Role of Microvascular Insulin Resistance and Cardiorespiratory Fitness Diabetes
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age30-55
SponsorUniversity of Colorado, Denver
About this trial
The goal of this two-site grant proposal is to determine the role of the decreased insulin-mediated muscle perfusion found in type 2 diabetes in contributing to the development of cardiac and skeletal muscle dysfunction and subsequent functional exercise impairment. In addition, it is also our goal to determine whether exercise training attenuates insulin resistance and restores insulin-mediated perfusion to the heart and to skeletal muscle, leading to improved cardiac function and exercise performance.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Sedentary (defined as less than 1 hour per week of physical activity)
BMI: 25-40
Men and women with and without type 2 diabetes
Disqualifiers
Documented cardiovascular disease
Uncontrolled hypertension: disease systolic blood pressure (SBP) > 150, diastolic blood pressure (DBP)> 110
Obstructive pulmonary disease or asthma
Peripheral neuropathy
Trial design
Design model
Parallel
Treatments tested in this trial
Cardiovascular exercise
Behavioral15 weeks of cardiovascular exercise 3x/week for 50 minutes/session
Treatment groups
150 Participants
are divided into 2 treatment groupsGroup A: Type 2 DiabetesExperimental treatment 1 intervention
Group B: Healthy overweight controlExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Change in peak oxygen consumption (VO2)
Subjects' peak oxygen consumption will be tested on a stationary bike before and after 15 weeks of exercise
Time frame
Through study completion, approximately 4 months2
Change in insulin sensitivity
The investigators will evaluate the changes in insulin sensitivity utilizing a euglycemic insulin clamp
Time frame
Through study completion, approximately 4 monthsSponsors and contacts
Click on the lead sponsor to view all of their trials.
University of Colorado, Denver
Lead sponsor
University of Virginia
Collaborator
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborator
Source ClinicalTrials.gov