Health TrialsbyHealthPanel

Sex Differences in E-Cigarette Perception

ConditionsNicotine DependenceE-cigarette Use
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age21-44
SponsorYale University

About this trial

This study examines differences between males and females in the appeal and addiction potential of menthol flavored e-cigarettes with and without nicotine.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Able to read/write in English

Current cigarette smoking

Prior e-cigarette exposure

Biochemically verified cigarette use

Disqualifiers

Significant medical concerns that would increase study risk

Use of psychoactive drugs unless prescribed and stable

Allergy to menthol or other e-liquid ingredients

Dislike of menthol

Trial design

Design model

Crossover

Treatments tested in this trial

  • Nicotine Level 1 (0mg/ml)

    Other intervention

    Menthol with be paired with 0mg/ml nicotine in an e-cigarette

  • Nicotine Level 2 (36mg/ml)

    Other intervention

    Menthol with be paired with 36mg/ml nicotine in an e-cigarette

  • Nicotine Level 3 (59mg/ml)

    Other intervention

    Menthol with be paired with 59mg/ml nicotine in an e-cigarette

Treatment groups

60 Participants
are divided into 2 treatment groups
Group A: Sampling Session - Lab 1Experimental treatment 3 interventions
Group B: Concurrent Choice Session- Lab 2Experimental treatment 2 interventions

Trial outcomes

Primary outcomes

1

Proportion of Choices

Differences in proportion of choices for the two menthol e-cigarette for males and females in the Lab 2 preference task

Time frame
For the 3 hour period of the Lab 2 preference task
2

Breakpoint

Difference in highest point of the progressive ratio schedule obtained between males and females

Time frame
During the 3 hour period of the Lab 2 preference task

Secondary outcomes

1

Reward

Difference in scores (range: 0-100) of the Liking/Wanting Subscale of the Drug Effects Questionnaire

Time frame
Immediately (~2 minutes) after e-cigarette exposures in Lab 1

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Yale University

Lead sponsor

National Institute on Drug Abuse (NIDA)

Collaborator

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: