Disease","2026-04-21",{"date":66,"type":67},"2026-04-29","ACTUAL",{"date":69,"type":67},"2020-11-17",{"date":71,"type":57},"2026-12-31",{"name":5,"class":6},1]