[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100470454":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":26,"centralContacts":30,"locations":38,"responsibleParty":73,"collaborators":75,"id":78,"slug":25,"hasResults":79,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":79,"sex":85,"minAge":86,"maxAge":25,"enrollmentInfo":87,"targetDuration":25,"studyType":90,"phases":91,"briefSummary":93,"conditions":94,"keywords":25,"overallStatus":41,"whyStopped":25,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Kantonsspital Winterthur KSW","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"SBRT with 9 Gy x 3 fractions to the treatment site.","EXPERIMENTAL","Patients will be treated with SBRT delivering 9 Gy x 3 fractions (BED10: 51.3 Gy) to the treatment site.",[13],"Radiation: SBRT",{"label":15,"type":16,"description":17,"interventionNames":18},"SBRT with 7 Gy x 5 fractions to the treatment site","ACTIVE_COMPARATOR","Patients will be treated with SBRT delivering 7 Gy x 5 fractions (BED10: 59.5 Gy) to the treatment site.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"RADIATION","SBRT","Stereotactic multiple fraction radiotherapy",[15,9],null,[27],{"name":28,"affiliation":5,"role":29},"Robert Foerster, MD","PRINCIPAL_INVESTIGATOR",[31,35],{"name":28,"role":32,"phone":33,"phoneExt":25,"email":34},"CONTACT","+4152 266 21 21","robert.foerster@ksw.ch",{"name":36,"role":32,"phone":33,"phoneExt":25,"email":37},"Nidar Batifi, RN","nidar.batifi@ksw.ch",[39,61],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Kantonsspital Winterthur","RECRUITING","Winterthur","Canton of Zurich","8401","Switzerland","CH",{"type":48,"coordinates":49},"Point",[50,51],8.72413,47.50564,{"lat":51,"lon":50},[54,55,57,58],{"name":28,"role":32,"phone":33,"phoneExt":25,"email":34},{"name":36,"role":32,"phone":56,"phoneExt":25,"email":37},"+41052 266 21 21",{"name":28,"role":29,"phone":25,"phoneExt":25,"email":25},{"name":59,"role":60,"phone":25,"phoneExt":25,"email":25},"Christina Schroeder, MD","SUB_INVESTIGATOR",{"facility":62,"status":41,"city":63,"state":25,"zip":64,"country":45,"countryCode":46,"cosmosGeoPoint":65,"geoPoint":69,"contacts":70},"University Hospital Bern","Bern","3010",{"type":48,"coordinates":66},[67,68],7.44744,46.94809,{"lat":68,"lon":67},[71],{"name":72,"role":32,"phone":25,"phoneExt":25,"email":25},"Hossein Hemmatazad, MD",{"type":74,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[76],{"name":77,"class":6},"Krebsforschung Schweiz, Bern, Switzerland","100470454",false,"NCT05406063","Stereotactic Multiple Fraction Radiotherapy for Non-spine Bone Metastases","Stereotactic Multiple Fraction Radiotherapy for Non-spine Bone Metastases a Multicentre Prospective, Open Label, Randomised Controlled Phase 3 Non-inferiority Clinical Trial","SMILE","Inclusion Criteria:\n\n* Personally signed and dated written informed consent,\n* Histological diagnosis of malignancy,\n* Histologically or radiologically diagnosed bone metastasis,\n* Age ≥ 18 years\n* Pain or under pain control medication\n\nExclusion Criteria:\n\n* Pregnant or lactating women,\n* Women of childbearing potential or sexually active males not willing to use effective contraception while on treatment and 3 months after the end of treatment,\n* Inability to follow the procedures of the study, e.g., due to language problems, psychological disorders, dementia, etc.,\n* Prior radiotherapy to the intended treatment site,\n* Lesions \\> 5cm in maximum diameter,\n* Prior treatment with radioactive isotopes within 30 days of randomisation,\n* Spinal column, hands, feet, or head as intended treatment site,- Fracture at the intended treatment site,\n* Surgery required or previous surgery at the intended treatment site\n* Instability of the intended treatment site.","ALL","18 Years",{"count":88,"type":89},162,"ESTIMATED","INTERVENTIONAL",[92],"NA","To investigate, whether multi-fraction stereotactic body radiation therapy (SBRT) within 3 treatment fractions is non-inferior to the current standard of care of 5 fraction SBRT regarding pain response at 3 months after radiotherapy.",[95,96,97],"Radiation Therapy","Bone Metastases","Pain","2025-05-19",{"date":100,"type":101},"2025-05-22","ACTUAL",{"date":103,"type":101},"2022-06-01",{"date":105,"type":89},"2026-05-31",{"name":5,"class":6},2]