[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100594014":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":11,"centralContacts":20,"locations":30,"responsibleParty":69,"collaborators":11,"id":71,"slug":11,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":72,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":11,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":92,"overallStatus":33,"whyStopped":11,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Medtronic Vascular","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Renal nerve stimulation performed prior to and post renal artery denervation (RDN)","EXPERIMENTAL",null,[13],"Device: Renal nerve stimulation",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":11},"DEVICE","Renal nerve stimulation","Renal nerve stimulation will be performed prior to and post renal denervation.",[9],[21,26],{"name":22,"role":23,"phone":24,"phoneExt":11,"email":25},"Sjors Wijnands","CONTACT","+31 6 1113 5502","sjors.wijnands@medtronic.com",{"name":27,"role":23,"phone":28,"phoneExt":11,"email":29},"Marianne Wanten","+31 613703414","marianne.wanten@medtronic.com",[31,51],{"facility":32,"status":33,"city":34,"state":11,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Hippokration General Hospital of Athens","RECRUITING","Athens","11527","Greece","GR",{"type":39,"coordinates":40},"Point",[41,42],23.72784,37.98376,{"lat":42,"lon":41},[45,49],{"name":46,"role":23,"phone":47,"phoneExt":11,"email":48},"Konstantinos Tsioufis, MD","00302132088025","ktsioufis@gmail.com",{"name":46,"role":50,"phone":11,"phoneExt":11,"email":11},"PRINCIPAL_INVESTIGATOR",{"facility":52,"status":33,"city":53,"state":11,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":61,"contacts":62},"University Hospital Galway","Galway","H91 YR71","Ireland","IE",{"type":39,"coordinates":58},[59,60],-9.05095,53.27245,{"lat":60,"lon":59},[63,67],{"name":64,"role":23,"phone":65,"phoneExt":11,"email":66},"Eileen Coen","+353 86 145 5568","eileen.coen@nuigalway.ie",{"name":68,"role":50,"phone":11,"phoneExt":11,"email":11},"Faisal Sharif, MD",{"type":70,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100594014",false,"NCT07013929","Spyral InSight Study","Spyral InSight Early Clinical Feasibility Study","Spyral InSight","Inclusion Criteria:\n\n1. 20 - 70 years of age\n2. Office SBP ≥150 mmHg and \\\u003C180 mmHg and DBP ≥90 mmHg\n3. Individual is prescribed with one, two, or three antihypertensive medication classes\n4. 24-hour ABPM average of SBP ≥135 and \\\u003C170 mmHg at Baseline\n\nExclusion Criteria:\n\n1. Prior renal denervation.\n2. Individual lacks appropriate renal artery Anatomy\n3. Has a renal artery stent\n4. Individual has an estimated glomerular filtration rate (eGFR) of \\\u003C60 mL\u002Fmin\u002F1.73m2\n5. Individual is taking SGLT2 inhibitors or GLP-1 agonists\n6. Individual requires chronic oxygen support or mechanical ventilation\n7. Primary pulmonary hypertension.\n8. Secondary cause of hypertension\n9. Pregnant, nursing or planning to become pregnant during the study.\n10. Individual has a documented condition that would prohibit or interfere with ability to obtain an accurate blood pressure measurement\n11. Individual is currently taking anti-mineralocorticoid drugs.","ALL","20 Years","70 Years",{"count":82,"type":83},19,"ESTIMATED","INTERVENTIONAL",[86],"NA","The purpose of the Spyral InSight Early Clinical Feasibility Study is to characterize the physiological response to renal nerve stimulation (RNS) in humans prior to and post renal denervation.",[89,90,91],"Hypertension","Vascular Diseases","Cardiovascular Diseases",[89,91,90,93,94],"Denervation","Renal Denervation","2026-04-30",{"date":97,"type":98},"2026-05-04","ACTUAL",{"date":100,"type":98},"2025-06-09",{"date":102,"type":83},"2027-07-01",{"name":5,"class":6},2]