The Effects of Cold-water Immersion on Exercise Performance Recovery and Postprandial Plasma Aminoacidemia

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-40
SponsorMcGill University

About this trial

In order to optimize sports performance, high-level athletes are required to manage conflicting training objectives, which often result in periods of high-volume training. These athletes need to perform heavy resistance training sessions to promote physiological adaptations, which consequently induce fatigue. Yet, they need to minimize fatigue to perform subsequent high-quality training sessions often within the same day. To support these training endeavours, a high-quality dietary regimen and adequate protein consumption is deemed to be an essential component of an athlete's recovery plan, as it has been shown to support muscle recovery and reduce muscle inflammation following exercise. Indeed, current sports nutrition recommendations advocate for the consumption of dietary protein and carbohydrate after exercise to promote tissue repair and replenish muscle energy stores (glycogen). Additionally, previous research has shown how water immersion therapies post-exercise may alleviate fatigue and restore performance. However, little is known about how different temperatures, as well as timing of cold-water immersion can support performance recovery in a population of athletes adhering to contemporary post-exercise nutrition recommendations. The objective of this project is to investigate the effects of timing of cold-water immersion relative to exercise on performance recovery within the same day, as well as to investigate whether cold water immersion augments blood amino acid concentrations after exercise and protein intake.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Healthy adult between 18 - 40 years (inclusive).

Individual with a BMI between >18.5 and <30 kg/m2 (inclusive).

Individual who is in good general health (no uncontrolled diseases or conditions).

individual with a history of regular resistance training ≥2 per week for the past six-months.

Disqualifiers

Individual who is lactating, pregnant or planning to become pregnant during the study.

Females with irregular menstrual cycles (defined as outside 24-38 days cycle range, based on self-reports).

Individual who adheres to a diet (e.g., vegan diet) that restricts consumption of dairy products.

Has a known sensitivity, intolerability, or allergy to any of the study products or their excipients (i.e., lactose intolerant).

Trial design

Design model

Crossover

Treatments tested in this trial

  • immediate cold-water immersion

    Other intervention

    immediate 10 minute water immersion in 10 degree Celsius

  • delayed cold-water immersion

    Other intervention

    3 hour delayed 10 minute water immersion in 10 degree Celsius

  • immediate thermoneutral water immersion

    Other intervention

    immediate 10 minute water immersion in 35 degree Celsius

Treatment groups

12 Participants
are divided into 3 treatment groups
Group A: CWI_0Experimental treatment 1 intervention
Group B: CWI_3Experimental treatment 1 intervention
Group C: THERMActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Prolonged maximum voluntary isometric contraction of the knee extensors peak force

The participant will be asked to perform one five-second maximum voluntary isometric contraction of the knee extensors on an isometric dynamometer at a 60° angle of the knee joint. The force-time profile will be used to derive the peak force (Newton)

Time frame
120 minutes prior to water immersion, immediately prior to water immersion, 300 minutes post protein intake.

Secondary outcomes

1

postprandial plasma total amino acid concentration incremental area-under-the-curve

Free leucine, isoleucine, valine, histidine, lysine, methionine, phenylalanine, threonine, tryptophan, arginine, glutamine, glycine, alanine, serine, glutamic acid, aspartic acid, asparagine, tyrosine, cysteine, proline (combined) at 11 timepoints (time = -120, 0, 15, 30, 45, 60, 90, 120, 180, 240, 300 minutes) umol/L

Time frame
-120, 0, 15, 30, 45, 60, 90, 120, 180, 240, 300 minutes in the post-prandial period
2

postprandial plasma branched chain amino acid concentration incremental area-under-the-curve

Free leucine, isoleucine, valine (combined) at 11 timepoints (time = -120, 0, 15, 30, 45, 60, 90, 120, 180, 240, 300 minutes) umol/L

Time frame
-120, 0, 15, 30, 45, 60, 90, 120, 180, 240, 300 minutes in the post-prandial period
3

postprandial plasma essential amino acid concentration incremental area-under-the-curve

Free leucine, isoleucine, valine, histidine, lysine, methionine, phenylalanine, threonine, tryptophan (combined) at 11 timepoints (time = -120, 0, 15, 30, 45, 60, 90, 120, 180, 240, 300 minutes) umol/L

Time frame
-120, 0, 15, 30, 45, 60, 90, 120, 180, 240, 300 minutes in the post-prandial period
4

postprandial plasma leucine concentration incremental area-under-the-curve

leucine at 11 timepoints (time = -120, 0, 15, 30, 45, 60, 90, 120, 180, 240, 300 minutes) umol/L

Time frame
-120, 0, 15, 30, 45, 60, 90, 120, 180, 240, 300 minutes in the post-prandial period

Other outcomes

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