[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100625865":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":28,"centralContacts":32,"locations":41,"responsibleParty":62,"collaborators":64,"id":67,"slug":24,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":70,"acronym":24,"eligibilityCriteria":71,"healthyVolunteers":68,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":24,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":44,"whyStopped":24,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"University of Colorado, Denver","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Snack Type 1: Walnuts","EXPERIMENTAL","Participants will complete a 12 week diet intervention, during which they will be asked to reduce their daily caloric intake. During the diet intervention, participants in the Snack Type 1 group will be asked to eat a daily snack of walnuts, which will be provided by the study team. Participants will meet with study staff on a weekly basis during the intervention (with some meetings virtual and in-person visits every 2-3 weeks).",[13],"Other: Snack Type 1: Walnuts",{"label":15,"type":16,"description":17,"interventionNames":18},"Snack Type 2: Pretzels","ACTIVE_COMPARATOR","Participants will complete a 12 week diet intervention, during which they will be asked to reduce their daily caloric intake. During the diet intervention, participants in the Snack Type 2 group will be asked to eat a daily snack of pretzels, which will be provided by the study team. Participants will meet with study staff on a weekly basis during the intervention (with some meetings virtual and in-person visits every 2-3 weeks).",[19],"Other: Snack Type 2: Pretzels",[21,25],{"type":6,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"Participants will complete a 12 week diet intervention, during which they will be asked to reduce their daily caloric intake. During the diet intervention, participants in the Snack Type 1 group will be asked to eat a daily snack of walnuts, which will be provided by the study team.",[9],null,{"type":6,"name":15,"description":26,"armGroupLabels":27,"otherNames":24},"Participants will complete a 12 week diet intervention, during which they will be asked to reduce their daily caloric intake. During the diet intervention, participants in the Snack Type 2 group will be asked to eat a daily snack of pretzels, which will be provided by the study team.",[15],[29],{"name":30,"affiliation":5,"role":31},"Kristina T Legget, PhD","PRINCIPAL_INVESTIGATOR",[33,38],{"name":34,"role":35,"phone":36,"phoneExt":24,"email":37},"Allison Hild, BS","CONTACT","3037249024","allison.hild@cuanschutz.edu",{"name":30,"role":35,"phone":39,"phoneExt":24,"email":40},"303-724-5809","kristina.legget@cuanschutz.edu",[42],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"University of Colorado Anschutz Medical Campus","RECRUITING","Aurora","Colorado","80045","United States","US",{"type":51,"coordinates":52},"Point",[53,54],-104.83192,39.72943,{"lat":54,"lon":53},[57,59,61],{"name":58,"role":35,"phone":39,"phoneExt":24,"email":40},"Kristina Legget, PhD",{"name":34,"role":35,"phone":60,"phoneExt":24,"email":37},"303-724-9024",{"name":30,"role":31,"phone":24,"phoneExt":24,"email":24},{"type":63,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR",[65],{"name":66,"class":6},"California Walnut Commission","100625865",false,"NCT07428187","Snacking Effects on the Brain Response to Foods and Satiety During Dieting","Inclusion Criteria:\n\n* 25-45 years old\n* BMI at least 27 kg\u002Fm2\n* Comfortable completing a weight-loss intervention\\\\\n* Willing to consume a daily snack of either walnuts or pretzels\n\nExclusion Criteria:\n\n* Nut or wheat allergy\n* History of bariatric surgery\n* Current eating disorder\n* Current illicit substance use\n* Current pregnancy, lactation (or less than 3 months after stopping lactation), or less than 6 months postpartum\n* Uncontrolled hypertension (\\>160\u002F100 mmHg)\n* Significant endocrine\u002Fmetabolic disease kidney disease, liver disease, or blood disease that would be anticipated to affect study results\n* Taking injectable medications, sulfonylureas, or meglitinides for diabetes treatment\n* Taking weight-loss medications, or steroids within \\~3 months prior to study participation (e.g., GLP-1 receptor agonists)\n* Significant mental health changes within \\~3 months prior to study participation (e.g., medication adjustments, new psychiatric diagnoses, hospitalization relating to mental health concerns)\n* Neurological illnesses or injury that would be anticipated to affect MRI data\n* Weight change greater than 10% within 3 months prior to study participation\n* Currently participating in another weight-loss study\n* Not comfortable eating the study-provided meals (with allowances for dietary preferences) and\u002For following a highly restrictive diet (e.g., vegan)\n* MRI-specific exclusion criteria (e.g., metal in the body, weight \\>500 lbs","ALL","25 Years","45 Years",{"count":76,"type":77},70,"ESTIMATED","INTERVENTIONAL",[80],"NA","This study plans to learn more about how different types of snacks may affect brain processes relating to eating behaviors during a diet intervention.",[83],"Overweight\u002FObesity",[85,86,87,88,89,90,91,92,93,94],"Dieting","Weight loss","Overweight","Obesity","Food","Neuroimaging","Body weight","Eating","Brain","Magnetic resonance imaging","2026-03-19",{"date":97,"type":98},"2026-03-23","ACTUAL",{"date":100,"type":98},"2026-03-05",{"date":102,"type":77},"2028-03-31",{"name":5,"class":6},1]