[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100603888":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":45,"centralContacts":50,"locations":58,"responsibleParty":71,"collaborators":73,"id":76,"slug":41,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":41,"eligibilityCriteria":81,"healthyVolunteers":77,"sex":82,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":41,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":95,"overallStatus":97,"whyStopped":41,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Rush University Medical Center","OTHER",[8,15,21],{"label":9,"type":10,"description":11,"interventionNames":12},"Two Synovial Fluid Withdrawals","ACTIVE_COMPARATOR","Subjects randomized to Arm 1 will have 2 synovial fluid withdrawals; one at the preoperative clinic visit and one at the time of surgery",[13,14],"Procedure: Synovial Fluid withdrawal at the preoperative clinic visit","Procedure: Synovial fluid withdrawal at the time of surgery",{"label":16,"type":17,"description":18,"interventionNames":19},"Platelet-Rich Plasma (PRP) and Two Synovial Fluid Withdrawals","EXPERIMENTAL","Subjects randomized to ARM 2 will have 2 synovial fluid withdrawals one at the preoperative visit and one at the time of surgery. Platelet-Rich Plasma (PRP) preparation and injection will happen at the preoperative clinic visit.",[13,20,14],"Procedure: Platelet-Rich Plasma (PRP) preparation and injection",{"label":22,"type":6,"description":23,"interventionNames":24},"3mL Synovial Fluid Withdrawal and Synovial Fluid Withdrawal at the Time of Surgery","Subjects randomized to Arm 3 will have 3mL withdrawal of synovial fluid at the preoperative visit and 1 synovial fluid withdrawal at the time of surgery",[14,25],"Procedure: 3mL synovial fluid withdrawn at the preoperative visit",[27,33,38,42],{"type":28,"name":29,"description":29,"armGroupLabels":30,"otherNames":31},"PROCEDURE","Synovial Fluid withdrawal at the preoperative clinic visit",[16,9],[32],"arthrocentesis",{"type":28,"name":34,"description":34,"armGroupLabels":35,"otherNames":36},"Platelet-Rich Plasma (PRP) preparation and injection",[16],[37],"platelet rich plasma",{"type":28,"name":39,"description":39,"armGroupLabels":40,"otherNames":41},"Synovial fluid withdrawal at the time of surgery",[22,16,9],null,{"type":28,"name":43,"description":43,"armGroupLabels":44,"otherNames":41},"3mL synovial fluid withdrawn at the preoperative visit",[22],[46],{"name":47,"affiliation":48,"role":49},"Adam Yanke, MD, PhD","Associate Professor and Surgeon","PRINCIPAL_INVESTIGATOR",[51,55],{"name":47,"role":52,"phone":53,"phoneExt":41,"email":54},"CONTACT","(312) 432-2818","cartilage.restoration@rushortho.com",{"name":56,"role":52,"phone":41,"phoneExt":41,"email":57},"Jorge Chahla, MD, PhD","jorge.chahla@rushortho.com",[59],{"facility":5,"status":41,"city":60,"state":61,"zip":62,"country":63,"countryCode":64,"cosmosGeoPoint":65,"geoPoint":70,"contacts":41},"Chicago","Illinois","60612","United States","US",{"type":66,"coordinates":67},"Point",[68,69],-87.65005,41.85003,{"lat":69,"lon":68},{"type":72,"investigatorFullName":41,"investigatorTitle":41,"investigatorAffiliation":41,"oldNameTitle":41,"oldOrganization":41},"SPONSOR",[74],{"name":75,"class":6},"Arthroscopy Association of North America","100603888",false,"NCT07142369","Synovial Fluid Withdrawal or PRP Injection For Acute ACL Tears and Cytokines","Does Arthrocentesis and PRP For Acute ACL Tears With Hemarthrosis Decrease Inflammatory Cytokines At Time Of Surgery: A Prospective Randomized Control Trial (RCT)","Inclusion Criteria:\n\n* Age 18 - 50\n* English-speaking\n* Clinical evidence of ACL rupture with swelling\n* Participant must be undergoing ACL reconstruction surgery\n\nExclusion Criteria:\n\n* Age \\\u003C18 or \\>50\n* Presentation \\>3 weeks after initial injury\n* Previous traumatic ipsilateral (same side) knee injury consistent with chronic ACL tear or prior ACL surgery\n* \\> Kellgren-Lawrence grade 2 changes on preoperative x-ray\n* History of hemophilia or inflammatory arthropathy (e.g., rheumatoid arthritis)","ALL","18 Years","50 Years",{"count":86,"type":87},99,"ESTIMATED","INTERVENTIONAL",[90],"NA","The purpose of this study is to determine what effects the withdrawal of excess knee joint fluid or the injection of a factor from the blood has on swelling after a sudden anterior cruciate ligament (ACL) rupture of the knee.",[93,94],"Posttraumatic Osteoarthritis","Anterior Cruciate Ligament (ACL) Rupture",[96],"osteoarthritis","NOT_YET_RECRUITING","2026-06-17",{"date":100,"type":101},"2026-06-18","ACTUAL",{"date":103,"type":87},"2026-09",{"date":105,"type":87},"2028-12",{"name":5,"class":6},1]