[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100558207":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":25,"centralContacts":30,"locations":35,"responsibleParty":51,"collaborators":53,"id":60,"slug":24,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":24,"eligibilityCriteria":65,"healthyVolunteers":66,"sex":67,"minAge":68,"maxAge":24,"enrollmentInfo":69,"targetDuration":24,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":24,"overallStatus":78,"whyStopped":24,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"VA Office of Research and Development","FED",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Standard TMS","ACTIVE_COMPARATOR","A series of standard TMS protocols will be delivered to determine target engagement compared to seTMS. TMS will be delivered using neuro-navigation based on participant's own MRI images. Intensity will be set to 120% of the participant's motor threshold. Participants will be monitored during the session for adverse events and\u002For side effects.",[13],"Device: TMS",{"label":15,"type":10,"description":16,"interventionNames":17},"Sensory-entrained TMS (seTMS)","Sensory entrained TMS (seTMS) is a combination of music and TMS to align brain oscillations and enhance the effects of TMS. seTMS will be delivered to determine target engagement to noninvasive seTMS brain stimulation compared to standard TMS. TMS will be delivered using neuro-navigation based on participant's own MRI images. Intensity will be set to 120% of the participant's motor threshold. Participants will be monitored during the session for adverse events and\u002For side effects.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DEVICE","TMS","transcranial magnetic brain stimulation",[15,9],null,[26],{"name":27,"affiliation":28,"role":29},"Jessica M Ross, PhD","VA Palo Alto Health Care System, Palo Alto, CA","PRINCIPAL_INVESTIGATOR",[31],{"name":27,"role":32,"phone":33,"phoneExt":24,"email":34},"CONTACT","(530) 902-2450","jessica.ross1@va.gov",[36],{"facility":28,"status":24,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Palo Alto","California","94304-1207","United States","US",{"type":43,"coordinates":44},"Point",[45,46],-122.14302,37.44188,{"lat":46,"lon":45},[49,50],{"name":27,"role":32,"phone":33,"phoneExt":24,"email":34},{"name":27,"role":29,"phone":24,"phoneExt":24,"email":24},{"type":52,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR",[54,57],{"name":55,"class":56},"National Institute of Mental Health (NIMH)","NIH",{"name":58,"class":59},"Stanford University","OTHER","100558207",false,"NCT06548113","Sensory Synchronized Imaging and Neuromodulation","Investigation of Sensory Synchronized Human Brain Imaging and Neuromodulation","Inclusion Criteria:\n\n* Men and women, ages 18 years and up\n* English speaking\n* Military Veterans\n\nExclusion Criteria:\n\n* Those with a contraindication for MRIs (e.g. implanted metal)\n* History of head trauma with loss of consciousness\n* History of seizures or on medications that substantially reduce seizure threshold\n* Neurological or uncontrolled medical disease\n* Active substance abuse\n* Currently pregnant or breastfeeding",true,"ALL","18 Years",{"count":70,"type":71},250,"ESTIMATED","INTERVENTIONAL",[74],"NA","The purpose of this research study is to better understand the relationship between the type of brain stimulation used and how it changes brain activity in adult military Veterans. The goal is to use this understanding to develop new, personalized brain stimulation. The investigators evaluate brain changes from different types of transcranial magnetic brain stimulation (TMS).",[77],"Major Depressive Disorder","NOT_YET_RECRUITING","2026-06-22",{"date":81,"type":82},"2026-06-25","ACTUAL",{"date":84,"type":71},"2026-07-13",{"date":86,"type":71},"2030-12-31",{"name":5,"class":6},1]