Background:
The Laboratory of Immune System Biology (LISB) works with other labs at the National Institutes of Health. They study how parts of living things come together to make a whole. LISB designs and improves research tests on human samples like blood and cells. In order to do its work, LISB needs to have a lot of these samples available.
Objective:
To collect biological specimens to use for designing and improving research tests. Specimens include blood, stool, saliva, and skin/mucosal swabs.
Eligibility:
Healthy people ages 3-80
Design:
Participants will be screened with an interview about their general health and their medical history. They will have a physical exam and blood tests.
If the results of the screening are normal, participants will be asked to give one or more of these samples:
Blood will be drawn from an arm vein with a needle and syringe.
Mucus and skin will be collected by rubbing the area with a cotton swab. The areas may include the top of the tongue, inside the cheek, nostrils, behind the ear, elbow pit, or vagina.
Participants will spit into a tube to collect saliva.
Participants will pass stool into a plastic container that fits in the toilet under the seat. They will get sampling kits and instructions.
Over the next 5 years, if more samples are needed, participants will be contacted to set up another visit to the NIH. These visits will each take about 1 hour.
About every 2 years, when participants come to NIH for a visit, extra blood will be collected. It will be tested for HIV and hepatitis B and C.
...
Aged 3-80 years.
Able to provide informed consent (for ages >=18 years) or has a parent or guardian who can provide informed consent on their behalf (for ages <18 years).
Agree to allow biological samples to be stored for future research.
Willing to provide blood, stool, saliva, skin/mucosal/tonsil swabs, and/or skin punch biopsy specimens.
Pregnancy.
History of autoimmune or autoinflammatory disease.
Diabetes mellitus.
Cancer chemotherapy within the past 5 years.