[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100469730":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":11,"centralContacts":16,"locations":25,"responsibleParty":39,"collaborators":7,"id":42,"slug":7,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":7,"eligibilityCriteria":46,"healthyVolunteers":43,"sex":47,"minAge":48,"maxAge":7,"enrollmentInfo":49,"targetDuration":7,"studyType":52,"phases":7,"briefSummary":53,"conditions":54,"keywords":59,"overallStatus":27,"whyStopped":7,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":70},{"fullName":5,"class":6},"Abramson Cancer Center at Penn Medicine","OTHER",null,[9],{"type":6,"name":10,"description":10,"armGroupLabels":7,"otherNames":7},"Collection of personal health information from women treated at the University of Pennsylvania under an approved HIPAA waiver.",[12],{"name":13,"affiliation":14,"role":15},"Jennifer Zhang, MD","Abramson Cancer Center","PRINCIPAL_INVESTIGATOR",[17,22],{"name":18,"role":19,"phone":20,"phoneExt":7,"email":21},"Julia T. Lewandowski","CONTACT","215-662-2861","Julia.Lewandowski@Pennmedicine.upenn.edu",{"name":13,"role":19,"phone":23,"phoneExt":7,"email":24},"215-615-6810","Jennifer.Zhang@Pennmedicine.upenn.edu",[26],{"facility":14,"status":27,"city":28,"state":29,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":7},"RECRUITING","Philadelphia","Pennsylvania","19104","United States","US",{"type":34,"coordinates":35},"Point",[36,37],-75.16362,39.95238,{"lat":37,"lon":36},{"type":15,"investigatorFullName":40,"investigatorTitle":41,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"Jennifer Zhang","Assistant Professor of Surgery","100469730",false,"NCT05396612","Role of the Immune Environment in Response to Therapy in Breast Cancer","Inclusion criteria:\n\nWomen 18 years of age or older with non-metastatic breast cancer undergoing surgical resection in the University of Pennsylvania Health System.\n\nExclusion criteria:\n\nMales Children Pregnant individuals","FEMALE","18 Years",{"count":50,"type":51},300,"ESTIMATED","OBSERVATIONAL","This is an observational case-control study of tissues collected from women with ER+HER2- breast cancers. The immune environments of these cancers will be compared to triple negative and HER2+ breast cancers. No randomization or changes to standard of care treatment will occur as part of the study.",[55,56,57,58],"Breast Cancer","ER Positive Breast Cancer","HER2-negative Breast Cancer","TNBC - Triple-Negative Breast Cancer",[60],"Immune microenvironment","2025-07-02",{"date":63,"type":64},"2025-07-08","ACTUAL",{"date":66,"type":64},"2022-10-03",{"date":68,"type":51},"2032-12-31",{"name":5,"class":6},1]