Short-term Fat Overfeeding on the Effects of Liver Metabolism
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorUniversity of Oxford
About this trial
Despite work showing the overconsumption of saturated fatty acids (SFA) to be metabolically deleterious, debate continues about whether there is a link between SFA and cardiovascular disease risk. To explore this, we are undertaking a human in vivo parallel-design study, comparing two isocaloric high-fat diets; one enriched with SFA and the other enriched with unsaturated fatty acids (UFAs), to determine the impact of dietary fat composition on postprandial metabolism, liver fat, cardiac fat and cardiac function.
Eligibility criteria
Qualifiers
The participant is willing and able to give informed consent for participation in the study.
Male or Female, aged ≥18 or ≤65 years.
Body Mass Index ≥19 ≤35 kg/m2
No medical condition or relevant drug therapy that is known to affect liver or adipose tissue metabolism.
Disqualifiers
The participant is unwilling or unable to give informed consent for participation in the study. - Aged ≤18 or ≥65 years
Body Mass Index ≤19 or ≥35kg/m2
Blood haemoglobin <135mg/dL for men and <120mg/dL for women
Donated (or lost) ≥250 ml of blood in the previous two months.
Trial design
Treatments tested in this trial
- Diet
Treatment groups
26 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov