About this trial
The goal of this observational study is to learn if an artificial intelligence (AI)-based speech analysis tool can identify which patients with memory problems need specialist evaluation at a memory clinic. The main questions it aims to answer are:
Can the AI model accurately distinguish between patients who need referral to a memory clinic (those with dementia or Mild Cognitive Impairment) and patients who don't (those with normal cognition or memory problems from other causes like depression)? Which speech patterns and cognitive test features are most useful for making this distinction?
Researchers will compare speech recordings and cognitive test results from patients diagnosed with dementia or MCI to those from patients with normal cognition or non-neurodegenerative cognitive impairment to see if the AI model can reliably predict who needs specialist dementia care.
Participants will:
Complete standard cognitive tests at the memory clinic Perform structured speech tasks while being audio-recorded Receive their usual clinical evaluation and diagnosis from memory clinic specialists
The results of this study will help develop a tool that can assist doctors in making faster, more accurate decisions about which patients need specialist dementia evaluation, potentially leading to earlier diagnosis and better patient outcomes.
Eligibility criteria
Qualifiers
Age > 50 years
Fluent in Danish
Minimum of 7 years of schooling
A diagnosis of either MCI or AD, given at the SUH memory clinic within 6 months before enrollment
Disqualifiers
Significantly impaired vision or hearing (to the extent that the patient cannot participate in the AI analysis)
MMSE score < 16
Concomitant diagnoses which are expected to influence cognitive impairment (eg. depression)
Patients unable to give consent
Trial design
Treatments tested in this trial
- Mini-mental State Examination
- Addenbrooke's Cognitive Examination
- Speech Task - Picture Description
- Speech Task - Picture Recall
- MRI
- blood sampling
- Depression screening
- Somatic- and neurological examination
- Speech Task - Picture Narrative
Treatment groups
Sponsors and collaborators
Zealand University Hospital
Lead sponsor
DemensAI ApS (private tech partner, Denmark)
Collaborator