TB Type and Spirometry Result vs. Functional Capacity Based on 6MWT in People With Post-TB Lung Disease
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age10-18
SponsorUniversitas Padjadjaran
About this trial
Post-Tuberculosis Lung Disease (PTLD) is defined as chronic respiratory impairment due to previous pulmonary TB. Children recovering from pulmonary TB undergo ongoing respiratory health challenges, including more frequent respiratory symptoms, reduced lung volumes, and a threefold higher rate of pulmonary dysfunction compared to healthy children. These conditions could lead to long-term health consequences such as difficulties in performing daily activities. Pulmonary function impairment in PTLD includes approximately 10% of patients losing more than 50% of lung function. Adolescents who have undergone TB treatment often experience pulmonary function impairment and reduced physical capacity. This aims of this study is to analyze the correlation between type of tuberculosis, spirometry result, and functional capacity in adolescents with post-tuberculosis lung disease.
This study is an analytical observational study with a cross-sectional approach. This study is conducted at Department of Physical Medicine and Rehabilitation, Hasan Sadikin Hospital, Bandung, starting in March until May 2026. Inclusion criteria including: adolescents (10-18 year old), and diagnosed with post tuberculosis lung disease by pediatrician, and capable of performing the 6MWT. The participants with post TB lung disease will undergo spirometry and functional capacity assessment using the 6-minute walk test (6MWT). Outcomes include spirometry result and functional capacity using 6MWT.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Adolescents (10-18 year old)
Diagnosed with post tuberculosis lung disease by pediatrician
Capable of performing the 6MWT
Disqualifiers
Diagnosed with another lung disease
Having physical limitations that hinder the 6MWT
Trial population
Post tuberculosis patient who come to Department of Physical Medicine and Rehabilitation, Hasan Sadikin Hospital, Bandung
Trial design
Design model
Other
Time perspective
Cross-sectional
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
Change in 6-Minute Walk Distance (6MWD) measured in METs
Functional capacity will be assessed using the standardized 6-Minute Walk Test (6MWT), conducted according to American Thoracic Society guidelines. Participants will be instructed to walk back and forth along a marked corridor for six minutes, and the total distance covered will be recorded in meters. In addition, metabolic equivalents (METs) will be estimated from walking speed using the ACSM walking equation: VO₂ (ml/kg/min) = 3.5 + 0.1 × speed (m/min), with METs calculated as VO₂/3.5. Both outcomes-distance in meters and estimated METs-will be reported as mean change from baseline at the specified time points.
Time frame
12 weeks2
Forced Expiratory Volume in 1 second (FEV1) in liter
Spirometry will be performed according to American Thoracic Society/European Respiratory Society (ATS/ERS) guidelines. Participants will perform a forced vital capacity (FVC) maneuver consisting of full inspiration to total lung capacity, followed by a rapid, forceful, and sustained expiration into the mouthpiece for at least 6 seconds (or until a volume plateau is achieved). A subsequent rapid inspiration will be performed to complete the flow-volume loop when required. A minimum of three acceptable maneuvers will be obtained for each participant to ensure reproducibility. From these maneuvers, Forced Expiratory Volume in 1 second (FEV1) will be recorded in liters at each assessment time point and summarized as mean and standard deviation across participants.
Time frame
12 weeks3
Forced Vital Capacity (FVC) in liters
Spirometry will be performed according to American Thoracic Society/European Respiratory Society (ATS/ERS) guidelines. Participants will perform a forced vital capacity (FVC) maneuver consisting of full inspiration to total lung capacity, followed by a rapid, forceful, and sustained expiration into the mouthpiece for at least 6 seconds (or until a volume plateau is achieved). A subsequent rapid inspiration will be performed to complete the flow-volume loop when required. A minimum of three acceptable maneuvers will be obtained for each participant to ensure reproducibility. From these maneuvers, Forced Vital Capacity (FVC) will be recorded in liters at each assessment time point and summarized as mean and standard deviation across participants.
Time frame
12 weeksSponsors and contacts
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Source ClinicalTrials.gov