Investigators combined the clinical and radiomics characteristics of resectable non-small cell lung cancer patients to construct an accurate model for preoperative prediction of mediastinal lymph node status. For the patients in the experimental group, lymph nodes will be dissected based on the predicted lymph node status by the model, while in the control group, the lymph nodes will be dissected according to the NCCN guidelines (2023). Investigators expect that performing lymph node dissection according to the predictive model can lead to better prognosis for patients.
Age range from 18 to 70 years old;
Chest CT shows a single pulmonary nodule, which may be adenocarcinoma or squamous cell carcinoma;
Chest CT shows multiple pulmonary nodules, but preoperative evaluation suggests that pulmonary nodules other than the main lesion are benign;
Preoperative auxiliary examination evaluates the patient as clinically resectable lung adenocarcinoma or squamous cell carcinoma in stages I, II, or IIIA (UICC-TNM 9th edition);
Chest CT suggests multiple primary lung cancer or metastatic cancer;
Previous history of thoracic surgery;
Previous history of malignant tumors;
History of neoadjuvant therapy;
Parallel
Lymph node dissection based on the guidelines
Procedure/SurgeryDuring surgery, mediastinal lymph nodes will be dissected based on the NCCN guidelines (2023) .
Lymph node dissection based on the model
Procedure/SurgeryDuring surgery, lymph nodes will be dissected based on the predicted lymph node status by the model.
Consistency rate between preoperative prediction results and postoperative pathological results
Compare postoperative lymph node pathology results with preoperative prediction results
Postoperative complications
Observation of complications within 30 days after surgery
Postoperative recurrence rate
Observe for recurrence within 2 years after surgery
Disease-free survival
Follow up after surgery to determine if there is any recurrence or metastasis, and calculate disease-free survival
Overall survival
Follow up after surgery to determine if there is death, and calculate overall survival
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