[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100463582":3},{"organization":4,"armGroups":7,"interventions":29,"overallOfficials":44,"centralContacts":48,"locations":53,"responsibleParty":84,"collaborators":86,"id":90,"slug":34,"hasResults":91,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":95,"eligibilityCriteria":96,"healthyVolunteers":97,"sex":98,"minAge":99,"maxAge":100,"enrollmentInfo":101,"targetDuration":34,"studyType":104,"phases":105,"briefSummary":107,"conditions":108,"keywords":111,"overallStatus":56,"whyStopped":34,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":126},{"fullName":5,"class":6},"University of North Carolina, Chapel Hill","OTHER",[8,14,19,24],{"label":9,"type":10,"description":11,"interventionNames":12},"One 5-Minute Walking Bout Each Hour","ACTIVE_COMPARATOR","A 4-hour sedentary behavior bout, during which the participant remains seated while watching a non-stimulatory documentary.\n\nThe interruption strategy includes breaking up the 4-hour sitting bout with one 5-minute light intensity walking bout each hour. Each participant will be re-randomized to any of the non-completed arms after completion of the initial 4-hour sitting bout and interruption strategy until all arms have been completed.",[13],"Behavioral: One 5-Minute Walking Bout Each Hour",{"label":15,"type":10,"description":16,"interventionNames":17},"One 15-Minute Standing Bout Each Hour","A 4-hour sedentary behavior bout, during which the participant remains seated while watching a non-stimulatory documentary.\n\nThe interruption strategy includes breaking up the 4-hour sitting bout with one 15-minute standing bout each hour. Each participant will be re-randomized to any of the non-completed arms after completion of the initial 4-hour sitting bout and interruption strategy until all arms have been completed.",[18],"Behavioral: One 15-Minute Standing Bout Each Hour",{"label":20,"type":10,"description":21,"interventionNames":22},"One 5-Minute Walking Bout and One 15-Minute Standing Bout Each Hour","A 4-hour sedentary behavior bout, during which the participant remains seated while watching a non-stimulatory documentary.\n\nThe interruption strategy includes breaking up the 4-hour sitting bout with one 5-minute light intensity walking bout and one 15-minute standing bout each hour. Each participant will be re-randomized to any of the non-completed arms after completion of the initial 4-hour sitting bout and interruption strategy until all arms have been completed.",[23],"Behavioral: One 5-Minute Walking Bout and One 15-Minute Standing Bout Each Hour",{"label":25,"type":10,"description":26,"interventionNames":27},"Uninterrupted Sitting","A 4-hour sedentary behavior bout, during which the participant remains seated while watching a non-stimulatory documentary.\n\nThis uninterrupted sedentary bout will serve as a control. Each participant will be re-randomized to any of the non-completed arms after completion of the initial 4-hour sitting bout and interruption strategy until all arms have been completed.",[28],"Behavioral: Uninterrupted Sitting",[30,35,38,41],{"type":31,"name":9,"description":32,"armGroupLabels":33,"otherNames":34},"BEHAVIORAL","One 5-minute light intensity walking break per hour throughout the 4-hour SB condition",[9],null,{"type":31,"name":15,"description":36,"armGroupLabels":37,"otherNames":34},"One 15-minute standing break per hour throughout the 4-hour SB condition",[15],{"type":31,"name":20,"description":39,"armGroupLabels":40,"otherNames":34},"Two breaks per hour throughout the 4-hour SB condition, alternating between a 5-minute light intensity walking break and a 15-minute standing break",[20],{"type":31,"name":25,"description":42,"armGroupLabels":43,"otherNames":34},"No breaks will be provided throughout the 4-hour SB condition. This will be used as the control