[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100053888":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":30,"centralContacts":34,"locations":40,"responsibleParty":59,"collaborators":61,"id":63,"slug":12,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":70,"sex":71,"minAge":12,"maxAge":12,"enrollmentInfo":72,"targetDuration":12,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":84,"whyStopped":12,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Children's Hospital Medical Center, Cincinnati","OTHER",[8,13,16,22],{"label":9,"type":10,"description":11,"interventionNames":12},"Inspiration\u002FDiscovery (1A)","NO_INTERVENTION","Semi-structured qualitative interviews with screen-positive community members (or parents\u002Fguardians of community members) and ADUNU providers to characterize multilevel barriers and facilitators.",null,{"label":14,"type":10,"description":15,"interventionNames":12},"Ideation\u002FDesign (1B)","A structured participatory design workshop with a 15-member HCD expert panel, followed by iterative co-design sessions to produce finalized ACT+ features and workflows.",{"label":17,"type":18,"description":19,"interventionNames":20},"Healthcare Facilities will receive ACT+ Intervention","ACTIVE_COMPARATOR","The ACT+ strategy consists of three coordinated, registry-enabled implementation components co-designed and refined through the Aim 1 HCD process.\n\nComponent 1: Digitized Pre-Confirmation Registry Entry and Patient Tracking ACT+ will enable entry of screen-positive individuals into the ACT registry at the time of positive screen (prior to confirmatory diagnosis).\n\nComponent 2: Patient Tracing and Reminder System ACT+ will support automated and semi-automated outreach to screen-positive who have not yet completed confirmatory echocardiography.\n\nComponent 3: Audit and Feedback for Providers and Facilities ACT+ dashboards will provide facility-level, real-time feedback on LTFU rates, confirmation completion, and the screening-to-SAP initiation cascade.",[21],"Other: The ACT+ Strategy",{"label":23,"type":10,"description":24,"interventionNames":12},"Control: Standard of Care","Facilities in the control arm will continue current standard ADUNU practice: screen-positive individuals receive verbal and written referral information to one of three confirmatory sites immediately following screening.",[26],{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":12},"The ACT+ Strategy","The Active Community Case Management Tool (ACT) is a cloud-based, dynamic RHD case management tool developed by CCHMC in partnership with global stakeholders, including UHI and the RRCU. ACT provides real-time data on patient status, clinical outcomes, and care processes, supporting both individual patient management (electronic medical record functions) and system-level quality improvement (registry and dashboard functions).",[17],[31],{"name":32,"affiliation":5,"role":33},"Andrea Beaton","PRINCIPAL_INVESTIGATOR",[35],{"name":36,"role":37,"phone":38,"phoneExt":12,"email":39},"Isabella Brigham","CONTACT","513-517-1307","isabella.aspromonte@cchmc.org",[41],{"facility":42,"status":12,"city":43,"state":12,"zip":12,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Uganda Heart Institute","Kampala","Uganda","UG",{"type":47,"coordinates":48},"Point",[49,50],32.58219,0.31628,{"lat":50,"lon":49},[53,57],{"name":54,"role":37,"phone":55,"phoneExt":12,"email":56},"Jafes Pulle","0784936334","jpulle@rrcuganda.org",{"name":58,"role":33,"phone":12,"phoneExt":12,"email":12},"Jafes Pulles",{"type":60,"investigatorFullName":12,"investigatorTitle":12,"investigatorAffiliation":12,"oldNameTitle":12,"oldOrganization":12},"SPONSOR",[62],{"name":42,"class":6},"100053888",false,"NCT07606131","Testing a Registry-Based Strategy (ACT+) to Reduce Loss to Follow-Up in Rheumatic Heart Disease Screening in Uganda","Developing and Testing a Registry-Enabled Strategy (ACT+) to Reduce Loss to Follow-Up Between Screening and Confirmation of Rheumatic Heart Disease in Uganda","SHIELD 2","Inclusion Criteria: Community Members\n\n* 18 years of age or older\n* Received a positive ADUNU echocardiographic screening result within the past 24 months OR parent\u002Flegal guardian of a minor who received a positive ADUNU echocardiographic screening result within the past 24 months\n\nInclusion Criteria: Providers\n\n* Employed at an ADUNU-participating facility or confirmatory echo facilities at the time of study\n* Holds a designated ADUNU role (nurse screener, confirmatory provider, or referral support staff) or is involved in RHD screening, diagnosis or care\n* Ability to provide informed consent in Acholi, Luo, or English\n\nInclusion Criteria: Regional RHT ACT Nurse Coordinator\n\n* Employed as a Regional ACT Nurse at the time of study\n* Has familiarity with ADUNU program\n* Ability to provide informed consent in Acholi, Luo, or English\n\nInclusion Criteria: District Health Office Team Members and District RHD Focal Persons\n\n* Employed at District Health Office within an ADUNU-participating district\n* Has familiarity with ADUNU program\n* Ability to provide informed consent in Acholi, Luo, or English\n\nExclusion Criteria:\n\n* No formal exclusion criteria beyond inability to provide informed consent. Individuals with significant cognitive or communication impairment precluding interview participation will not be enrolled.",true,"ALL",{"count":73,"type":74},16,"ESTIMATED","INTERVENTIONAL",[77],"NA","This study aims to improve follow-up care after positive rheumatic heart disease (RHD) screening in Northern Uganda. It will identify barriers and co-develop an enhanced ACT+ strategy, then evaluate its effectiveness in increasing linkage to confirmatory echocardiography, along with its adoption, acceptability, and feasibility. Secondary outcomes include time to diagnosis, initiation of treatment, and factors influencing implementation.",[80],"Rheumatic Heart Disease",[82,83],"Rheumatic heart disease","SHIELD","NOT_YET_RECRUITING","2026-07-10",{"date":87,"type":88},"2026-07-13","ACTUAL",{"date":90,"type":74},"2026-08-01",{"date":92,"type":74},"2028-06-01",{"name":5,"class":6},1]