[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100400261":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":13,"locations":19,"responsibleParty":37,"collaborators":7,"id":40,"slug":7,"hasResults":41,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":41,"sex":47,"minAge":48,"maxAge":7,"enrollmentInfo":49,"targetDuration":7,"studyType":52,"phases":7,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":22,"whyStopped":7,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":69},{"fullName":5,"class":6},"Aarhus University Hospital","OTHER",null,[9],{"name":10,"affiliation":11,"role":12},"Louise B Callesen","Experimental Clinical Oncology","PRINCIPAL_INVESTIGATOR",[14],{"name":15,"role":16,"phone":17,"phoneExt":7,"email":18},"Louise B Callesen, MD","CONTACT","+4578462535","louicall@rm.dk",[20],{"facility":21,"status":22,"city":23,"state":24,"zip":25,"country":26,"countryCode":27,"cosmosGeoPoint":28,"geoPoint":33,"contacts":34},"Department of Oncology, Aarhus University Hospital","RECRUITING","Aarhus N","Danmark","8200","Denmark","DK",{"type":29,"coordinates":30},"Point",[31,32],10.17317,56.20367,{"lat":32,"lon":31},[35],{"name":15,"role":16,"phone":36,"phoneExt":7,"email":18},"30482884",{"type":12,"investigatorFullName":38,"investigatorTitle":39,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"Louise Bach Callesen","Principal Investigator","100400261",false,"NCT04491929","Selective Internal Radiation Therapy With 90Y Resin Micropheres for Refractory Colorectal Cancer Liver Metastases","Selective Internal Radiation Therapy With 90Y Resin Micropheres for Refractory Colorectal Cancer Liver Metastases - SIRT - A Translational Feasibility Study","SIRT","Inclusion Criteria:\n\n* Diagnosis of metastatic colorectal adenocarcinoma with liver dominant disease\n* Diagnosis of liver metastasis may be made by histo- or cyto-pathology, or by clinical and imaging criteria.\n* The Liver metastasis are not eligible for resection, RFA or SBRT\n* All patients must be off all chemotherapeutic regimens for 14 days prior to SIRT treatment\n* All patients must be off vascular endothelial growth factor inhibitors for 6 weeks prior to SIRT treatment\n* Progressive disease, severe intolerance during or following all standard lines of chemo-therapy\n* Eastern Cooperative Oncology Group (ECOG) performance status of 0-1\n* Age 18 years or older\n* Able to understand written information\n* Consent to samples for translational research\n\nExclusion Criteria:\n\n* Pretherapeutic work-up procedure with Tc-99m macroaggregated albumin (MAA) scintigraphy showing extrahepatic foci in GI-tract\n* Evidence of any detectable Tc-99m macroaggregated albumin deposition in the stomach or duodenum, after application of established angiographic techniques to stop such deposition\n* Previous radiation therapy to the lungs and\u002For to the upper abdomen overlapping with dose to the liver at interventionist´s decision\n* Lung shunt greater than 20% or \\> 30 Gray radiation absorbed dose to the lungs, at estimated by Tc-99m-MAA\n* Pregnancy\n* Symptomatic lung disease precluding SIRT at interventionist´s decision\n* Active uncontrolled infection\n* Any pre-treatment laboratory findings within 30 days of treatment demonstrating: alanine aminotransferase level greater than 5 times upper normal limit and\u002For serum bilirubin greater than 2 mg\u002Fdl (\\>34 umol\u002Fl)\n* Current or previously evidence of ascites on CT-scan or physical examination\n* Tumour volume greater than 50% of liver volume\n* Conditions precluding translational samples","ALL","18 Years",{"count":50,"type":51},30,"ESTIMATED","OBSERVATIONAL","Observational, feasibility study investigating biological aspects in patients with liver metastasis from colorectal cancer undergoing treatment with SIRT, by translational analysis of biological samples.",[55],"Liver Metastasis Colon Cancer",[57,58,59],"Liver metastasis Colon Cancer","Circulating Tumour DNA","Selective Internal Radiation Therapy","2026-01-12",{"date":62,"type":63},"2026-01-13","ACTUAL",{"date":65,"type":63},"2020-11-01",{"date":67,"type":51},"2028-09-30",{"name":5,"class":6},1]