condition",[25],[45],{"name":46,"affiliation":5,"role":47},"Erik Hanson, PhD","PRINCIPAL_INVESTIGATOR",[49],{"name":46,"role":50,"phone":51,"phoneExt":34,"email":52},"CONTACT","9199620816","switchstudy@unc.edu",[54],{"facility":55,"status":56,"city":57,"state":58,"zip":59,"country":60,"countryCode":61,"cosmosGeoPoint":62,"geoPoint":67,"contacts":68},"University of North Carolina at Chapel Hill","RECRUITING","Chapel Hill","North Carolina","27599","United States","US",{"type":63,"coordinates":64},"Point",[65,66],-79.05584,35.9132,{"lat":66,"lon":65},[69,71,73,76,78,80,82],{"name":46,"role":50,"phone":70,"phoneExt":34,"email":52},"919-962-0816",{"name":72,"role":47,"phone":34,"phoneExt":34,"email":34},"Erik D Hanson, PhD",{"name":74,"role":75,"phone":34,"phoneExt":34,"email":34},"Gaurav J Dave, DrPH","SUB_INVESTIGATOR",{"name":77,"role":75,"phone":34,"phoneExt":34,"email":34},"Michelle Meyer, PhD",{"name":79,"role":75,"phone":34,"phoneExt":34,"email":34},"Feng-Chang Lin, PhD",{"name":81,"role":75,"phone":34,"phoneExt":34,"email":34},"Bethany Barone Gibbs, PhD",{"name":83,"role":75,"phone":34,"phoneExt":34,"email":34},"Maihan Vu, DrPH",{"type":85,"investigatorFullName":34,"investigatorTitle":34,"investigatorAffiliation":34,"oldNameTitle":34,"oldOrganization":34},"SPONSOR",[87],{"name":88,"class":89},"National Heart, Lung, and Blood Institute (NHLBI)","NIH","100463582",false,"NCT05316571","Sitting Interruption and Whole-body Cardiovascular Health","Sitting Interruption and Whole-body Cardiovascular Health: Linking Physiological Responses to Risk Behaviors","SWITCH","Inclusion Criteria:\n\n* Aged between 30-60 years\n* Insufficiently active: self-reported exercise \\\u003C90 minutes per week for the past 3 months\n* Sedentary: self-reported sitting \\>8 hours per day\n* Self-reported ability to walk 4 blocks and climb 2 flights of stairs\n* Possession of cellular phone able to receive text messages\n\nExclusion Criteria:\n\n* Use of assisted-walking devices\n* Comorbid condition that would limit the ability to reduce sedentary behavior (e.g., musculoskeletal condition, current chemotherapy)\n* Plans for major surgery within next 3 months\n* Recent history (\\\u003C1 year) of ischemic heart disease, chronic heart failure, stroke, or chronic kidney disease\n* Recent (\\\u003C 1 year) or planned bariatric surgery\n* Systolic blood pressure ≥160 mmHg or diastolic blood pressure ≥100 mmHg\n* Current or recent (within last 6 months) pregnancy; current or recent (within last 3 months) breastfeeding\n* Morbidly obesity (BMI \\>40 kg\u002Fm\\^2) or underweight (BMI \\\u003C18.5 kg\u002Fm\\^2)\n* Use of anti-hypertensive drugs\n* Use of glucose-controlling medication\n* Heavy alcohol consumption (\\>15 drinks per week)",true,"ALL","30 Years","60 Years",{"count":102,"type":103},56,"ESTIMATED","INTERVENTIONAL",[106],"NA","There is strong evidence for the association between sedentary behaviors and cardiovascular diseases such as coronary heart disease and stroke. However, the public currently has no clear guidance on how to limit or interrupt their sedentary behaviors. This study will identify and test the physiological effects of several sedentary behavior interruption strategies and explore the feasibility (i.e., likelihood of an individual performing the requested activities) of those strategies to inform the development of public policy surrounding sedentary behavior interruption. Long-term, the findings of this study will inform a large clinical trial that can test whether sedentary behavior reduction can decrease cardiovascular disease risk.",[109,110],"Sedentary Behavior","Sedentary Time",[109,112,113,114,115,116],"Interruption","Sitting","Cardiovascular","Arterial Stiffness","Pulse Wave Velocity","2026-03-13",{"date":119,"type":120},"2026-03-16","ACTUAL",{"date":122,"type":120},"2022-08-15",{"date":124,"type":103},"2026-05-31",{"name":5,"class":6},1]