T1G3R-1 Trial: Detectability and Prognostic Value of ctDNA in T1 G3 Bladder Cancer
ConditionBladder Cancer
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity Hospital, Basel, Switzerland
About this trial
T1G3 bladder cancer is a heterogeneous disease with a high risk of disease persistence after the first TUR-B, understaging, disease progression, bladder removal, and mortality.
Current risk stratification is insufficient and needs improvement. Ct-DNA could identify patients with disease persistence, progression and could monitor and tailor therapy. It might improve patient risk stratification, avoiding under- and overtreatment, reducing morbidity and mortality.
Primary objective is to investigate the detectability of ct-DNA in T1G3 urothelial bladder cancer patients and build a biobank through collection of different sample types (urine, plasma) in T1G3 bladder cancer patients which allows future retrospective testing.
Eligibility criteria
Qualifiers
patients > 18 years of age, able to give informed consent as documented by signature,
patients with a cystoscopically proven bladder cancer, suspicious for T1 stage, who will undergo TUR-B
Disqualifiers
Patients with metastases or concomitant upper tract tumor at diagnosis will
Patients with non T1 G3 cancers
Patients with upstaging, either at re-TUR-B or after immediate radical cystectomy
Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc.
Trial design
Treatments tested in this trial
- Not listed
Trial groups
No trial groups listed
Sponsors and collaborators
Source ClinicalTrials.gov