[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100579447":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":25,"centralContacts":29,"locations":35,"responsibleParty":51,"collaborators":54,"id":60,"slug":24,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":24,"eligibilityCriteria":65,"healthyVolunteers":66,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":24,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":80,"overallStatus":37,"whyStopped":24,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Stanford University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active TMS, Sham TMS","EXPERIMENTAL","Participants will receive 2 sessions of Transcranial Magnetic Stimulation (TMS) delivered using standard intermittent theta-burst (iTBS) parameters (600 pulses, 3 min, 120% rMT). Participants will receive, on separate sessions, either active or sham iTBS delivered during wakefulness and\u002For NREM sleep stages while recording with Electroencephalography (EEG). Participants will perform the N-back task and Multi-source Interference Task (MSIT) during each session to measure working memory and cognitive control performance.",[13],"Device: TMS",{"label":15,"type":10,"description":16,"interventionNames":17},"Sham TMS, Active TMS","Participants will receive 2 sessions of Transcranial Magnetic Stimulation (TMS) delivered during using standard intermittent theta-burst (iTBS) parameters (600 pulses, 3 min, 120% rMT). Participants will receive, on separate sessions, either active or sham iTBS delivered during wakefulness and\u002For NREM sleep stages while recording with Electroencephalography (EEG). Participants will perform the N-back task and Multi-source Interference Task (MSIT) during each session to measure working memory and cognitive control performance.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DEVICE","TMS","Transcranial magnetic stimulation (TMS) applies magnetic pulses to stimulate nerve cells in the brain.",[9,15],null,[26],{"name":27,"affiliation":5,"role":28},"Umair Hassan, PhD","PRINCIPAL_INVESTIGATOR",[30],{"name":31,"role":32,"phone":33,"phoneExt":24,"email":34},"Hansong Lee, MS","CONTACT","408-909-2203","kellerlab@stanford.edu",[36],{"facility":5,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"RECRUITING","Stanford","California","94305","United States","US",{"type":44,"coordinates":45},"Point",[46,47],-122.16608,37.42411,{"lat":47,"lon":46},[50],{"name":31,"role":32,"phone":33,"phoneExt":24,"email":34},{"type":28,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Umair Hassan","Postdoctoral Researcher in Department of Psychiatry and Behavioral Sciences",[55,58],{"name":56,"class":57},"National Center for Advancing Translational Sciences (NCATS)","NIH",{"name":59,"class":57},"National Institute of Mental Health (NIMH)","100579447",false,"NCT06824415","Sleep TMS for Depression","Optimizing Depression Treatment Through Sleep-state Brain Stimulation","Inclusion Criteria:\n\n* Adults ages 18-65 years\n* Current Major Depressive Disorder (MDD) diagnosis\n* Failed ≥1 antidepressant medication\n* Moderate-to-severe depression\n* Stable antidepressant medication dose for ≥ 6 weeks prior to enrollment\n* Healthy control participants are adults ages 18-65 years without current MDD symptoms, not taking antidepressant or antipsychotic medications, and without major psychiatric, neurological, substance use, medical conditions affecting brain function, or TMS\u002FMRI contraindications.\n\nExclusion Criteria:\n\n* Intellectual disability\n* Significant head injury\u002Fneurological disorder\n* Pregnancy or postpartum\n* TMS\u002FMRI contraindications\n* Active substance use\u002Fsuicidal ideation",true,"ALL","18 Years","65 Years",{"count":71,"type":72},55,"ESTIMATED","INTERVENTIONAL",[75],"NA","The goal of this study is to establish the feasibility, tolerability, and preliminary efficacy of sleep-state transcranial magnetic stimulation (TMS) for enhancing plasticity in depression treatment.",[78,79],"Major Depression","Sleep",[81,82,83,84,85,86,87,88,89],"sleep","tms","eeg","iTBS","real-time","closed-loop","NREM","sleep spindle","slow oscillations","2026-06-18",{"date":92,"type":93},"2026-06-23","ACTUAL",{"date":95,"type":93},"2025-05-01",{"date":97,"type":72},"2028-05-30",{"name":5,"class":6},1]