[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100607461":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":10,"locations":10,"responsibleParty":13,"collaborators":17,"id":21,"slug":10,"hasResults":22,"nctId":23,"briefTitle":24,"officialTitle":24,"acronym":10,"eligibilityCriteria":25,"healthyVolunteers":22,"sex":26,"minAge":27,"maxAge":28,"enrollmentInfo":29,"targetDuration":10,"studyType":32,"phases":10,"briefSummary":33,"conditions":34,"keywords":38,"overallStatus":42,"whyStopped":10,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":10},{"fullName":5,"class":6},"Hubei Cancer Hospital","OTHER",[8,11],{"label":9,"type":10,"description":9,"interventionNames":10},"immunotherapy group with opioids",null,{"label":12,"type":10,"description":12,"interventionNames":10},"immunotherapy group without opioids",{"type":14,"investigatorFullName":15,"investigatorTitle":16,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Yu Qian","Doctor",[18],{"name":19,"class":20},"Cancer Hospital Chinese Academy of Medical Science","UNKNOWN","100607461",false,"NCT07188857","Study on the Relationship Between Opioid Drugs and the Therapeutic Efficacy of Immunotherapy","Inclusion Criteria:\n\n* Aged ≥ 18 years; Histologically confirmed advanced NSCLC (Stage IIIb-IV); Need to receive ICIs treatment; Accompanied by moderate or severe pain (NRS score ≥ 4); Need to use opioid drugs for pain management; Able to understand and sign the informed consent form.\n\nExclusion Criteria:\n\n* Suffering from severe dysfunction of important organs such as heart, liver, and kidney; Suffering from mental illness or receiving treatment with psychotropic drugs; Pregnant or lactating women; Participating in other clinical trials; Allergic to opioid drugs.","ALL","18 Years","80 Years",{"count":30,"type":31},100,"ESTIMATED","OBSERVATIONAL","Relationship between pain and the efficacy of immunotherapy: Does the degree of pain control affect the therapeutic efficacy of ICIs? Does the use of opioid drugs independently affect the efficacy of immunotherapy?",[35,36,37],"Pain Management","Immune Checkpoint Inhibitor","Opioid",[39,40,41],"pain management","opioids","immune checkpoint inhibitor","NOT_YET_RECRUITING","2025-09-16",{"date":45,"type":46},"2025-09-23","ACTUAL",{"date":48,"type":31},"2025-09-17",{"date":50,"type":31},"2027-10-01",{"name":5,"class":6}]