[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100521708":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":21,"centralContacts":25,"locations":31,"responsibleParty":45,"collaborators":47,"id":53,"slug":10,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":54,"sex":60,"minAge":61,"maxAge":10,"enrollmentInfo":62,"targetDuration":10,"studyType":65,"phases":10,"briefSummary":66,"conditions":67,"keywords":68,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"Tan Tock Seng Hospital","OTHER",[8,12,15,18],{"label":9,"type":10,"description":11,"interventionNames":10},"Stroke",null,"Both acutely admitted stroke patients undergoing rehabilitation and chronic recovered stroke outpatients will be recruited.",{"label":13,"type":10,"description":14,"interventionNames":10},"Traumatic Brain Injury","Both acutely admitted TBI patients undergoing rehabilitation and chronic recovered TBI outpatients will be recruited.",{"label":16,"type":10,"description":17,"interventionNames":10},"Breast Cancer","Only recovered breast cancer patients.",{"label":19,"type":10,"description":20,"interventionNames":10},"Knee Osteoarthritis","For patients with chronic knee osteoarthritis.",[22],{"name":23,"affiliation":5,"role":24},"Karen Chua","PRINCIPAL_INVESTIGATOR",[26],{"name":27,"role":28,"phone":29,"phoneExt":10,"email":30},"Low Ai Mei Jaclyn","CONTACT","68894580","Jaclyn_AM_LOW@ttsh.com.sg",[32],{"facility":5,"status":33,"city":34,"state":34,"zip":35,"country":34,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"RECRUITING","Singapore","308433","SG",{"type":38,"coordinates":39},"Point",[40,41],103.85007,1.28967,{"lat":41,"lon":40},[44],{"name":27,"role":28,"phone":10,"phoneExt":10,"email":30},{"type":46,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[48,51],{"name":49,"class":50},"Rehabilitation Research Institute of Singapore (RRIS)","UNKNOWN",{"name":52,"class":50},"Woodlands Health (WH)","100521708",false,"NCT06073106","Targeting Osteosarcopaenia and Multimorbidity for Frailty Prevention","Targeting Osteosarcopaenia and Multimorbidity for Frailty Prevention Through Identification and Deep Phenotyping Methods in Healthy Aging and High-burden Disease Cohorts.","OPTIMA-C","Inclusion Criteria:\n\n1. Age ≥ 50y\n2. Asian ethnicity\n3. First diagnosis (stroke, Traumatic Brain Injury (TBI), knee osteoarthritis, breast cancer)\n4. Living in community\n5. Able to understand 1 step simple commands\n6. For inpatients: (i) within 12 weeks of disease (stroke\u002FTBI) onset, and (ii) within 2 weeks of rehabilitation ward admission\n7. For outpatients: (i) \\>6 months from initial diagnosis of first stroke, TBI, knee osteoarthritis or breast cancer, and (ii) at least standby assistance, modified independent or independent in ambulation with \u002Fwithout walking.\n\nExclusion Criteria:\n\n1. Nursing home or dormitory resident\n2. Non-resident status in Singapore (e.g. foreign worker, tourist, temporary visit pass)\n3. Impairments affecting understanding of questionnaires and tasks: e.g. severe deafness, severe visual impairment and severe \u002Fglobal aphasia,\n4. Presence of active fractures, dislocations, non-weight bearing status, burns, unhealed wounds, active skin infections\u002Feczema and agitated behaviour or delirium\n5. Anticipated life expectancy \\\u003C 1 year\n6. Presence of tracheostomy, ventilator, renal dialysis, end-organ failure\n7. Patients with disorders of consciousness.\n8. Pregnant or lactating participants\n\n   For Knee Osteoarthritis patients only:\n9. Alternative diagnosis to knee OA e.g. Referred pain from hip or spine.\n10. Other forms of knee arthritis eg. Inflammatory, post traumatic\n11. Previous knee arthroplasty","ALL","50 Years",{"count":63,"type":64},500,"ESTIMATED","OBSERVATIONAL","The aging population and its accompanying burden from non-communicable chronic diseases predicts an increasing impact imposed by frailty on healthcare systems. This is due to a lack of normative data for older adults and reliable risk stratification methods to develop effective approaches to the prevention of frailty.\n\nIn this study, the investigators plan to form a common dataset for phenotype identification, risk stratification of frailty and its targeted treatment plans in the at-risk and mildly frail population.",[9,13,19,16],[69,70,71],"Frailty","Multimorbidity","Osteosarcopaenia","2025-04-08",{"date":74,"type":75},"2025-04-11","ACTUAL",{"date":77,"type":75},"2025-01-01",{"date":79,"type":64},"2027-01",{"name":5,"class":6},1]